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Lipohypertrophy

MedGen UID:
226799
•Concept ID:
C1262113
•
Disease or Syndrome

Definition

Hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipohypertrophy

Professional guidelines

PubMed

Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.
Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM
Clin Infect Dis 2017 May 15;64(10):1422-1429. doi: 10.1093/cid/cix178. PMID: 28329372Free PMC Article
Pathogenesis and treatment of HIV lipohypertrophy.
Leung VL, Glesby MJ
Curr Opin Infect Dis 2011 Feb;24(1):43-9. doi: 10.1097/QCO.0b013e3283420eef. PMID: 21124215Free PMC Article
The management of lipohypertrophy in diabetes care.
Hambridge K
Br J Nurs 2007 May 10-23;16(9):520-4. doi: 10.12968/bjon.2007.16.9.23428. PMID: 17551441

Recent clinical studies

Etiology

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Weight gain and integrase inhibitors.
Eckard AR, McComsey GA
Curr Opin Infect Dis 2020 Feb;33(1):10-19. doi: 10.1097/QCO.0000000000000616. PMID: 31789693Free PMC Article
Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.
Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM
Clin Infect Dis 2017 May 15;64(10):1422-1429. doi: 10.1093/cid/cix178. PMID: 28329372Free PMC Article
New Insulin Delivery Recommendations.
Frid AH, Kreugel G, Grassi G, Halimi S, Hicks D, Hirsch LJ, Smith MJ, Wellhoener R, Bode BW, Hirsch IB, Kalra S, Ji L, Strauss KW
Mayo Clin Proc 2016 Sep;91(9):1231-55. doi: 10.1016/j.mayocp.2016.06.010. PMID: 27594187
Prevention of lipohypertrophy.
Kalra S, Kumar A, Gupta Y
J Pak Med Assoc 2016 Jul;66(7):910-1. PMID: 27427150

Diagnosis

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.
Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM
Clin Infect Dis 2017 May 15;64(10):1422-1429. doi: 10.1093/cid/cix178. PMID: 28329372Free PMC Article
Lipohypertrophy.
Kalra S, Jawad F
J Pak Med Assoc 2016 Jun;66(6):779-80. PMID: 27339591
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Therapy

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Cutaneous Manifestations of Diabetes Mellitus: A Review.
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
New Insulin Delivery Recommendations.
Frid AH, Kreugel G, Grassi G, Halimi S, Hicks D, Hirsch LJ, Smith MJ, Wellhoener R, Bode BW, Hirsch IB, Kalra S, Ji L, Strauss KW
Mayo Clin Proc 2016 Sep;91(9):1231-55. doi: 10.1016/j.mayocp.2016.06.010. PMID: 27594187
Lipohypertrophy.
Kalra S, Jawad F
J Pak Med Assoc 2016 Jun;66(6):779-80. PMID: 27339591
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404

Prognosis

Lipohypertrophy and Insulin: An Old Dog That Needs New Tricks.
Huang J, Yeung AM, Kerr D, Gentile S, Heinemann L, Al-Sofiani ME, Joseph JI, Seley JJ, Klonoff DC
Endocr Pract 2023 Aug;29(8):670-677. Epub 2023 Apr 23 doi: 10.1016/j.eprac.2023.04.006. PMID: 37098370
Endocrinological aspects of HIV infection.
Mirza FS, Luthra P, Chirch L
J Endocrinol Invest 2018 Aug;41(8):881-899. Epub 2018 Jan 8 doi: 10.1007/s40618-017-0812-x. PMID: 29313284
Thick legs - not always lipedema.
Reich-Schupke S, Altmeyer P, Stücker M
J Dtsch Dermatol Ges 2013 Mar;11(3):225-33. Epub 2012 Dec 11 doi: 10.1111/ddg.12024. PMID: 23231593
Diabetes mellitus.
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404
HIV-related lipodystrophy and related factors.
Tershakovec AM, Frank I, Rader D
Atherosclerosis 2004 May;174(1):1-10. doi: 10.1016/S0021-9150(03)00246-6. PMID: 15135244

Clinical prediction guides

Skin Involvement in Paediatric Patients with Type 1 Diabetes.
Passanisi S, Salzano G, Lombardo F
Curr Diabetes Rev 2022;18(4):e030921196145. doi: 10.2174/1573399817666210903153837. PMID: 34477525
Subclinical lipohypertrophy--Easily ignored complications of insulin therapy.
Luo D, Shi Y, Zhu M, Wang H, Yan D, Yu J, Ji J, Liu X, Fan B, Xu Y, Zhang M, He W, Xu J, Yang T
J Diabetes Complications 2021 Mar;35(3):107806. Epub 2020 Nov 26 doi: 10.1016/j.jdiacomp.2020.107806. PMID: 33280982
Nanotechnology in Insulin Delivery for Management of Diabetes.
Bahman F, Greish K, Taurin S
Pharm Nanotechnol 2019;7(2):113-128. doi: 10.2174/2211738507666190321110721. PMID: 30907328
Combined treatment of somatostatin analogues with pegvisomant in acromegaly.
Franck SE, Muhammad A, van der Lely AJ, Neggers SJ
Endocrine 2016 May;52(2):206-13. Epub 2015 Dec 10 doi: 10.1007/s12020-015-0810-8. PMID: 26661938Free PMC Article
Pathogenesis and treatment of HIV lipohypertrophy.
Leung VL, Glesby MJ
Curr Opin Infect Dis 2011 Feb;24(1):43-9. doi: 10.1097/QCO.0b013e3283420eef. PMID: 21124215Free PMC Article

Recent systematic reviews

Relationship Between Lipohypertrophy, Glycemic Control, and Insulin Dosing: A Systematic Meta-Analysis.
Mader JK, Fornengo R, Hassoun A, Heinemann L, Kulzer B, Monica M, Nguyen T, Sieber J, Renard E, Reznik Y, Ryś P, Stożek-Tutro A, Wilmot EG
Diabetes Technol Ther 2024 May;26(5):351-362. Epub 2024 Feb 12 doi: 10.1089/dia.2023.0491. PMID: 38215209Free PMC Article
Efficacy of education on injection technique for patients diagnosed with diabetes with lipohypertrophy: systematic review and meta-analysis.
Ichikawa M, Akiyama T, Tsujimoto Y, Anan K, Yamakawa T, Terauchi Y
BMJ Open 2022 Mar 7;12(3):e055529. doi: 10.1136/bmjopen-2021-055529. PMID: 35256444Free PMC Article
Alternative Cosmetic and Medical Applications of Injectable Deoxycholic Acid: A Systematic Review.
Liu C, Li MK, Alster TS
Dermatol Surg 2021 Nov 1;47(11):1466-1472. doi: 10.1097/DSS.0000000000003159. PMID: 34537786
Safety of the reuse of needles for subcutaneous insulin injection: A systematic review and meta-analysis.
Zabaleta-Del-Olmo E, Vlacho B, Jodar-Fernández L, Urpí-Fernández AM, Lumillo-Gutiérrez I, Agudo-Ugena J, Morros-Pedrós R, Violán C
Int J Nurs Stud 2016 Aug;60:121-32. Epub 2016 Apr 27 doi: 10.1016/j.ijnurstu.2016.04.010. PMID: 27297374

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