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Candidemia

MedGen UID:
163760
•Concept ID:
C0877445
•
Disease or Syndrome
Synonyms: candidemia; Candidemias
SNOMED CT: Candidemia (432261003)
 
Monarch Initiative: MONDO:0044070

Definition

A form of invasive candidiasis where species of candida are present in the blood. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCandidemia

Professional guidelines

PubMed

Diagnosis and Treatment of Candidemia in the Intensive Care Unit.
Bassetti M, Giacobbe DR, Vena A, Wolff M
Semin Respir Crit Care Med 2019 Aug;40(4):524-539. Epub 2019 Oct 4 doi: 10.1055/s-0039-1693704. PMID: 31585478
ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients.
Martin-Loeches I, Antonelli M, Cuenca-Estrella M, Dimopoulos G, Einav S, De Waele JJ, Garnacho-Montero J, Kanj SS, Machado FR, Montravers P, Sakr Y, Sanguinetti M, Timsit JF, Bassetti M
Intensive Care Med 2019 Jun;45(6):789-805. Epub 2019 Mar 25 doi: 10.1007/s00134-019-05599-w. PMID: 30911804
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD
Clin Infect Dis 2016 Feb 15;62(4):e1-50. Epub 2015 Dec 16 doi: 10.1093/cid/civ933. PMID: 26679628Free PMC Article

Recent clinical studies

Etiology

Candida parapsilosis complex in the clinical setting.
Govrins M, Lass-Flörl C
Nat Rev Microbiol 2024 Jan;22(1):46-59. Epub 2023 Sep 6 doi: 10.1038/s41579-023-00961-8. PMID: 37674021
Prevalence, risk factors, treatment and outcome of multidrug resistance Candida auris infections in Coronavirus disease (COVID-19) patients: A systematic review.
Vinayagamoorthy K, Pentapati KC, Prakash H
Mycoses 2022 Jun;65(6):613-624. doi: 10.1111/myc.13447. PMID: 35441748Free PMC Article
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
Candidemia in Colombia.
Cortés JA, Ruiz JF, Melgarejo-Moreno LN, Lemos EV
Biomedica 2020 Mar 1;40(1):195-207. doi: 10.7705/biomedica.4400. PMID: 32220174Free PMC Article
Candidemia in the patient with malignancy.
Alves J, Palma P, Azevedo D, Rello J
Hosp Pract (1995) 2018 Dec;46(5):246-252. Epub 2018 Aug 13 doi: 10.1080/21548331.2018.1508290. PMID: 30079788

Diagnosis

Candida parapsilosis complex in the clinical setting.
Govrins M, Lass-Flörl C
Nat Rev Microbiol 2024 Jan;22(1):46-59. Epub 2023 Sep 6 doi: 10.1038/s41579-023-00961-8. PMID: 37674021
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
Biomarkers of fungal infection: Expert opinion on the current situation.
Bouza E, Almirante B, García Rodríguez J, Garnacho-Montero J, Salavert M, Muñoz P, Sanguinetti M
Rev Esp Quimioter 2020 Feb;33(1):1-10. Epub 2019 Nov 14 doi: 10.37201/req/2260.2019. PMID: 31729203Free PMC Article
Diagnosis and Treatment of Candidemia in the Intensive Care Unit.
Bassetti M, Giacobbe DR, Vena A, Wolff M
Semin Respir Crit Care Med 2019 Aug;40(4):524-539. Epub 2019 Oct 4 doi: 10.1055/s-0039-1693704. PMID: 31585478
Candidemia and invasive candidiasis in adults: A narrative review.
Antinori S, Milazzo L, Sollima S, Galli M, Corbellino M
Eur J Intern Med 2016 Oct;34:21-28. Epub 2016 Jul 7 doi: 10.1016/j.ejim.2016.06.029. PMID: 27394927

Therapy

Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
Rezafungin: a novel antifungal for the treatment of invasive candidiasis.
Ham YY, Lewis JS 2nd, Thompson GR 3rd
Future Microbiol 2021 Jan;16(1):27-36. doi: 10.2217/fmb-2020-0217. PMID: 33438477
Diagnosis and Treatment of Candidemia in the Intensive Care Unit.
Bassetti M, Giacobbe DR, Vena A, Wolff M
Semin Respir Crit Care Med 2019 Aug;40(4):524-539. Epub 2019 Oct 4 doi: 10.1055/s-0039-1693704. PMID: 31585478
ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.
Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll AH, Skiada A, Lass-Flörl C, Calandra T, Viscoli C, Herbrecht R
Haematologica 2017 Mar;102(3):433-444. Epub 2016 Dec 23 doi: 10.3324/haematol.2016.152900. PMID: 28011902Free PMC Article
Candidemia and invasive candidiasis in adults: A narrative review.
Antinori S, Milazzo L, Sollima S, Galli M, Corbellino M
Eur J Intern Med 2016 Oct;34:21-28. Epub 2016 Jul 7 doi: 10.1016/j.ejim.2016.06.029. PMID: 27394927

Prognosis

Fungal infections in Algeria.
Aissat FZ, Denning DW
Mycoses 2023 Jul;66(7):594-603. Epub 2023 Apr 2 doi: 10.1111/myc.13585. PMID: 37005355
American Academy of Ophthalmology Recommendations on Screening for Endogenous Candida Endophthalmitis.
Breazzano MP, Bond JB 3rd, Bearelly S, Kim DH, Donahue SP, Lum F, Olsen TW; American Academy of Ophthalmology
Ophthalmology 2022 Jan;129(1):73-76. Epub 2021 Jul 19 doi: 10.1016/j.ophtha.2021.07.015. PMID: 34293405
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
The Changing Epidemiology of Invasive Fungal Infections.
Enoch DA, Yang H, Aliyu SH, Micallef C
Methods Mol Biol 2017;1508:17-65. doi: 10.1007/978-1-4939-6515-1_2. PMID: 27837497
Candida and candidaemia. Susceptibility and epidemiology.
Arendrup MC
Dan Med J 2013 Nov;60(11):B4698. PMID: 24192246

Clinical prediction guides

Candida albicans and Candida glabrata: global priority pathogens.
Katsipoulaki M, Stappers MHT, Malavia-Jones D, Brunke S, Hube B, Gow NAR
Microbiol Mol Biol Rev 2024 Jun 27;88(2):e0002123. Epub 2024 Jun 4 doi: 10.1128/mmbr.00021-23. PMID: 38832801Free PMC Article
Detailed β-(1→3)-D-glucan and mannan antigen kinetics in patients with candidemia.
Träger J, Dräger S, Mihai S, Cipa F, Busse Grawitz A, Epting T, Meyer R, Rappold E, Held J
J Clin Microbiol 2023 Nov 21;61(11):e0059823. Epub 2023 Oct 12 doi: 10.1128/jcm.00598-23. PMID: 37823667Free PMC Article
Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study.
Hoenigl M, Salmanton-García J, Egger M, Gangneux JP, Bicanic T, Arikan-Akdagli S, Alastruey-Izquierdo A, Klimko N, Barac A, Özenci V, Meijer EFJ, Khanna N, Bassetti M, Rautemaa-Richardson R, Lagrou K, Adam KM, Akalin EH, Akova M, Arsic Arsenijevic V, Aujayeb A, Blennow O, Bretagne S, Danion F, Denis B, de Jonge NA, Desoubeaux G, Drgona L, Erben N, Gori A, García Rodríguez J, Garcia-Vidal C, Giacobbe DR, Goodman AL, Hamal P, Hammarström H, Toscano C, Lanternier F, Lass-Flörl C, Lockhart DEA, Longval T, Loughlin L, Matos T, Mikulska M, Narayanan M, Martín-Pérez S, Prattes J, Rogers B, Rahimli L, Ruiz M, Roilides E, Samarkos M, Scharmann U, Sili U, Sipahi OR, Sivakova A, Steinmann J, Trauth J, Turhan O, Van Praet J, Vena A, White PL, Willinger B, Tortorano AM, Arendrup MC, Koehler P, Cornely OA; ECMM Candida III Study Group
Lancet Infect Dis 2023 Jun;23(6):751-761. Epub 2023 Feb 15 doi: 10.1016/S1473-3099(22)00872-6. PMID: 37254300
Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG
Clin Infect Dis 2021 Dec 6;73(11):e3647-e3655. doi: 10.1093/cid/ciaa1380. PMID: 32955088Free PMC Article
Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial.
Kullberg BJ, Viscoli C, Pappas PG, Vazquez J, Ostrosky-Zeichner L, Rotstein C, Sobel JD, Herbrecht R, Rahav G, Jaruratanasirikul S, Chetchotisakd P, Van Wijngaerden E, De Waele J, Lademacher C, Engelhardt M, Kovanda L, Croos-Dabrera R, Fredericks C, Thompson GR
Clin Infect Dis 2019 May 30;68(12):1981-1989. doi: 10.1093/cid/ciy827. PMID: 30289478

Recent systematic reviews

Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis.
Phongkhun K, Pothikamjorn T, Srisurapanont K, Manothummetha K, Sanguankeo A, Thongkam A, Chuleerarux N, Leksuwankun S, Meejun T, Thanakitcharu J, Walker M, Gopinath S, Torvorapanit P, Langsiri N, Worasilchai N, Moonla C, Plongla R, Kates OS, Nematollahi S, Permpalung N
Clin Infect Dis 2023 May 24;76(10):1738-1749. doi: 10.1093/cid/ciad064. PMID: 36750934Free PMC Article
Comparative efficacy and safety of systemic antifungal agents for candidemia: a systematic review with network meta-analysis and multicriteria acceptability analyses.
Domingos EL, Vilhena RO, Santos JMMF, Fachi MM, Böger B, Adam LM, Tonin FS, Pontarolo R
Int J Antimicrob Agents 2022 Aug;60(2):106614. Epub 2022 Jun 9 doi: 10.1016/j.ijantimicag.2022.106614. PMID: 35691603
Prevalence, risk factors, treatment and outcome of multidrug resistance Candida auris infections in Coronavirus disease (COVID-19) patients: A systematic review.
Vinayagamoorthy K, Pentapati KC, Prakash H
Mycoses 2022 Jun;65(6):613-624. doi: 10.1111/myc.13447. PMID: 35441748Free PMC Article
Candida auris: A systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen.
Osei Sekyere J
Microbiologyopen 2018 Aug;7(4):e00578. Epub 2018 Jan 18 doi: 10.1002/mbo3.578. PMID: 29345117Free PMC Article
Epidemiological and mycological characteristics of candidemia in Iran: A systematic review and meta-analysis.
Vaezi A, Fakhim H, Khodavaisy S, Alizadeh A, Nazeri M, Soleimani A, Boekhout T, Badali H
J Mycol Med 2017 Jun;27(2):146-152. Epub 2017 Mar 16 doi: 10.1016/j.mycmed.2017.02.007. PMID: 28318900

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