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Gastrointestinal hypomotility

MedGen UID:
679237
•Concept ID:
C0948779
•
Disease or Syndrome
SNOMED CT: Gastrointestinal hypomotility (421807004)

Professional guidelines

PubMed

Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment.
Xu Y, Amdanee N, Zhang X
CNS Drugs 2021 Dec;35(12):1265-1274. Epub 2021 Aug 24 doi: 10.1007/s40263-021-00859-0. PMID: 34427901
Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases.
Manu P, Lapitskaya Y, Shaikh A, Nielsen J
Am J Ther 2018 Mar/Apr;25(2):e218-e223. doi: 10.1097/MJT.0000000000000715. PMID: 29505490
Prevention and treatment of gastrointestinal complications in patients on mechanical ventilation.
Mutlu GM, Mutlu EA, Factor P
Am J Respir Med 2003;2(5):395-411. doi: 10.1007/BF03256667. PMID: 14719992

Recent clinical studies

Etiology

Serum Metabolic Profile in Schizophrenia Patients With Antipsychotic-Induced Constipation and Its relationship With Gut Microbiome.
Amdanee N, Shao M, Hu X, Fang X, Zhou C, Chen J, Ridwan Chattun M, Wen L, Pan X, Zhang X, Xu Y
Schizophr Bull 2023 May 3;49(3):646-658. doi: 10.1093/schbul/sbac202. PMID: 36723169Free PMC Article
Antipsychotic-induced gastrointestinal hypomotility and the alteration in gut microbiota in patients with schizophrenia.
Xu Y, Shao M, Fang X, Tang W, Zhou C, Hu X, Zhang X, Su KP
Brain Behav Immun 2022 Jan;99:119-129. Epub 2021 Sep 24 doi: 10.1016/j.bbi.2021.09.014. PMID: 34563620
Risk of gastrointestinal Hypomotility in schizophrenia and schizoaffective disorder treated with antipsychotics: A retrospective cohort study.
Chen HK, Hsieh CJ
Schizophr Res 2018 May;195:237-244. Epub 2017 Oct 27 doi: 10.1016/j.schres.2017.10.024. PMID: 29107449
Clozapine induced gastrointestinal hypomotility: A potentially life threatening adverse event. A review of the literature.
West S, Rowbotham D, Xiong G, Kenedi C
Gen Hosp Psychiatry 2017 May;46:32-37. Epub 2017 Feb 28 doi: 10.1016/j.genhosppsych.2017.02.004. PMID: 28622812
Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 cases.
Palmer SE, McLean RM, Ellis PM, Harrison-Woolrych M
J Clin Psychiatry 2008 May;69(5):759-68. doi: 10.4088/jcp.v69n0509. PMID: 18452342

Diagnosis

Serum Metabolic Profile in Schizophrenia Patients With Antipsychotic-Induced Constipation and Its relationship With Gut Microbiome.
Amdanee N, Shao M, Hu X, Fang X, Zhou C, Chen J, Ridwan Chattun M, Wen L, Pan X, Zhang X, Xu Y
Schizophr Bull 2023 May 3;49(3):646-658. doi: 10.1093/schbul/sbac202. PMID: 36723169Free PMC Article
Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment.
Xu Y, Amdanee N, Zhang X
CNS Drugs 2021 Dec;35(12):1265-1274. Epub 2021 Aug 24 doi: 10.1007/s40263-021-00859-0. PMID: 34427901
Focussing on the fundaments - assessing and treating Clozapine Induced Gastrointestinal Hypomotility.
Blackman G, Kapila A, Grosskopf CM, Dratcu L
Int J Psychiatry Clin Pract 2020 Mar;24(1):18-19. Epub 2020 Jan 7 doi: 10.1080/13651501.2019.1710538. PMID: 31910056
Risk of gastrointestinal Hypomotility in schizophrenia and schizoaffective disorder treated with antipsychotics: A retrospective cohort study.
Chen HK, Hsieh CJ
Schizophr Res 2018 May;195:237-244. Epub 2017 Oct 27 doi: 10.1016/j.schres.2017.10.024. PMID: 29107449
Clozapine induced gastrointestinal hypomotility: A potentially life threatening adverse event. A review of the literature.
West S, Rowbotham D, Xiong G, Kenedi C
Gen Hosp Psychiatry 2017 May;46:32-37. Epub 2017 Feb 28 doi: 10.1016/j.genhosppsych.2017.02.004. PMID: 28622812

Therapy

Antipsychotic-induced gastrointestinal hypomotility and the alteration in gut microbiota in patients with schizophrenia.
Xu Y, Shao M, Fang X, Tang W, Zhou C, Hu X, Zhang X, Su KP
Brain Behav Immun 2022 Jan;99:119-129. Epub 2021 Sep 24 doi: 10.1016/j.bbi.2021.09.014. PMID: 34563620
Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment.
Xu Y, Amdanee N, Zhang X
CNS Drugs 2021 Dec;35(12):1265-1274. Epub 2021 Aug 24 doi: 10.1007/s40263-021-00859-0. PMID: 34427901
Clozapine and Gastrointestinal Hypomotility.
Cohen D
CNS Drugs 2017 Dec;31(12):1083-1091. doi: 10.1007/s40263-017-0481-5. PMID: 29230675
Clozapine induced gastrointestinal hypomotility: A potentially life threatening adverse event. A review of the literature.
West S, Rowbotham D, Xiong G, Kenedi C
Gen Hosp Psychiatry 2017 May;46:32-37. Epub 2017 Feb 28 doi: 10.1016/j.genhosppsych.2017.02.004. PMID: 28622812
Erythromycin and the gut.
Catnach SM, Fairclough PD
Gut 1992 Mar;33(3):397-401. doi: 10.1136/gut.33.3.397. PMID: 1568663Free PMC Article

Prognosis

High Burden of Ileus and Pneumonia in Clozapine-Treated Individuals With Schizophrenia: A Finnish 25-Year Follow-Up Register Study.
Partanen JJ, Häppölä P, Kämpe A, Ahola-Olli A, Hellsten A, Rask SM, Haaki W, Hietala J, Kampman O, Tiihonen J, Tanskanen AJ; FinnGen; SUPER-Finland, Daly MJ, Ripatti S, Palotie A, Taipale H, Lähteenvuo M, Koskela JT
Am J Psychiatry 2024 Oct 1;181(10):879-892. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230744. PMID: 39262212
Predictors of laxative use in inpatients with schizophrenia on clozapine.
Sazhin V, Pushkal P
Australas Psychiatry 2022 Feb;30(1):105-109. Epub 2021 Oct 27 doi: 10.1177/10398562211042368. PMID: 34702103
Risk of gastrointestinal Hypomotility in schizophrenia and schizoaffective disorder treated with antipsychotics: A retrospective cohort study.
Chen HK, Hsieh CJ
Schizophr Res 2018 May;195:237-244. Epub 2017 Oct 27 doi: 10.1016/j.schres.2017.10.024. PMID: 29107449
Clozapine and Gastrointestinal Hypomotility.
Cohen D
CNS Drugs 2017 Dec;31(12):1083-1091. doi: 10.1007/s40263-017-0481-5. PMID: 29230675
Beyond white blood cell monitoring: screening in the initial phase of clozapine therapy.
Cohen D, Bogers JP, van Dijk D, Bakker B, Schulte PF
J Clin Psychiatry 2012 Oct;73(10):1307-12. doi: 10.4088/JCP.11r06977. PMID: 23140648

Clinical prediction guides

High Burden of Ileus and Pneumonia in Clozapine-Treated Individuals With Schizophrenia: A Finnish 25-Year Follow-Up Register Study.
Partanen JJ, Häppölä P, Kämpe A, Ahola-Olli A, Hellsten A, Rask SM, Haaki W, Hietala J, Kampman O, Tiihonen J, Tanskanen AJ; FinnGen; SUPER-Finland, Daly MJ, Ripatti S, Palotie A, Taipale H, Lähteenvuo M, Koskela JT
Am J Psychiatry 2024 Oct 1;181(10):879-892. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230744. PMID: 39262212
Predictors of laxative use in inpatients with schizophrenia on clozapine.
Sazhin V, Pushkal P
Australas Psychiatry 2022 Feb;30(1):105-109. Epub 2021 Oct 27 doi: 10.1177/10398562211042368. PMID: 34702103
Antipsychotic-induced gastrointestinal hypomotility and the alteration in gut microbiota in patients with schizophrenia.
Xu Y, Shao M, Fang X, Tang W, Zhou C, Hu X, Zhang X, Su KP
Brain Behav Immun 2022 Jan;99:119-129. Epub 2021 Sep 24 doi: 10.1016/j.bbi.2021.09.014. PMID: 34563620
Constipation screening in people taking clozapine: A diagnostic accuracy study.
Every-Palmer S, Inns SJ, Ellis PM
Schizophr Res 2020 Jun;220:179-186. Epub 2020 Apr 1 doi: 10.1016/j.schres.2020.03.032. PMID: 32245597
Beyond white blood cell monitoring: screening in the initial phase of clozapine therapy.
Cohen D, Bogers JP, van Dijk D, Bakker B, Schulte PF
J Clin Psychiatry 2012 Oct;73(10):1307-12. doi: 10.4088/JCP.11r06977. PMID: 23140648

Recent systematic reviews

Recognition and management of clozapine adverse effects: A systematic review and qualitative synthesis.
Gurrera RJ, Gearin PF, Love J, Li KJ, Xu A, Donaghey FH, Gerace MR
Acta Psychiatr Scand 2022 May;145(5):423-441. Epub 2022 Mar 16 doi: 10.1111/acps.13406. PMID: 35178700
Erythromycin as a prokinetic agent in preterm neonates: a systematic review.
Patole S, Rao S, Doherty D
Arch Dis Child Fetal Neonatal Ed 2005 Jul;90(4):F301-6. Epub 2005 May 17 doi: 10.1136/adc.2004.065250. PMID: 15899929Free PMC Article

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