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Decreased erythroid precursor production

MedGen UID:
164082
•Concept ID:
C0877221
•
Disease or Syndrome
Synonym: Erythroblastopenia
SNOMED CT: Decreased erythroid precursor production (420510009); Erythroblastopenia (420510009)

Professional guidelines

PubMed

Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.
Bianchi N, Finotti A, Ferracin M, Lampronti I, Zuccato C, Breveglieri G, Brognara E, Fabbri E, Borgatti M, Negrini M, Gambari R
PLoS One 2015;10(4):e0121567. Epub 2015 Apr 7 doi: 10.1371/journal.pone.0121567. PMID: 25849663Free PMC Article
Cessation of intensive treatment with recombinant human erythropoietin is followed by secondary anemia.
Piron M, Loo M, Gothot A, Tassin F, Fillet G, Beguin Y
Blood 2001 Jan 15;97(2):442-8. doi: 10.1182/blood.v97.2.442. PMID: 11154221
Diamond-blackfan anemia: etiology, pathophysiology, and treatment.
Halperin DS, Freedman MH
Am J Pediatr Hematol Oncol 1989 Winter;11(4):380-94. PMID: 2694854

Recent clinical studies

Etiology

Proteomics screening uncovers HMGA1 as a promising negative regulator for γ-globin expression in response to decreased β-globin levels.
Zhou G, Lu D
J Proteomics 2023 Aug 30;286:104957. Epub 2023 Jul 7 doi: 10.1016/j.jprot.2023.104957. PMID: 37423548
Recent advances in the understanding of inherited sideroblastic anaemia.
Camaschella C
Br J Haematol 2008 Oct;143(1):27-38. Epub 2008 Jul 14 doi: 10.1111/j.1365-2141.2008.07290.x. PMID: 18637800
What is antibody-mediated pure red cell aplasia (PRCA)?
Casadevall N
Nephrol Dial Transplant 2005 May;20 Suppl 4:iv3-8. doi: 10.1093/ndt/gfh1088. PMID: 15827056
Increased apoptosis in acquired sideroblastic anaemia.
Matthes TW, Meyer G, Samii K, Beris P
Br J Haematol 2000 Dec;111(3):843-52. PMID: 11122146
Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes.
Silverman LR, Holland JF, Weinberg RS, Alter BP, Davis RB, Ellison RR, Demakos EP, Cornell CJ Jr, Carey RW, Schiffer C
Leukemia 1993 May;7 Suppl 1:21-9. PMID: 7683352

Diagnosis

Parvovirus b19 infection in children with sickle cell disease, watch out for splenomegaly! A case report.
de la Hoz JA, Otones LL, Sáenz MH, Martín MJR
Afr Health Sci 2022 Mar;22(1):598-601. doi: 10.4314/ahs.v22i1.69. PMID: 36032454Free PMC Article
Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation.
Hyeon S, Lee H, Yang Y, Jeong W
Free Radic Biol Med 2013 Dec;65:789-799. Epub 2013 Aug 14 doi: 10.1016/j.freeradbiomed.2013.08.005. PMID: 23954472
Recent advances in the understanding of inherited sideroblastic anaemia.
Camaschella C
Br J Haematol 2008 Oct;143(1):27-38. Epub 2008 Jul 14 doi: 10.1111/j.1365-2141.2008.07290.x. PMID: 18637800
Anemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza F, Beguin Y, Bergmann P, André M, Ferster A, Devalck C, Fondu P, Buyse M, Sariban E
Blood 1998 Sep 1;92(5):1793-8. PMID: 9716610
Clonality assays and megakaryocyte culture techniques in essential thrombocythemia.
Yan L, Elkassar N, Gardin C, Briere J
Leuk Lymphoma 1996 Sep;22 Suppl 1:31-40. doi: 10.3109/10428199609074358. PMID: 8951770

Therapy

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.
Zurlo M, Zuccato C, Cosenza LC, Gasparello J, Gamberini MR, Stievano A, Fortini M, Prosdocimi M, Finotti A, Gambari R
Int J Mol Sci 2023 Oct 10;24(20) doi: 10.3390/ijms242015049. PMID: 37894732Free PMC Article
Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease.
Koury MJ, Agarwal R, Chertow GM, Eckardt KU, Fishbane S, Ganz T, Haase VH, Hanudel MR, Parfrey PS, Pergola PE, Roy-Chaudhury P, Tumlin JA, Anders R, Farag YMK, Luo W, Minga T, Solinsky C, Vargo DL, Winkelmayer WC
Am J Hematol 2022 Sep;97(9):1178-1188. Epub 2022 Jul 15 doi: 10.1002/ajh.26644. PMID: 35751858Free PMC Article
Recent advances in the understanding of inherited sideroblastic anaemia.
Camaschella C
Br J Haematol 2008 Oct;143(1):27-38. Epub 2008 Jul 14 doi: 10.1111/j.1365-2141.2008.07290.x. PMID: 18637800
Red blood cell physiology in critical illness.
Scharte M, Fink MP
Crit Care Med 2003 Dec;31(12 Suppl):S651-7. doi: 10.1097/01.CCM.0000098036.90796.ED. PMID: 14724462
Diamond-blackfan anemia: etiology, pathophysiology, and treatment.
Halperin DS, Freedman MH
Am J Pediatr Hematol Oncol 1989 Winter;11(4):380-94. PMID: 2694854

Prognosis

Redistribution of iron towards deposits in erythroblastopenic anemia as a consequence of decreased erythroferrone production.
Cucuianu A, Patiu M, Trifa AP, Tomuleasa C, Dima D
Med Hypotheses 2014 Nov;83(5):530-2. Epub 2014 Sep 18 doi: 10.1016/j.mehy.2014.09.008. PMID: 25267320
Anaemia of cancer: an overview of mechanisms involved in its pathogenesis.
Grotto HZ
Med Oncol 2008;25(1):12-21. Epub 2007 Sep 2 doi: 10.1007/s12032-007-9000-8. PMID: 18188710
What is antibody-mediated pure red cell aplasia (PRCA)?
Casadevall N
Nephrol Dial Transplant 2005 May;20 Suppl 4:iv3-8. doi: 10.1093/ndt/gfh1088. PMID: 15827056
Pathophysiology of intensive care unit-acquired anemia.
Fink MP
Crit Care 2004;8 Suppl 2(Suppl 2):S9-10. Epub 2004 Jun 14 doi: 10.1186/cc2410. PMID: 15196314Free PMC Article
Diamond-blackfan anemia: etiology, pathophysiology, and treatment.
Halperin DS, Freedman MH
Am J Pediatr Hematol Oncol 1989 Winter;11(4):380-94. PMID: 2694854

Clinical prediction guides

Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor.
Kralova B, Sochorcova L, Song J, Jahoda O, Hlusickova Kapralova K, Prchal JT, Divoky V, Horvathova M
Am J Hematol 2022 Oct;97(10):1286-1299. Epub 2022 Jul 23 doi: 10.1002/ajh.26658. PMID: 35815815
Nitric Oxide Synthase Dependency in Hydroxyurea Inhibition of Erythroid Progenitor Growth.
Subotički T, Ajtić OM, Đikić D, Santibanez JF, Tošić M, Čokić VP
Genes (Basel) 2021 Jul 27;12(8) doi: 10.3390/genes12081145. PMID: 34440315Free PMC Article
What is antibody-mediated pure red cell aplasia (PRCA)?
Casadevall N
Nephrol Dial Transplant 2005 May;20 Suppl 4:iv3-8. doi: 10.1093/ndt/gfh1088. PMID: 15827056
Clonality assays and megakaryocyte culture techniques in essential thrombocythemia.
Yan L, Elkassar N, Gardin C, Briere J
Leuk Lymphoma 1996 Sep;22 Suppl 1:31-40. doi: 10.3109/10428199609074358. PMID: 8951770
Role of erythropoietin in adaptation to hypoxia.
Scholz H, Schurek HJ, Eckardt KU, Bauer C
Experientia 1990 Dec 1;46(11-12):1197-201. doi: 10.1007/BF01936936. PMID: 2253723

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