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Epidermal necrosis

MedGen UID:
1842160
•Concept ID:
C1167709
•
Pathologic Function
HPO: HP:0034801

Definition

Death of keratinocytes in the epidermis layer of the skin, which generally manifests as extensive exfoliation (separation of the epidermis from the underlying dermis). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidermal necrosis

Professional guidelines

PubMed

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management.
Frantz R, Huang S, Are A, Motaparthi K
Medicina (Kaunas) 2021 Aug 28;57(9) doi: 10.3390/medicina57090895. PMID: 34577817Free PMC Article
A review of toxic epidermal necrolysis management in Japan.
Kinoshita Y, Saeki H
Allergol Int 2017 Jan;66(1):36-41. Epub 2016 Jul 8 doi: 10.1016/j.alit.2016.06.001. PMID: 27400826

Recent clinical studies

Etiology

Blistering and aggressive paniculite cutaneous T-cell lymphoma.
Marín-Hernández E, De-Las-Fuentes-García AD, Siordia-Reyes GA
Bol Med Hosp Infant Mex 2023;80(Supl 1):58-63. doi: 10.24875/BMHIM.22000126. PMID: 37490681
Superior Antihelix Composite Graft for Repair of Nasal Ala and Lateral Nasal Tip Defects: A Retrospective Case Series.
Riopelle AM, Jeong D, Kaliszewski SL, Bald MP, Schanbacher CF
Dermatol Surg 2023 May 1;49(5):466-472. Epub 2023 Mar 13 doi: 10.1097/DSS.0000000000003753. PMID: 36943756
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Vibrio vulnificus septicemia and leg ulcer.
Patel VJ, Gardner E, Burton CS
J Am Acad Dermatol 2002 May;46(5 Suppl):S144-5. doi: 10.1067/mjd.2002.107778. PMID: 12004295
Disseminated fusariosis.
Repiso T, García-Patos V, Martin N, Creus M, Bastida P, Castells A
Pediatr Dermatol 1996 Mar-Apr;13(2):118-21. doi: 10.1111/j.1525-1470.1996.tb01416.x. PMID: 9122067

Diagnosis

Methotrexate-Induced Epidermal Necrosis.
Loesch AJ, Jin A, Huang S, Motaparthi K, Lee JB, Hsu S
Skinmed 2024;22(5):387-389. Epub 2024 Oct 22 PMID: 39433528
Toxic epidermal necrosis-like acute cutaneous lupus erythematosus.
Suzuki K, Saito S, Akiyama M, Kondo Y, Kikuchi J, Hanaoka H, Kaneko Y
Lancet Rheumatol 2024 Apr;6(4):e252. Epub 2023 Sep 27 doi: 10.1016/S2665-9913(23)00154-6. PMID: 38508821
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management.
Frantz R, Huang S, Are A, Motaparthi K
Medicina (Kaunas) 2021 Aug 28;57(9) doi: 10.3390/medicina57090895. PMID: 34577817Free PMC Article
Metabolic epidermal necrosis-hepatocutaneous syndrome.
Byrne KP
Vet Clin North Am Small Anim Pract 1999 Nov;29(6):1337-55. doi: 10.1016/s0195-5616(99)50131-9. PMID: 10563004
Disseminated fusariosis.
Repiso T, García-Patos V, Martin N, Creus M, Bastida P, Castells A
Pediatr Dermatol 1996 Mar-Apr;13(2):118-21. doi: 10.1111/j.1525-1470.1996.tb01416.x. PMID: 9122067

Therapy

Methotrexate-Induced Epidermal Necrosis.
Loesch AJ, Jin A, Huang S, Motaparthi K, Lee JB, Hsu S
Skinmed 2024;22(5):387-389. Epub 2024 Oct 22 PMID: 39433528
Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.
Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723Free PMC Article
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management.
Frantz R, Huang S, Are A, Motaparthi K
Medicina (Kaunas) 2021 Aug 28;57(9) doi: 10.3390/medicina57090895. PMID: 34577817Free PMC Article
Management of toxic epidermal necrolysis.
Craven NM
Hosp Med 2000 Nov;61(11):778-81. doi: 10.12968/hosp.2000.61.11.1463. PMID: 11198746
Disseminated fusariosis.
Repiso T, García-Patos V, Martin N, Creus M, Bastida P, Castells A
Pediatr Dermatol 1996 Mar-Apr;13(2):118-21. doi: 10.1111/j.1525-1470.1996.tb01416.x. PMID: 9122067

Prognosis

Blistering and aggressive paniculite cutaneous T-cell lymphoma.
Marín-Hernández E, De-Las-Fuentes-García AD, Siordia-Reyes GA
Bol Med Hosp Infant Mex 2023;80(Supl 1):58-63. doi: 10.24875/BMHIM.22000126. PMID: 37490681
Management of toxic epidermal necrolysis and related syndromes.
Mukasa Y, Craven N
Postgrad Med J 2008 Feb;84(988):60-5. doi: 10.1136/pgmj.2007.061465. PMID: 18322124
Vibrio vulnificus septicemia and leg ulcer.
Patel VJ, Gardner E, Burton CS
J Am Acad Dermatol 2002 May;46(5 Suppl):S144-5. doi: 10.1067/mjd.2002.107778. PMID: 12004295
Management of toxic epidermal necrolysis.
Craven NM
Hosp Med 2000 Nov;61(11):778-81. doi: 10.12968/hosp.2000.61.11.1463. PMID: 11198746
Metabolic epidermal necrosis-hepatocutaneous syndrome.
Byrne KP
Vet Clin North Am Small Anim Pract 1999 Nov;29(6):1337-55. doi: 10.1016/s0195-5616(99)50131-9. PMID: 10563004

Clinical prediction guides

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: two cases report.
Abdelmouttalib A, Meziane M, Senouci K
Pan Afr Med J 2021;38:236. Epub 2021 Mar 4 doi: 10.11604/pamj.2021.38.236.27303. PMID: 34046141Free PMC Article
Histopathologic Features of Chilblainlike Lesions Developing in the Setting of the Coronavirus Disease 2019 (COVID-19) Pandemic.
Sohier P, Matar S, Meritet JF, Laurent-Roussel S, Dupin N, Aractingi S
Arch Pathol Lab Med 2021 Feb 1;145(2):137-144. doi: 10.5858/arpa.2020-0613-SA. PMID: 33501498
Etanercept therapy for toxic epidermal necrolysis.
Paradisi A, Abeni D, Bergamo F, Ricci F, Didona D, Didona B
J Am Acad Dermatol 2014 Aug;71(2):278-83. Epub 2014 Jun 11 doi: 10.1016/j.jaad.2014.04.044. PMID: 24928706
Metabolic epidermal necrosis-hepatocutaneous syndrome.
Byrne KP
Vet Clin North Am Small Anim Pract 1999 Nov;29(6):1337-55. doi: 10.1016/s0195-5616(99)50131-9. PMID: 10563004

Recent systematic reviews

Methotrexate Cutaneous Ulceration: A Systematic Review of Cases.
Berna R, Rosenbach M, Margolis DJ, Mitra N, Baumrin E
Am J Clin Dermatol 2022 Jul;23(4):449-457. Epub 2022 Apr 29 doi: 10.1007/s40257-022-00692-1. PMID: 35486323
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Intravenous immunoglobulin for the treatment of toxic epidermal necrolysis: a systematic review and meta-analysis.
Huang YC, Chien YN, Chen YT, Li YC, Chen TJ
G Ital Dermatol Venereol 2016 Oct;151(5):515-24. Epub 2016 Jun 1 PMID: 27248150
A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children.
Del Pozzo-Magana BR, Lazo-Langner A, Carleton B, Castro-Pastrana LI, Rieder MJ
J Popul Ther Clin Pharmacol 2011;18:e121-33. Epub 2011 Mar 21 PMID: 21467603

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