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Seizures, afebrile

MedGen UID:
209024
•Concept ID:
C0863106
•
Disease or Syndrome
Synonym: Afebrile seizures

Professional guidelines

PubMed

Genotype and phenotype analysis of epilepsy caused by ADGRV1 mutations in Chinese children.
Leng X, Zhang T, Guan Y, Tang M
Seizure 2022 Dec;103:108-114. Epub 2022 Nov 11 doi: 10.1016/j.seizure.2022.11.005. PMID: 36399868
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Nickels K, Kossoff EH, Eschbach K, Joshi C
Epilepsia 2021 Jan;62(1):120-127. Epub 2020 Nov 14 doi: 10.1111/epi.16752. PMID: 33190223
Febrile seizures: current concepts concerning prognosis and clinical management.
Applegate MS, Lo W
J Fam Pract 1989 Oct;29(4):422-8. PMID: 2677213

Recent clinical studies

Etiology

First afebrile seizures: Clinical and radiological view with emergent testing.
Aksu Uzunhan T, Kaçar A, Mısırlı Özdemir E, Yapıcı Ö
Pediatr Int 2022 Jan;64(1):e15089. doi: 10.1111/ped.15089. PMID: 34882919
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Nickels K, Kossoff EH, Eschbach K, Joshi C
Epilepsia 2021 Jan;62(1):120-127. Epub 2020 Nov 14 doi: 10.1111/epi.16752. PMID: 33190223
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M
Brain 2019 Aug 1;142(8):2303-2318. doi: 10.1093/brain/awz195. PMID: 31302675Free PMC Article
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158
Febrile seizures.
Gorman RJ, Snead OC
Am Fam Physician 1979 Jan;19(1):101-4. PMID: 760419

Diagnosis

Case 314.
Garg P, Bajaj S, Sharma AK, Narang P, Bansal K
Radiology 2023 Feb;306(2):e220111. doi: 10.1148/radiol.220111. PMID: 36689346
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Nickels K, Kossoff EH, Eschbach K, Joshi C
Epilepsia 2021 Jan;62(1):120-127. Epub 2020 Nov 14 doi: 10.1111/epi.16752. PMID: 33190223
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M
Brain 2019 Aug 1;142(8):2303-2318. doi: 10.1093/brain/awz195. PMID: 31302675Free PMC Article
Dravet syndrome and its mimics: Beyond SCN1A.
Steel D, Symonds JD, Zuberi SM, Brunklaus A
Epilepsia 2017 Nov;58(11):1807-1816. Epub 2017 Sep 7 doi: 10.1111/epi.13889. PMID: 28880996
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158

Therapy

First afebrile seizures: Clinical and radiological view with emergent testing.
Aksu Uzunhan T, Kaçar A, Mısırlı Özdemir E, Yapıcı Ö
Pediatr Int 2022 Jan;64(1):e15089. doi: 10.1111/ped.15089. PMID: 34882919
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Nickels K, Kossoff EH, Eschbach K, Joshi C
Epilepsia 2021 Jan;62(1):120-127. Epub 2020 Nov 14 doi: 10.1111/epi.16752. PMID: 33190223
PCDH19-Related Epilepsy Syndrome: A Comprehensive Clinical Review.
Samanta D
Pediatr Neurol 2020 Apr;105:3-9. Epub 2019 Nov 30 doi: 10.1016/j.pediatrneurol.2019.10.009. PMID: 32057594
Febrile seizures.
Mewasingh LD
BMJ Clin Evid 2014 Jan 31;2014 PMID: 24484859Free PMC Article
Afebrile pediatric seizures.
Sharieff GQ, Hendry PL
Emerg Med Clin North Am 2011 Feb;29(1):95-108. doi: 10.1016/j.emc.2010.08.009. PMID: 21109106

Prognosis

First afebrile seizures: Clinical and radiological view with emergent testing.
Aksu Uzunhan T, Kaçar A, Mısırlı Özdemir E, Yapıcı Ö
Pediatr Int 2022 Jan;64(1):e15089. doi: 10.1111/ped.15089. PMID: 34882919
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort.
Nickels K, Kossoff EH, Eschbach K, Joshi C
Epilepsia 2021 Jan;62(1):120-127. Epub 2020 Nov 14 doi: 10.1111/epi.16752. PMID: 33190223
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M
Brain 2019 Aug 1;142(8):2303-2318. doi: 10.1093/brain/awz195. PMID: 31302675Free PMC Article
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158
Afebrile benign convulsions with mild gastroenteritis: a new entity?
Verrotti A, Tocco AM, Coppola GG, Altobelli E, Chiarelli F
Acta Neurol Scand 2009 Aug;120(2):73-9. Epub 2009 May 6 doi: 10.1111/j.1600-0404.2008.01154.x. PMID: 19432878

Clinical prediction guides

Case 314.
Garg P, Bajaj S, Sharma AK, Narang P, Bansal K
Radiology 2023 Feb;306(2):e220111. doi: 10.1148/radiol.220111. PMID: 36689346
Clinical predictors of drug-resistant epilepsy in children.
Karaoğlu P, Yaş U, Polat Aİ, Ayanoğlu M, Hız S
Turk J Med Sci 2021 Jun 28;51(3):1249-1252. doi: 10.3906/sag-2010-27. PMID: 33600098Free PMC Article
Clinical spectrum of STX1B-related epileptic disorders.
Wolking S, May P, Mei D, Møller RS, Balestrini S, Helbig KL, Altuzarra CD, Chatron N, Kaiwar C, Stöhr K, Widdess-Walsh P, Mendelsohn BA, Numis A, Cilio MR, Van Paesschen W, Svendsen LL, Oates S, Hughes E, Goyal S, Brown K, Sifuentes Saenz M, Dorn T, Muhle H, Pagnamenta AT, Vavoulis DV, Knight SJL, Taylor JC, Canevini MP, Darra F, Gavrilova RH, Powis Z, Tang S, Marquetand J, Armstrong M, McHale D, Klee EW, Kluger GJ, Lowenstein DH, Weckhuysen S, Pal DK, Helbig I, Guerrini R, Thomas RH, Rees MI, Lesca G, Sisodiya SM, Weber YG, Lal D, Marini C, Lerche H, Schubert J
Neurology 2019 Mar 12;92(11):e1238-e1249. Epub 2019 Feb 8 doi: 10.1212/WNL.0000000000007089. PMID: 30737342Free PMC Article
The core Dravet syndrome phenotype.
Dravet C
Epilepsia 2011 Apr;52 Suppl 2:3-9. doi: 10.1111/j.1528-1167.2011.02994.x. PMID: 21463272
Fever, genes, and epilepsy.
Baulac S, Gourfinkel-An I, Nabbout R, Huberfeld G, Serratosa J, Leguern E, Baulac M
Lancet Neurol 2004 Jul;3(7):421-30. doi: 10.1016/S1474-4422(04)00808-7. PMID: 15207799

Recent systematic reviews

Febrile seizures.
Mewasingh LD
BMJ Clin Evid 2014 Jan 31;2014 PMID: 24484859Free PMC Article

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