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Endocervical adenocarcinoma

MedGen UID:
688039
•Concept ID:
C1263762
•
Neoplastic Process
Synonyms: Adenocarcinoma of endocervix; endocervical adenocarcinoma; endocervical adenocarcinoma, usual type; endocervix adenocarcinoma
SNOMED CT: Endocervical adenocarcinoma (123842006); Adenocarcinoma of endocervix (123842006)
 
Monarch Initiative: MONDO:0000554

Definition

An adenocarcinoma that arises from the endocervix. It is the most common type of endocervical adenocarcinoma. The neoplastic epithelium shows a pseudostratified architecture and the malignant cells have enlarged, elongated, and hyperchromatic nuclei. [from MONDO]

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Ehmann S, Sassine D, Straubhar AM, Praiss AM, Aghajanian C, Alektiar KM, Broach V, Cadoo KA, Jewell EL, Boroujeni AM, Kyi C, Leitao MM, Mueller JJ, Murali R, Bhaloo SI, O'Cearbhaill RE, Park KJ, Sonoda Y, Weigelt B, Zamarin D, Abu-Rustum N, Friedman CF
Gynecol Oncol 2022 Dec;167(3):458-466. Epub 2022 Oct 15 doi: 10.1016/j.ygyno.2022.10.003. PMID: 36253302Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Diagnosis

Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Ehmann S, Sassine D, Straubhar AM, Praiss AM, Aghajanian C, Alektiar KM, Broach V, Cadoo KA, Jewell EL, Boroujeni AM, Kyi C, Leitao MM, Mueller JJ, Murali R, Bhaloo SI, O'Cearbhaill RE, Park KJ, Sonoda Y, Weigelt B, Zamarin D, Abu-Rustum N, Friedman CF
Gynecol Oncol 2022 Dec;167(3):458-466. Epub 2022 Oct 15 doi: 10.1016/j.ygyno.2022.10.003. PMID: 36253302Free PMC Article
NCCN Guidelines Insights: Cervical Cancer, Version 1.2020.
Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Huh WK, Lurain Iii JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Sisodia R, Tillmanns T, Ueda S, Urban R, Wyse E, McMillian NR, Motter AD
J Natl Compr Canc Netw 2020 Jun;18(6):660-666. doi: 10.6004/jnccn.2020.0027. PMID: 32502976
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Therapy

Recent advances in photodynamic therapy combined with chemotherapy for cervical cancer: a systematic review.
Carobeli LR, Santos ABC, Martins LBM, Damke E, Consolaro MEL
Expert Rev Anticancer Ther 2024 May;24(5):263-282. Epub 2024 Apr 2 doi: 10.1080/14737140.2024.2337259. PMID: 38549400
Targeting HER2-mutant metastatic cervical cancer with neratinib: Final results from the phase 2 SUMMIT basket trial.
Friedman CF, D'Souza A, Bello Roufai D, Tinker AV, de Miguel M, Gambardella V, Goldman J, Loi S, Melisko ME, Oaknin A, Spanggaard I, Shapiro GI, ElNaggar AC, Panni S, Ravichandran V, Frazier AL, DiPrimeo D, Eli LD, Solit DB
Gynecol Oncol 2024 Feb;181:162-169. Epub 2024 Jan 11 doi: 10.1016/j.ygyno.2023.12.004. PMID: 38211393Free PMC Article
Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets.
Friedman CF, Ravichandran V, Miller K, Vanderbilt C, Zhou Q, Iasonos A, Vivek M, Mishra P, Leitao MM Jr, Broach V, Sonoda Y, Kyi C, Zamarin D, O'Cearbhaill RE, Konner J, Berger MF, Weigelt B, Momeni Boroujeni A, Park KJ, Aghajanian C, Solit DB, Donoghue MTA
Clin Cancer Res 2023 Nov 14;29(22):4660-4668. doi: 10.1158/1078-0432.CCR-23-1078. PMID: 37643132Free PMC Article
Endocervical adenocarcinoma implantation in episiotomy scar: a case report and  review of the literature.
Yarandi F, Aghili M, Ramhormozian S, Shirali E
J Med Case Rep 2023 Mar 8;17(1):100. doi: 10.1186/s13256-023-03786-4. PMID: 36882845Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Prognosis

Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer.
Wang Y, Wang C, Qiu J, Qu X, Peng J, Lu C, Zhang M, Zhang M, Qi X, Li G, Hua K
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003667. PMID: 35288463Free PMC Article
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.
Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527
Recent advances in invasive adenocarcinoma of the cervix.
Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Clinical prediction guides

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Clinicopathological features and immunophenotype of Silva pattern system in endocervical adenocarcinoma.
Zeng C, Wu JK, Lu X
Int J Exp Pathol 2023 Jun;104(3):140-150. Epub 2023 Mar 16 doi: 10.1111/iep.12470. PMID: 36928883Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.
Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent systematic reviews

Association between Silva pattern-based classification and endocervical adenocarcinoma: a systematic review and meta-analysis.
Chen M, Han L, Wang Y, Chen Y, Zheng A
Int J Gynecol Cancer 2024 Nov 4;34(11):1704-1710. doi: 10.1136/ijgc-2024-005639. PMID: 39277184
The impacts of dipeptidyl- peptidase 4 (DPP-4) inhibitors on common female malignancies: A systematic review.
Niazmand A, Nedaeinia R, Vatandoost N, Jafarpour S, Safabakhsh S, Kolahdouz M, Ferns GA, Salehi R
Gene 2024 Nov 15;927:148659. Epub 2024 Jun 10 doi: 10.1016/j.gene.2024.148659. PMID: 38866262
Recent advances in photodynamic therapy combined with chemotherapy for cervical cancer: a systematic review.
Carobeli LR, Santos ABC, Martins LBM, Damke E, Consolaro MEL
Expert Rev Anticancer Ther 2024 May;24(5):263-282. Epub 2024 Apr 2 doi: 10.1080/14737140.2024.2337259. PMID: 38549400
Diagnostic accuracy of HIK1083 and MUC6 as immunohistochemical markers of endocervical gastric-type adenocarcinoma: A systematic review and meta-analysis.
Fulgione C, Raffone A, Travaglino A, Arciuolo D, Santoro A, Cianfrini F, Russo D, Varricchio S, Raimondo I, Inzani F, Mollo A, Guida M, Mascolo M, Zannoni GF
Pathol Res Pract 2023 Jan;241:154261. Epub 2022 Dec 5 doi: 10.1016/j.prp.2022.154261. PMID: 36527837

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