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Thyroid gland atypical follicular adenoma

MedGen UID:
224756
•Concept ID:
C1266046
•
Neoplastic Process
Synonym: Atypical follicular adenoma
SNOMED CT: Atypical follicular adenoma (128892009)
 
Monarch Initiative: MONDO:0004524

Definition

An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with well-developed or partially developed nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. Tumors in which vascular invasion has been excluded by all means are called non-invasive follicular thyroid neoplasms with papillary-like nuclear features. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland atypical follicular adenoma

Professional guidelines

PubMed

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.
Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383
Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy.
Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S
Ann Surg Oncol 2013 Jan;20(1):60-5. Epub 2012 Sep 1 doi: 10.1245/s10434-012-2601-2. PMID: 22941160Free PMC Article
Challenging lesions in the differential diagnosis of endocrine tumors: parathyroid carcinoma.
Delellis RA
Endocr Pathol 2008 Winter;19(4):221-5. doi: 10.1007/s12022-008-9050-2. PMID: 19058032

Recent clinical studies

Etiology

Thyroid transcription factor-1 expression in lung neuroendocrine tumours: a gender-related biomarker?
La Salvia A, Siciliani A, Rinzivillo M, Verrico M, Baldelli R, Puliani G, Modica R, Zanata I, Persano I, Fanciulli G, Bassi M, Mancini M, Bellino S, Giannetta E, Ibrahim M, Panzuto F, Brizzi MP, Faggiano A
Endocrine 2024 Feb;83(2):519-526. Epub 2023 Sep 30 doi: 10.1007/s12020-023-03542-0. PMID: 37775725Free PMC Article
Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.
Bentestuen M, Gossili F, Almasi CE, Zacho HD
Cancer Imaging 2022 Sep 3;22(1):44. doi: 10.1186/s40644-022-00484-0. PMID: 36057635Free PMC Article
Overview of the 2017 WHO Classification of Pituitary Tumors.
Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057
Is there an association between thyroid function abnormalities and breast cancer?
Angelousi A, Diamanti-Kandarakis E, Zapanti E, Nonni A, Ktenas E, Mantzou A, Kontzoglou K, Kouraklis G
Arch Endocrinol Metab 2017 Jan-Feb;61(1):54-61. Epub 2016 Aug 25 doi: 10.1590/2359-3997000000191. PMID: 28273204Free PMC Article
Reducing indeterminate thyroid FNAs.
Renshaw AA, Gould EW
Cancer Cytopathol 2015 Apr;123(4):237-43. Epub 2015 Jan 20 doi: 10.1002/cncy.21520. PMID: 25644425

Diagnosis

Interobserver variability in cytopathology: How much do we agree?
Acanfora G, Carillo AM, Dello Iacovo F, Salatiello M, Pisapia P, Bellevicine C, Troncone G, Vigliar E
Cytopathology 2024 Jul;35(4):444-453. Epub 2024 Mar 27 doi: 10.1111/cyt.13378. PMID: 38534091
Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
Gerlach L, Beyer AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A
Sci Rep 2023 Nov 3;13(1):18993. doi: 10.1038/s41598-023-46395-3. PMID: 37923782Free PMC Article
C Cell and Follicular Epithelial Cell Precursor Lesions of the Thyroid.
Scognamiglio T
Arch Pathol Lab Med 2017 Dec;141(12):1646-1652. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0399-RA. PMID: 28644684
Thyrotoxicosis.
Kannan CR, Seshadri KG
Dis Mon 1997 Sep;43(9):601-77. PMID: 9301645
Neurofibromatosis update.
Riccardi VM
Neurofibromatosis 1989;2(5-6):284-91. PMID: 2518510

Therapy

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.
Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383
Infiltration of the thyroid gland by T-cell prolymphocytic leukemia.
Fujiwara K, Fukuhara T, Kitano H, Okazaki T
Thyroid 2014 Aug;24(8):1314-8. Epub 2014 Jun 18 doi: 10.1089/thy.2013.0462. PMID: 24762052
Primary thyroid lymphoma associated with Graves' disease.
Doi Y, Goto A, Murakami T, Yamashita H, Yamashita H, Noguchi S
Thyroid 2004 Sep;14(9):772-6. doi: 10.1089/thy.2004.14.772. PMID: 15361265
Meningioma metastatic to thyroid gland.
Hasan R, Marshall MC Jr, Medhi M, Arshad A, Braun A, Panageas E
Endocr Pract 2001 Sep-Oct;7(5):370-4. doi: 10.4158/EP.7.5.370. PMID: 11585373
Histologic changes in Graves' thyroid gland after 131I therapy for hyperthyroidism.
Mizukami Y, Michigishi T, Nonomura A, Hashimoto T, Noguchi M, Ohmura K, Matsubara F
Acta Pathol Jpn 1992 Jun;42(6):419-26. doi: 10.1111/j.1440-1827.1992.tb03247.x. PMID: 1502902

Prognosis

Thyroid transcription factor-1 expression in lung neuroendocrine tumours: a gender-related biomarker?
La Salvia A, Siciliani A, Rinzivillo M, Verrico M, Baldelli R, Puliani G, Modica R, Zanata I, Persano I, Fanciulli G, Bassi M, Mancini M, Bellino S, Giannetta E, Ibrahim M, Panzuto F, Brizzi MP, Faggiano A
Endocrine 2024 Feb;83(2):519-526. Epub 2023 Sep 30 doi: 10.1007/s12020-023-03542-0. PMID: 37775725Free PMC Article
Synchronous mucoepidermoid carcinoma and papillary microcarcinomas of the thyroid gland.
Gupta KK, Garas G, Wilkes J, De M
BMJ Case Rep 2022 Nov 22;15(11) doi: 10.1136/bcr-2022-252117. PMID: 36414338Free PMC Article
Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.
Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383
Is there an association between thyroid function abnormalities and breast cancer?
Angelousi A, Diamanti-Kandarakis E, Zapanti E, Nonni A, Ktenas E, Mantzou A, Kontzoglou K, Kouraklis G
Arch Endocrinol Metab 2017 Jan-Feb;61(1):54-61. Epub 2016 Aug 25 doi: 10.1590/2359-3997000000191. PMID: 28273204Free PMC Article
Reducing indeterminate thyroid FNAs.
Renshaw AA, Gould EW
Cancer Cytopathol 2015 Apr;123(4):237-43. Epub 2015 Jan 20 doi: 10.1002/cncy.21520. PMID: 25644425

Clinical prediction guides

Interobserver variability in cytopathology: How much do we agree?
Acanfora G, Carillo AM, Dello Iacovo F, Salatiello M, Pisapia P, Bellevicine C, Troncone G, Vigliar E
Cytopathology 2024 Jul;35(4):444-453. Epub 2024 Mar 27 doi: 10.1111/cyt.13378. PMID: 38534091
Pitfalls in Thyroid Fine-Needle Aspiration Cytopathology: An Approach to Atypical Findings.
Juhlin CC, Baloch ZW
Acta Cytol 2024;68(3):179-193. Epub 2023 Dec 20 doi: 10.1159/000535907. PMID: 38118428
Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
Gerlach L, Beyer AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A
Sci Rep 2023 Nov 3;13(1):18993. doi: 10.1038/s41598-023-46395-3. PMID: 37923782Free PMC Article
Assessment of The Bethesda System for Reporting Thyroid Cytopathology.
Sauter JL, Lehrke H, Zhang X, Al Badri OT, Rodriguez-Gutierrez R, Delivanis DA, Singh Ospina N, Donegan D, Hamidi O, Iñiguez-Ariza N, Sharma A, Kittah NEN, Tamhane SU, Hurtado Andrade MD, Kotwal A, Jenkins SM, Spears G, Rivera M, Dean DS, Henry MR
Am J Clin Pathol 2019 Sep 9;152(4):502-511. doi: 10.1093/ajcp/aqz076. PMID: 31305880Free PMC Article
Atypical follicular cells with equivocal features of papillary thyroid carcinoma is not a low-risk cytologic diagnosis.
Luu MH, Fischer AH, Stockl TJ, Pisharodi L, Owens CL
Acta Cytol 2011;55(6):526-30. Epub 2011 Dec 9 doi: 10.1159/000333227. PMID: 22156461

Recent systematic reviews

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.
Bentestuen M, Gossili F, Almasi CE, Zacho HD
Cancer Imaging 2022 Sep 3;22(1):44. doi: 10.1186/s40644-022-00484-0. PMID: 36057635Free PMC Article

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