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B Lymphoblastic Leukemia/Lymphoma

MedGen UID:
163575
Concept ID:
C0862030
Neoplastic Process
Synonyms: B lymphoblastic leukemia lymphoma; B-Cell Lymphoblastic Leukemia/Lymphoma; B-Lymphoblastic Leukemia/Lymphoma; Precursor B Lymphoblastic Leukemia/Lymphoma; Precursor B-Lymphoblastic Lymphoma/Leukemia
SNOMED CT: B lymphoblastic leukemia lymphoma (1162660006)

Definition

A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Lymphoblastic Leukemia/Lymphoma

Professional guidelines

PubMed

McGregor S, McNeer J, Gurbuxani S
Semin Diagn Pathol 2012 Feb;29(1):2-11. doi: 10.1053/j.semdp.2011.07.004. PMID: 22372201Free PMC Article
Desouki MM, Post GR, Cherry D, Lazarchick J
Clin Med Res 2010 Jul;8(2):84-8. doi: 10.3121/cmr.2010.891. PMID: 20660931Free PMC Article

Recent clinical studies

Etiology

Chen X, Gao Q, Roshal M, Cherian S
Cytometry B Clin Cytom 2023 May;104(3):205-223. Epub 2023 Jan 22 doi: 10.1002/cyto.b.22113. PMID: 36683279
Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Zhou Y, You MJ, Young KH, Lin P, Lu G, Medeiros LJ, Bueso-Ramos CE
Hum Pathol 2012 Sep;43(9):1347-62. Epub 2012 May 8 doi: 10.1016/j.humpath.2012.02.004. PMID: 22575265
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Diagnosis

Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Siegele BJ, Nardi V
Am J Hematol 2018 Jul;93(7):971-977. Epub 2018 May 15 doi: 10.1002/ajh.25126. PMID: 29696694
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Therapy

Rahim S, Ahmad Z, Chundriger Q, Ahmed A, Ali N, Abdul-Ghafar J
World J Surg Oncol 2023 Feb 27;21(1):63. doi: 10.1186/s12957-023-02956-4. PMID: 36843105Free PMC Article
Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627
Matynia AP, Perkins SL, Li D
Fetal Pediatr Pathol 2018 Feb;37(1):7-14. Epub 2018 Jan 16 doi: 10.1080/15513815.2017.1379042. PMID: 29336635
Geethakumari PR, Hoffmann MS, Pemmaraju N, Hu S, Jorgensen JL, O'Brien S, Daver N
Clin Lymphoma Myeloma Leuk 2014 Aug;14(4):e115-8. Epub 2014 Feb 2 doi: 10.1016/j.clml.2014.01.004. PMID: 24589157Free PMC Article
Trimaldi J, Carballido EM, Bowers JW, Anguiano AL, Zhang ZJ, Shah BD, Bruno S, List AF, Moscinski LC, Grady T, Agosti SJ, Kang L, Zhang L
Acta Haematol 2013;130(3):127-34. Epub 2013 Apr 16 doi: 10.1159/000347030. PMID: 23594707

Prognosis

Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627
Meng X, Min Q, Wang JY
Adv Exp Med Biol 2020;1254:161-181. doi: 10.1007/978-981-15-3532-1_12. PMID: 32323276
Conant JL, Czuchlewski DR
Int J Lab Hematol 2019 May;41 Suppl 1:126-130. doi: 10.1111/ijlh.13012. PMID: 31069976
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Clinical prediction guides

Chatterjee G, Dhende P, Raj S, Shetty V, Ghogale S, Deshpande N, Girase K, Patil J, Kalra A, Narula G, Dalvi K, Dhamne C, Moulik NR, Rajpal S, Patkar NV, Banavali S, Gujral S, Subramanian PG, Tembhare PR
Eur J Haematol 2024 Jan;112(1):122-136. Epub 2023 Sep 14 doi: 10.1111/ejh.14102. PMID: 37706583
Gao Q, Liu Y, Aypar U, Baik J, Londono D, Sun X, Zhang J, Zhang Y, Roshal M
Cytometry B Clin Cytom 2023 Jul;104(4):279-293. Epub 2023 Mar 30 doi: 10.1002/cyto.b.22120. PMID: 36999235Free PMC Article
Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD Jr, Fuda FS, Chen W, Jaso JM
Am J Clin Pathol 2020 Nov 4;154(6):816-827. doi: 10.1093/ajcp/aqaa109. PMID: 32880627
Pournazari P, Padmore RF, Kosari F, Scalia P, Shahbani-Rad MT, Shariff S, Demetrick DJ, Bosch M, Mansoor A
Hum Pathol 2014 Aug;45(8):1582-7. Epub 2014 Apr 18 doi: 10.1016/j.humpath.2013.11.024. PMID: 24856976
Zhou Y, You MJ, Young KH, Lin P, Lu G, Medeiros LJ, Bueso-Ramos CE
Hum Pathol 2012 Sep;43(9):1347-62. Epub 2012 May 8 doi: 10.1016/j.humpath.2012.02.004. PMID: 22575265

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