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Carcinogenesis, Radiation

MedGen UID:
183091
•Concept ID:
C0920372
•
Neoplastic Process
Synonyms: Radiation / Carcinogenesis; Radiation Carcinogenesis

Definition

The study of the processes by which normal cells, exposed to ionizing radiation, are transformed into cancer cells. [from NCI]

Professional guidelines

PubMed

Estimation of Second Primary Cancer Risk After Treatment with Radioactive Iodine for Differentiated Thyroid Carcinoma.
Corrêa NL, de Sá LV, de Mello RC
Thyroid 2017 Feb;27(2):261-270. Epub 2016 Nov 21 doi: 10.1089/thy.2016.0266. PMID: 27762670
Accuracy of out-of-field dose calculation of tomotherapy and cyberknife treatment planning systems: a dosimetric study.
Schneider U, Hälg RA, Hartmann M, Mack A, Storelli F, Joosten A, Möckli R, Besserer J
Z Med Phys 2014 Sep;24(3):211-5. Epub 2013 Nov 28 doi: 10.1016/j.zemedi.2013.10.008. PMID: 24290992
Science and trans-science in radiation risk assessment: child cancer around the nuclear fuel reprocessing plant at Sellafield, U.K.
Crouch D
Sci Total Environ 1986 Sep;53(3):201-16. doi: 10.1016/0048-9697(86)90133-6. PMID: 3764411

Recent clinical studies

Etiology

Glaucomagenesis following ionizing radiation exposure.
Hamada N, Azizova TV, Little MP
Mutat Res Rev Mutat Res 2019 Jan-Mar;779:36-44. Epub 2019 Jan 8 doi: 10.1016/j.mrrev.2019.01.001. PMID: 31097150Free PMC Article
Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations.
Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM
J Am Acad Dermatol 2019 Feb;80(2):303-317. Epub 2018 May 18 doi: 10.1016/j.jaad.2018.03.060. PMID: 29782900
Focus on cutaneous and uveal melanoma specificities.
Pandiani C, Béranger GE, Leclerc J, Ballotti R, Bertolotto C
Genes Dev 2017 Apr 15;31(8):724-743. doi: 10.1101/gad.296962.117. PMID: 28512236Free PMC Article
Photocarcinogenesis and Skin Cancer Prevention Strategies.
Seebode C, Lehmann J, Emmert S
Anticancer Res 2016 Mar;36(3):1371-8. PMID: 26977038
Changing Attitude Toward Radiation Carcinogenesis and Prospects for Novel Low-Dose Radiation Treatments.
Socol Y, Welsh JS
Technol Cancer Res Treat 2016 Dec;15(6):732-736. Epub 2015 Sep 21 doi: 10.1177/1533034615605639. PMID: 26391015

Diagnosis

The Role of the Apoptotic Machinery in Ionizing Radiation-Induced Carcinogenesis.
Balcer-Kubiczek EK
Crit Rev Oncog 2016;21(3-4):169-184. doi: 10.1615/CritRevOncog.2016016984. PMID: 27915970
Photocarcinogenesis and Skin Cancer Prevention Strategies.
Seebode C, Lehmann J, Emmert S
Anticancer Res 2016 Mar;36(3):1371-8. PMID: 26977038
Changing Attitude Toward Radiation Carcinogenesis and Prospects for Novel Low-Dose Radiation Treatments.
Socol Y, Welsh JS
Technol Cancer Res Treat 2016 Dec;15(6):732-736. Epub 2015 Sep 21 doi: 10.1177/1533034615605639. PMID: 26391015
Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation.
Sridharan DM, Asaithamby A, Bailey SM, Costes SV, Doetsch PW, Dynan WS, Kronenberg A, Rithidech KN, Saha J, Snijders AM, Werner E, Wiese C, Cucinotta FA, Pluth JM
Radiat Res 2015 Jan;183(1):1-26. Epub 2015 Jan 7 doi: 10.1667/RR13804.1. PMID: 25564719
Radiation-induced microRNA: discovery, functional analysis, and cancer radiotherapy.
Chaudhry MA
J Cell Biochem 2014 Mar;115(3):436-49. doi: 10.1002/jcb.24694. PMID: 24129925

Therapy

Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations.
Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM
J Am Acad Dermatol 2019 Feb;80(2):303-317. Epub 2018 May 18 doi: 10.1016/j.jaad.2018.03.060. PMID: 29782900
Sunscreens: An Update.
Mancuso JB, Maruthi R, Wang SQ, Lim HW
Am J Clin Dermatol 2017 Oct;18(5):643-650. doi: 10.1007/s40257-017-0290-0. PMID: 28510141
Photocarcinogenesis and Skin Cancer Prevention Strategies.
Seebode C, Lehmann J, Emmert S
Anticancer Res 2016 Mar;36(3):1371-8. PMID: 26977038
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium.
Kim ES, Kim JE, Patel MA, Mangraviti A, Ruzevick J, Lim M
J Immunol Res 2016;2016:4683607. Epub 2016 Jan 4 doi: 10.1155/2016/4683607. PMID: 26881264Free PMC Article
Nicotinamide and the skin.
Chen AC, Damian DL
Australas J Dermatol 2014 Aug;55(3):169-75. Epub 2014 Mar 17 doi: 10.1111/ajd.12163. PMID: 24635573

Prognosis

Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid.
Matsuu-Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M
Sci Rep 2021 Sep 27;11(1):19096. doi: 10.1038/s41598-021-98481-z. PMID: 34580369Free PMC Article
Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations.
Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, Nehal KS, Rossi AM
J Am Acad Dermatol 2019 Feb;80(2):303-317. Epub 2018 May 18 doi: 10.1016/j.jaad.2018.03.060. PMID: 29782900
Biologically-based mechanistic models of radiation-related carcinogenesis applied to epidemiological data.
Rühm W, Eidemüller M, Kaiser JC
Int J Radiat Biol 2017 Oct;93(10):1093-1117. Epub 2017 Apr 25 doi: 10.1080/09553002.2017.1310405. PMID: 28346027
Changing Attitude Toward Radiation Carcinogenesis and Prospects for Novel Low-Dose Radiation Treatments.
Socol Y, Welsh JS
Technol Cancer Res Treat 2016 Dec;15(6):732-736. Epub 2015 Sep 21 doi: 10.1177/1533034615605639. PMID: 26391015
Solar ultraviolet radiation from cancer induction to cancer prevention: solar ultraviolet radiation and cell biology.
Tuorkey MJ
Eur J Cancer Prev 2015 Sep;24(5):430-8. doi: 10.1097/CEJ.0000000000000181. PMID: 26075659

Clinical prediction guides

Biologically-based mechanistic models of radiation-related carcinogenesis applied to epidemiological data.
Rühm W, Eidemüller M, Kaiser JC
Int J Radiat Biol 2017 Oct;93(10):1093-1117. Epub 2017 Apr 25 doi: 10.1080/09553002.2017.1310405. PMID: 28346027
Irradiance-dependent UVB Photocarcinogenesis.
Lan CE, Wu CS, Huang SM, Wu CH, Lai HC, Peng YT, Hou PS, Yang HJ, Chen GS
Sci Rep 2016 Nov 21;6:37403. doi: 10.1038/srep37403. PMID: 27869214Free PMC Article
Changing Attitude Toward Radiation Carcinogenesis and Prospects for Novel Low-Dose Radiation Treatments.
Socol Y, Welsh JS
Technol Cancer Res Treat 2016 Dec;15(6):732-736. Epub 2015 Sep 21 doi: 10.1177/1533034615605639. PMID: 26391015
DNA damage in cancer therapeutics: a boon or a curse?
Khanna A
Cancer Res 2015 Jun 1;75(11):2133-8. Epub 2015 Apr 30 doi: 10.1158/0008-5472.CAN-14-3247. PMID: 25931285
Origin of the linearity no threshold (LNT) dose-response concept.
Calabrese EJ
Arch Toxicol 2013 Sep;87(9):1621-33. Epub 2013 Jul 26 doi: 10.1007/s00204-013-1104-7. PMID: 23887208

Recent systematic reviews

A Systematic Review on the In Vivo Studies on Radiofrequency (100 kHz-300 GHz) Electromagnetic Field Exposure and Co-Carcinogenesis.
Pinto R, Ardoino L, Giardullo P, Villani P, Marino C
Int J Environ Res Public Health 2024 Aug 2;21(8) doi: 10.3390/ijerph21081020. PMID: 39200630Free PMC Article

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