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Malignant epithelioid mesothelioma

MedGen UID:
163578
•Concept ID:
C0862312
•
Neoplastic Process
Synonyms: Epithelial Mesothelioma; epithelial mesothelioma; Epithelioid Mesothelioma; Epithelioid mesothelioma; epithelioid mesothelioma; Epithelioid mesothelioma, malignant; epithelioid mesothelioma, malignant; epithelioid mesothelioma, malignant (morphologic abnormality); Malignant Epithelial Mesothelioma; malignant epithelial mesothelioma; malignant epithelioid mesothelioma
SNOMED CT: Epithelioid mesothelioma, malignant (65278006); Epithelioid mesothelioma (65278006); Malignant epithelioid mesothelioma (65278006)
 
Monarch Initiative: MONDO:0005599

Definition

A malignant neoplasm arising from mesothelial cells. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns. [from NCI]

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.
Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma.
Giger-Pabst U, Demtröder C, Falkenstein TA, Ouaissi M, Götze TO, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 18;18(1):442. doi: 10.1186/s12885-018-4363-0. PMID: 29669524Free PMC Article
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Safety and Feasibility of High-Pressure/High-Dose Pressurized Intraperitoneal Aerosol Chemotherapy (HP/HD-PIPAC) for Primary and Metastatic Peritoneal Surface Malignancies.
Ramos Arias G, Sindayigaya R, Ouaissi M, Buggisch JR, Schmeding M, Giger-Pabst U, Zieren J
Ann Surg Oncol 2023 Apr;30(4):2497-2505. Epub 2022 Nov 18 doi: 10.1245/s10434-022-12698-4. PMID: 36400887
Histopathological typing in diffuse malignant epithelioid mesothelioma: implication for prognosis and molecular basis.
Forest F, Laville D, Habougit C, Corbasson M, Bayle-Bleuez S, Tissot C, Fournel P, Tiffet O, Péoc'h M
Pathology 2021 Oct;53(6):728-734. Epub 2021 May 6 doi: 10.1016/j.pathol.2021.01.010. PMID: 33965253
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma.
Giger-Pabst U, Demtröder C, Falkenstein TA, Ouaissi M, Götze TO, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 18;18(1):442. doi: 10.1186/s12885-018-4363-0. PMID: 29669524Free PMC Article

Diagnosis

Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis.
Parra-Medina R, Castañeda-González JP, Chaves-Cabezas V, Alzate JP, Chaves JJ
Pathol Res Pract 2024 May;257:155276. Epub 2024 Mar 30 doi: 10.1016/j.prp.2024.155276. PMID: 38603842
Histopathological typing in diffuse malignant epithelioid mesothelioma: implication for prognosis and molecular basis.
Forest F, Laville D, Habougit C, Corbasson M, Bayle-Bleuez S, Tissot C, Fournel P, Tiffet O, Péoc'h M
Pathology 2021 Oct;53(6):728-734. Epub 2021 May 6 doi: 10.1016/j.pathol.2021.01.010. PMID: 33965253
Distant cutaneous metastasis of malignant epithelioid mesothelioma.
Collins K, Nagarajan P, Aung PP
J Cutan Pathol 2021 Jul;48(7):902-907. Epub 2020 Dec 14 doi: 10.1111/cup.13927. PMID: 33258154
Aberrant Pax-8 expression in well-differentiated papillary mesothelioma and malignant mesothelioma of the peritoneum: a clinicopathologic study.
Xing D, Banet N, Sharma R, Vang R, Ronnett BM, Illei PB
Hum Pathol 2018 Feb;72:160-166. Epub 2017 Dec 11 doi: 10.1016/j.humpath.2017.10.036. PMID: 29241740
Deciduoid mesothelioma of the thorax: A comprehensive review of the scientific literature.
Paliogiannis P, Putzu C, Ginesu GC, Cossu ML, Feo CF, Attene F, Scognamillo F, Nonnis R, Cossu A, Palmieri G, Pirina P, Fois A
Clin Respir J 2018 Mar;12(3):848-856. Epub 2017 Jan 6 doi: 10.1111/crj.12599. PMID: 28026144

Therapy

Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis.
Parra-Medina R, Castañeda-González JP, Chaves-Cabezas V, Alzate JP, Chaves JJ
Pathol Res Pract 2024 May;257:155276. Epub 2024 Mar 30 doi: 10.1016/j.prp.2024.155276. PMID: 38603842
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma.
Giger-Pabst U, Demtröder C, Falkenstein TA, Ouaissi M, Götze TO, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 18;18(1):442. doi: 10.1186/s12885-018-4363-0. PMID: 29669524Free PMC Article
Deciduoid mesothelioma of the thorax: A comprehensive review of the scientific literature.
Paliogiannis P, Putzu C, Ginesu GC, Cossu ML, Feo CF, Attene F, Scognamillo F, Nonnis R, Cossu A, Palmieri G, Pirina P, Fois A
Clin Respir J 2018 Mar;12(3):848-856. Epub 2017 Jan 6 doi: 10.1111/crj.12599. PMID: 28026144
Deciduoid mesothelioma of the pleura in an adolescent boy.
Tsai LY, Yang YL, Lu MY, Lin DT, Huang HY, Lin KH
Pediatr Hematol Oncol 2010 Mar;27(2):132-7. doi: 10.3109/08880010903447359. PMID: 20201694
Fine-needle aspiration of a well-differentiated papillary mesothelioma in the inguinal hernia sac: A case report and review of literature.
Wheeler YY, Burroughs F, Li QK
Diagn Cytopathol 2009 Oct;37(10):748-54. doi: 10.1002/dc.21084. PMID: 19373910

Prognosis

Histopathological typing in diffuse malignant epithelioid mesothelioma: implication for prognosis and molecular basis.
Forest F, Laville D, Habougit C, Corbasson M, Bayle-Bleuez S, Tissot C, Fournel P, Tiffet O, Péoc'h M
Pathology 2021 Oct;53(6):728-734. Epub 2021 May 6 doi: 10.1016/j.pathol.2021.01.010. PMID: 33965253
Distant cutaneous metastasis of malignant epithelioid mesothelioma.
Collins K, Nagarajan P, Aung PP
J Cutan Pathol 2021 Jul;48(7):902-907. Epub 2020 Dec 14 doi: 10.1111/cup.13927. PMID: 33258154
Deciduoid mesothelioma of the thorax: A comprehensive review of the scientific literature.
Paliogiannis P, Putzu C, Ginesu GC, Cossu ML, Feo CF, Attene F, Scognamillo F, Nonnis R, Cossu A, Palmieri G, Pirina P, Fois A
Clin Respir J 2018 Mar;12(3):848-856. Epub 2017 Jan 6 doi: 10.1111/crj.12599. PMID: 28026144
Minimal change disease associated with malignant pleural mesothelioma: case report and review of the literature.
Yildiz H, Andreea SI, Hoton D, Yombi JC
BMJ Case Rep 2016 Dec 19;2016 doi: 10.1136/bcr-2016-217958. PMID: 27993826Free PMC Article
EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors.
Kothmaier H, Quehenberger F, Halbwedl I, Morbini P, Demirag F, Zeren H, Comin CE, Murer B, Cagle PT, Attanoos R, Gibbs AR, Galateau-Salle F, Popper HH
Thorax 2008 Apr;63(4):345-51. Epub 2007 Dec 17 doi: 10.1136/thx.2007.085241. PMID: 18086752

Clinical prediction guides

Safety and Feasibility of High-Pressure/High-Dose Pressurized Intraperitoneal Aerosol Chemotherapy (HP/HD-PIPAC) for Primary and Metastatic Peritoneal Surface Malignancies.
Ramos Arias G, Sindayigaya R, Ouaissi M, Buggisch JR, Schmeding M, Giger-Pabst U, Zieren J
Ann Surg Oncol 2023 Apr;30(4):2497-2505. Epub 2022 Nov 18 doi: 10.1245/s10434-022-12698-4. PMID: 36400887
Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma.
Giger-Pabst U, Demtröder C, Falkenstein TA, Ouaissi M, Götze TO, Rezniczek GA, Tempfer CB
BMC Cancer 2018 Apr 18;18(1):442. doi: 10.1186/s12885-018-4363-0. PMID: 29669524Free PMC Article
Expression of "myelomonocytic" antigens in mesotheliomas and adenocarcinomas involving the serosal surfaces.
Wick MR, Mills SE, Swanson PE
Am J Clin Pathol 1990 Jul;94(1):18-26. doi: 10.1093/ajcp/94.1.18. PMID: 1694390

Recent systematic reviews

Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis.
Parra-Medina R, Castañeda-González JP, Chaves-Cabezas V, Alzate JP, Chaves JJ
Pathol Res Pract 2024 May;257:155276. Epub 2024 Mar 30 doi: 10.1016/j.prp.2024.155276. PMID: 38603842

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