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Persistent infection

MedGen UID:
688822
•Concept ID:
C1264606
•
Disease or Syndrome
Synonyms: Infection, Long Term; Infection, Persistent; Long Term Infection; Long Term Infections; Persistent Infection; Persistent Infections
SNOMED CT: Persistent infection (115648009)

Definition

Infection which lasts for a long period with continuous display of clinical features. Persistent infection arises due to inability of host cells to clear primary infections completely. When persistent infections are cleared so that infection symptoms are under control they are often referred to as chronic infections. LATENT INFECTIONS are infections in which manifestation of clinical symptoms appear later. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPersistent infection

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on hepatitis delta virus.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):433-460. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.05.001. PMID: 37364791
Failure of Regenerative Endodontic Procedures: Case Analysis and Subsequent Treatment Options.
Lee C, Song M
J Endod 2022 Sep;48(9):1137-1145. Epub 2022 Jun 14 doi: 10.1016/j.joen.2022.06.002. PMID: 35714726
Current trends in the management and prevention of human papillomavirus (HPV) infection.
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567

Recent clinical studies

Etiology

Inactivated vaccine dosage and serum IgG levels correlate with persistent COVID-19 infections in hematologic malignancy patients during the Omicron Surge in China.
Ye L, Yang Y, Zhang X, Wang L, Zhu L, Li X, Zhou Y, Zheng X, Zhou X, Ren Y, Ma L, Xu G, Yang C, Wang H, Zhou D, Yang M, Ye X, Wei J, Yu W, Qian J, Lou Y, Xie W, Huang J, Meng H, Jin J, Tong H
BMC Infect Dis 2024 Oct 11;24(1):1141. doi: 10.1186/s12879-024-10063-2. PMID: 39394593
HPV16 E6-induced M2 macrophage polarization in the cervical microenvironment via exosomal miR-204-5p.
Chen X, Liu Y, Luo X, Pan T, Zhang T, Hu L, Wu B, Liu W, Wei F
Sci Rep 2024 Oct 10;14(1):23725. doi: 10.1038/s41598-024-74399-0. PMID: 39390116Free PMC Article
Non-adherence to ivermectin in onchocerciasis-endemic communities with persistent infection in the Bono Region of Ghana: a mixed-methods study.
Otabil KB, Basáñez MG, Ankrah B, Bart-Plange EJ, Babae TN, Kudzordzi PC, Darko VA, Raji AS, Datsa L, Boakye AA, Yeboah MT, Fodjo JNS, Schallig HDFH, Colebunders R
BMC Infect Dis 2023 Nov 16;23(1):805. doi: 10.1186/s12879-023-08806-8. PMID: 37974087Free PMC Article

Diagnosis

Inactivated vaccine dosage and serum IgG levels correlate with persistent COVID-19 infections in hematologic malignancy patients during the Omicron Surge in China.
Ye L, Yang Y, Zhang X, Wang L, Zhu L, Li X, Zhou Y, Zheng X, Zhou X, Ren Y, Ma L, Xu G, Yang C, Wang H, Zhou D, Yang M, Ye X, Wei J, Yu W, Qian J, Lou Y, Xie W, Huang J, Meng H, Jin J, Tong H
BMC Infect Dis 2024 Oct 11;24(1):1141. doi: 10.1186/s12879-024-10063-2. PMID: 39394593

Therapy

Acute and chronic wound infections: microbiological, immunological, clinical and therapeutic distinctions.
Hurlow J, Bowler PG
J Wound Care 2022 May 2;31(5):436-445. doi: 10.12968/jowc.2022.31.5.436. PMID: 35579319
Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection.
Bernard L, Arvieux C, Brunschweiler B, Touchais S, Ansart S, Bru JP, Oziol E, Boeri C, Gras G, Druon J, Rosset P, Senneville E, Bentayeb H, Bouhour D, Le Moal G, Michon J, Aumaître H, Forestier E, Laffosse JM, Begué T, Chirouze C, Dauchy FA, Devaud E, Martha B, Burgot D, Boutoille D, Stindel E, Dinh A, Bemer P, Giraudeau B, Issartel B, Caille A
N Engl J Med 2021 May 27;384(21):1991-2001. doi: 10.1056/NEJMoa2020198. PMID: 34042388
Human papillomavirus vaccine against cervical cancer: Opportunity and challenge.
Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, Gao C, Ma D, Liao S
Cancer Lett 2020 Feb 28;471:88-102. Epub 2019 Dec 5 doi: 10.1016/j.canlet.2019.11.039. PMID: 31812696
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M
Cochrane Database Syst Rev 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254Free PMC Article

Prognosis

Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies.
Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Human Papillomavirus: Screening, Testing, and Prevention.
Quinlan JD
Am Fam Physician 2021 Aug 1;104(2):152-159. PMID: 34383440
Family History of Gastric Cancer and Helicobacter pylori Treatment.
Choi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, Joo J
N Engl J Med 2020 Jan 30;382(5):427-436. doi: 10.1056/NEJMoa1909666. PMID: 31995688
Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males.
Giuliano AR, Palefsky JM, Goldstone S, Moreira ED Jr, Penny ME, Aranda C, Vardas E, Moi H, Jessen H, Hillman R, Chang YH, Ferris D, Rouleau D, Bryan J, Marshall JB, Vuocolo S, Barr E, Radley D, Haupt RM, Guris D
N Engl J Med 2011 Feb 3;364(5):401-11. doi: 10.1056/NEJMoa0909537. PMID: 21288094Free PMC Article
Reactive arthritis.
Kwiatkowska B, Filipowicz-Sosnowska A
Pol Arch Med Wewn 2009 Jan-Feb;119(1-2):60-5. PMID: 19341180

Clinical prediction guides

Zeb2 drives the formation of CD11c(+) atypical B cells to sustain germinal centers that control persistent infection.
Gao X, Shen Q, Roco JA, Dalton B, Frith K, Munier CML, Ballard FD, Wang K, Kelly HG, Nekrasov M, He JS, Jaeger R, Carreira P, Ellyard JI, Beattie L, Enders A, Cook MC, Zaunders JJ, Cockburn IA
Sci Immunol 2024 Mar 29;9(93):eadj4748. doi: 10.1126/sciimmunol.adj4748. PMID: 38330097
Epidemiology of Hepatitis E.
Geng Y, Shi T, Wang Y
Adv Exp Med Biol 2023;1417:33-48. doi: 10.1007/978-981-99-1304-6_3. PMID: 37223857
Current trends in the management and prevention of human papillomavirus (HPV) infection.
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Viral-bacterial interactions in the respiratory tract.
Bellinghausen C, Rohde GGU, Savelkoul PHM, Wouters EFM, Stassen FRM
J Gen Virol 2016 Dec;97(12):3089-3102. Epub 2016 Oct 18 doi: 10.1099/jgv.0.000627. PMID: 27902340
Epidemiology of Hepatitis E.
Geng Y, Wang Y
Adv Exp Med Biol 2016;948:39-59. doi: 10.1007/978-94-024-0942-0_3. PMID: 27738978

Recent systematic reviews

Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis.
Main E, Rand S
Cochrane Database Syst Rev 2023 May 5;5(5):CD002011. doi: 10.1002/14651858.CD002011.pub3. PMID: 37144842Free PMC Article
The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis.
Tamarelle J, Thiébaut ACM, de Barbeyrac B, Bébéar C, Ravel J, Delarocque-Astagneau E
Clin Microbiol Infect 2019 Jan;25(1):35-47. Epub 2018 May 3 doi: 10.1016/j.cmi.2018.04.019. PMID: 29729331Free PMC Article
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors.
Arbyn M, Xu L, Simoens C, Martin-Hirsch PP
Cochrane Database Syst Rev 2018 May 9;5(5):CD009069. doi: 10.1002/14651858.CD009069.pub3. PMID: 29740819Free PMC Article
Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M
Cochrane Database Syst Rev 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254Free PMC Article

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