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Lipoblastoma

MedGen UID:
220362
Concept ID:
C1260965
Neoplastic Process
Synonym: Lipoblastomas
SNOMED CT: Lipoblastoma (63629005); Fetal lipoma (63629005); Lipoblastoma (400102008); Fetal lipoma (400102008); Foetal lipoma (400102008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016611
Orphanet: ORPHA247762

Definition

A rare soft tissue tumor characterized by a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) lesion resembling fetal adipose tissue, composed of mature and immature adipocytes. It is most commonly found during the first years of life and presents as a slowly growing, well circumscribed mass, which may compress adjacent structures, depending on the location. Malignant transformation or metastasis does not occur, while recurrences are described especially in lipoblastomatosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLipoblastoma
Follow this link to review classifications for Lipoblastoma in Orphanet.

Professional guidelines

PubMed

Pérez Daza LD, González Villarreal LC, Sánchez Rodríguez LC, Molina Ramírez ID, Quintero Canasto EM
Pediatr Surg Int 2022 Dec;38(12):2045-2051. Epub 2022 Oct 20 doi: 10.1007/s00383-022-05248-2. PMID: 36264345Free PMC Article
Fallon SC, Brandt ML, Rodriguez JR, Vasudevan SA, Lopez ME, Hicks MJ, Kim ES
J Surg Res 2013 Sep;184(1):341-6. Epub 2013 May 25 doi: 10.1016/j.jss.2013.05.010. PMID: 23751806
Sotelo-Avila C, Bale PM
Pediatr Pathol 1994 Jan-Feb;14(1):39-52. doi: 10.3109/15513819409022024. PMID: 8159619

Recent clinical studies

Etiology

Rajput S, Alsubaie SA, Singh K, Huang TC, Moran SL
J Plast Reconstr Aesthet Surg 2022 Oct;75(10):3761-3767. Epub 2022 Jun 25 doi: 10.1016/j.bjps.2022.06.077. PMID: 36041974
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Alperovich M, Ayo D, Staffenberg DA, Sharma S
J Craniofac Surg 2014;25(2):e189-91. doi: 10.1097/SCS.0000000000000628. PMID: 24621768
Chun YS, Kim WK, Park KW, Lee SC, Jung SE
J Pediatr Surg 2001 Jun;36(6):905-7. doi: 10.1053/jpsu.2001.23969. PMID: 11381423

Diagnosis

Rajput S, Alsubaie SA, Singh K, Huang TC, Moran SL
J Plast Reconstr Aesthet Surg 2022 Oct;75(10):3761-3767. Epub 2022 Jun 25 doi: 10.1016/j.bjps.2022.06.077. PMID: 36041974
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
Choi HJ, Lee YM, Lee JH, Kim JW, Tark MS
J Craniofac Surg 2013;24(5):e507-10. doi: 10.1097/scs.0b013e31828dcf71. PMID: 24163863
Krishnan J, Hathiramani V, Hastak M, Redkar RG
Indian Pediatr 2013 Jun 8;50(6):603-5. PMID: 23942405
Koplin SA, Twohig MH, Lund DP, Hafez GR
Pathol Res Pract 2008;204(4):277-81. Epub 2008 Feb 13 doi: 10.1016/j.prp.2007.10.004. PMID: 18276084

Therapy

Dao D, Najor AJ, Sun PY, Farrokhyar F, Moir CR, Ishitani MB
Pediatr Surg Int 2020 Mar;36(3):341-355. Epub 2020 Jan 14 doi: 10.1007/s00383-019-04612-z. PMID: 31938836
Han JW, Kim H, Youn JK, Oh C, Jung SE, Park KW, Lee SC, Kim HY
Pediatr Hematol Oncol 2017 May;34(4):212-220. Epub 2017 Oct 16 doi: 10.1080/08880018.2017.1354949. PMID: 29035641
García-Montero P, Del Boz J, Sanchez-Martínez M, Escudero Santos IM, Baselga E
Pediatrics 2017 May;139(5) Epub 2017 Apr 12 doi: 10.1542/peds.2016-2105. PMID: 28557723

Prognosis

Chia MRH, Windsor M
ANZ J Surg 2023 Mar;93(3):689-691. Epub 2022 Jul 1 doi: 10.1111/ans.17884. PMID: 35775445
Thway K
Histopathology 2022 Jan;80(1):76-97. doi: 10.1111/his.14548. PMID: 34958506
Abdul-Ghafar J, Ahmad Z, Tariq MU, Kayani N, Uddin N
BMC Res Notes 2018 Jan 17;11(1):42. doi: 10.1186/s13104-018-3153-8. PMID: 29343278Free PMC Article
Choi HJ, Lee YM, Lee JH, Kim JW, Tark MS
J Craniofac Surg 2013;24(5):e507-10. doi: 10.1097/scs.0b013e31828dcf71. PMID: 24163863
Findik G, Gezer S, Sirmali M, Turut H, Aydogdu K, Tastepe I, Karaoglanoglu N, Kaya S
Pediatr Surg Int 2008 Jun;24(6):721-5. Epub 2008 Apr 15 doi: 10.1007/s00383-008-2144-6. PMID: 18414878

Clinical prediction guides

Cao L, Wu Y, Han SM, Sun T, Yu BH, Gao F, Wu WJ, Gao BL
BMC Musculoskelet Disord 2021 Feb 15;22(1):189. doi: 10.1186/s12891-021-04053-7. PMID: 33588810Free PMC Article
Degnan AJ, Jelinek JS, Murphey MD
Pediatr Radiol 2021 Apr;51(4):614-621. Epub 2020 Nov 5 doi: 10.1007/s00247-020-04882-z. PMID: 33151344
Dadone B, Refae S, Lemarié-Delaunay C, Bianchini L, Pedeutour F
Cancer Genet 2015 Oct;208(10):469-81. Epub 2015 Jun 26 doi: 10.1016/j.cancergen.2015.06.005. PMID: 26319758
Nagano A, Ohno T, Nishimoto Y, Hirose Y, Miyake S, Shimizu K
Tohoku J Exp Med 2011 Jan;223(1):75-8. doi: 10.1620/tjem.223.75. PMID: 21212605
Pham NS, Poirier B, Fuller SC, Dublin AB, Tollefson TT
Int J Pediatr Otorhinolaryngol 2010 Jul;74(7):723-8. Epub 2010 May 15 doi: 10.1016/j.ijporl.2010.04.010. PMID: 20472310

Recent systematic reviews

Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314
Lomoro P, Simonetti I, Nanni AL, Corsani G, Togni G, Fichera V, Verde F, Formica M, Trovato P, Vallone G, Gorone MSP
J Ultrasound 2021 Sep;24(3):231-239. Epub 2020 Mar 5 doi: 10.1007/s40477-020-00439-w. PMID: 32141045Free PMC Article
Dao D, Najor AJ, Sun PY, Farrokhyar F, Moir CR, Ishitani MB
Pediatr Surg Int 2020 Mar;36(3):341-355. Epub 2020 Jan 14 doi: 10.1007/s00383-019-04612-z. PMID: 31938836
Pham NS, Poirier B, Fuller SC, Dublin AB, Tollefson TT
Int J Pediatr Otorhinolaryngol 2010 Jul;74(7):723-8. Epub 2010 May 15 doi: 10.1016/j.ijporl.2010.04.010. PMID: 20472310

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