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Compensatory Hyperinsulinemia

MedGen UID:
263472
Concept ID:
C1257965
Disease or Syndrome
Synonym: Hyperinsulinemia, Compensatory

Definition

A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin. [from MeSH]

Professional guidelines

PubMed

Pustotina O, Myers SH, Unfer V, Rasulova I
Gynecol Obstet Invest 2024;89(2):131-139. Epub 2024 Jan 31 doi: 10.1159/000536163. PMID: 38295772Free PMC Article
Muscogiuri G, Barrea L, Campolo F, Sbardella E, Sciammarella C, Tarsitano MG, Bottiglieri F, Colao A, Faggiano A; NIKE
Crit Rev Food Sci Nutr 2022;62(4):1035-1045. Epub 2020 Oct 14 doi: 10.1080/10408398.2020.1832955. PMID: 33938778
Glueck CJ, Goldenberg N
Metabolism 2019 Mar;92:108-120. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.002. PMID: 30445140

Recent clinical studies

Etiology

Pustotina O, Myers SH, Unfer V, Rasulova I
Gynecol Obstet Invest 2024;89(2):131-139. Epub 2024 Jan 31 doi: 10.1159/000536163. PMID: 38295772Free PMC Article
Muscogiuri G, Barrea L, Campolo F, Sbardella E, Sciammarella C, Tarsitano MG, Bottiglieri F, Colao A, Faggiano A; NIKE
Crit Rev Food Sci Nutr 2022;62(4):1035-1045. Epub 2020 Oct 14 doi: 10.1080/10408398.2020.1832955. PMID: 33938778
Pandurevic S, Macut D, Fanelli F, Pagotto U, Gambineri A
Biomolecules 2021 Sep 12;11(9) doi: 10.3390/biom11091350. PMID: 34572562Free PMC Article
Er LK, Wu S, Chou HH, Hsu LA, Teng MS, Sun YC, Ko YL
PLoS One 2016;11(3):e0149731. Epub 2016 Mar 1 doi: 10.1371/journal.pone.0149731. PMID: 26930652Free PMC Article
Ruotolo G, Howard BV
Curr Cardiol Rep 2002 Nov;4(6):494-500. doi: 10.1007/s11886-002-0113-6. PMID: 12379172

Diagnosis

Laudisio D, Muscogiuri G, Barrea L, Savastano S, Colao A
Eur J Obstet Gynecol Reprod Biol 2018 Nov;230:217-221. Epub 2018 Mar 27 doi: 10.1016/j.ejogrb.2018.03.050. PMID: 29730021
Reaven G
Arterioscler Thromb Vasc Biol 2012 Aug;32(8):1754-9. doi: 10.1161/ATVBAHA.111.241885. PMID: 22815340
Suba Z
Pathol Oncol Res 2012 Apr;18(2):123-33. Epub 2011 Oct 9 doi: 10.1007/s12253-011-9466-8. PMID: 21984197
Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R
Nat Rev Endocrinol 2011 Apr;7(4):219-31. Epub 2011 Jan 25 doi: 10.1038/nrendo.2010.217. PMID: 21263450
Ruotolo G, Howard BV
Curr Cardiol Rep 2002 Nov;4(6):494-500. doi: 10.1007/s11886-002-0113-6. PMID: 12379172

Therapy

Pustotina O, Myers SH, Unfer V, Rasulova I
Gynecol Obstet Invest 2024;89(2):131-139. Epub 2024 Jan 31 doi: 10.1159/000536163. PMID: 38295772Free PMC Article
Kosmas CE, Bousvarou MD, Kostara CE, Papakonstantinou EJ, Salamou E, Guzman E
J Int Med Res 2023 Mar;51(3):3000605231164548. doi: 10.1177/03000605231164548. PMID: 36994866Free PMC Article
Laganà AS, Forte G, Bizzarri M, Kamenov ZA, Bianco B, Kaya C, Gitas G, Alkatout I, Terzic M, Unfer V
Expert Opin Drug Metab Toxicol 2022 Feb;18(2):123-133. Epub 2022 May 10 doi: 10.1080/17425255.2022.2071259. PMID: 35472446
Hernández-Jiménez JL, Barrera D, Espinoza-Simón E, González J, Ortíz-Hernández R, Escobar L, Echeverría O, Torres-Ramírez N
Gynecol Endocrinol 2022 Jan;38(1):2-9. Epub 2021 Nov 17 doi: 10.1080/09513590.2021.2003326. PMID: 34787028
Rutkowska AZ, Diamanti-Kandarakis E
Fertil Steril 2016 Sep 15;106(4):948-58. Epub 2016 Aug 22 doi: 10.1016/j.fertnstert.2016.08.031. PMID: 27559705

Prognosis

Pandurevic S, Macut D, Fanelli F, Pagotto U, Gambineri A
Biomolecules 2021 Sep 12;11(9) doi: 10.3390/biom11091350. PMID: 34572562Free PMC Article
Zhu JL, Chen Z, Feng WJ, Long SL, Mo ZC
Clin Chim Acta 2019 Dec;499:142-148. Epub 2019 Sep 13 doi: 10.1016/j.cca.2019.09.010. PMID: 31525346
Vella V, Milluzzo A, Scalisi NM, Vigneri P, Sciacca L
Int J Mol Sci 2018 Nov 16;19(11) doi: 10.3390/ijms19113615. PMID: 30453495Free PMC Article
Bao B, Wang Z, Li Y, Kong D, Ali S, Banerjee S, Ahmad A, Sarkar FH
Biochim Biophys Acta 2011 Apr;1815(2):135-46. Epub 2010 Dec 1 doi: 10.1016/j.bbcan.2010.11.003. PMID: 21129444Free PMC Article
Afonso LC, Edelson GW, Sowers JR
Curr Opin Nephrol Hypertens 1997 May;6(3):219-23. doi: 10.1097/00041552-199705000-00004. PMID: 9263663

Clinical prediction guides

Pustotina O, Myers SH, Unfer V, Rasulova I
Gynecol Obstet Invest 2024;89(2):131-139. Epub 2024 Jan 31 doi: 10.1159/000536163. PMID: 38295772Free PMC Article
Pandurevic S, Macut D, Fanelli F, Pagotto U, Gambineri A
Biomolecules 2021 Sep 12;11(9) doi: 10.3390/biom11091350. PMID: 34572562Free PMC Article
Vella V, Milluzzo A, Scalisi NM, Vigneri P, Sciacca L
Int J Mol Sci 2018 Nov 16;19(11) doi: 10.3390/ijms19113615. PMID: 30453495Free PMC Article
Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R
Nat Rev Endocrinol 2011 Apr;7(4):219-31. Epub 2011 Jan 25 doi: 10.1038/nrendo.2010.217. PMID: 21263450
Afonso LC, Edelson GW, Sowers JR
Curr Opin Nephrol Hypertens 1997 May;6(3):219-23. doi: 10.1097/00041552-199705000-00004. PMID: 9263663

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