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Resectable Pancreatic Adenocarcinoma

MedGen UID:
1651806
•Concept ID:
C0861748
•
Neoplastic Process

Definition

Pancreatic adenocarcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Pancreatic Adenocarcinoma

Professional guidelines

PubMed

Multimodality management of borderline resectable pancreatic adenocarcinoma.
Prakash LR, Katz MHG
Chin Clin Oncol 2017 Jun;6(3):27. doi: 10.21037/cco.2017.06.17. PMID: 28705004
Multimodal treatment of resectable pancreatic ductal adenocarcinoma.
Silvestris N, Brunetti O, Vasile E, Cellini F, Cataldo I, Pusceddu V, Cattaneo M, Partelli S, Scartozzi M, Aprile G, Casadei Gardini A, Morganti AG, Valentini V, Scarpa A, Falconi M, Calabrese A, Lorusso V, Reni M, Cascinu S
Crit Rev Oncol Hematol 2017 Mar;111:152-165. Epub 2017 Feb 4 doi: 10.1016/j.critrevonc.2017.01.015. PMID: 28259290
ACR Appropriateness Criteria® Resectable Pancreatic Cancer.
Jones WE 3rd, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, Small W Jr, Herman JM; Expert Panel on Radiation OncologyGastrointestinal
Am J Clin Oncol 2017 Apr;40(2):109-117. doi: 10.1097/COC.0000000000000370. PMID: 28230650Free PMC Article

Recent clinical studies

Etiology

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial.
Nicolle R, Bachet JB, Harlé A, Iovanna J, Hammel P, Rebours V, Turpin A, Ben Abdelghani M, Wei A, Mitry E, Lopez A, Biagi J, François E, Artru P, Lambert A, Renouf DJ, Monard L, Mauduit M, Dusetti N, Conroy T, Cros J
J Clin Oncol 2024 Mar 20;42(9):1067-1076. Epub 2023 Nov 14 doi: 10.1200/JCO.22.02668. PMID: 37963313Free PMC Article
Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Pancreatic Adenocarcinoma: An Updated Nationwide Study.
Sugawara T, Rodriguez Franco S, Sherman S, Torphy RJ, Colborn K, Franklin O, Ishida J, Grandi S, Al-Musawi MH, Gleisner A, Schulick RD, Del Chiaro M
Ann Surg 2024 Feb 1;279(2):331-339. Epub 2023 May 25 doi: 10.1097/SLA.0000000000005925. PMID: 37226812
Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS
JAMA Oncol 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. PMID: 33475684Free PMC Article
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Multimodality management of borderline resectable pancreatic adenocarcinoma.
Prakash LR, Katz MHG
Chin Clin Oncol 2017 Jun;6(3):27. doi: 10.21037/cco.2017.06.17. PMID: 28705004

Diagnosis

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial.
Nicolle R, Bachet JB, Harlé A, Iovanna J, Hammel P, Rebours V, Turpin A, Ben Abdelghani M, Wei A, Mitry E, Lopez A, Biagi J, François E, Artru P, Lambert A, Renouf DJ, Monard L, Mauduit M, Dusetti N, Conroy T, Cros J
J Clin Oncol 2024 Mar 20;42(9):1067-1076. Epub 2023 Nov 14 doi: 10.1200/JCO.22.02668. PMID: 37963313Free PMC Article
Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Pancreatic Adenocarcinoma: An Updated Nationwide Study.
Sugawara T, Rodriguez Franco S, Sherman S, Torphy RJ, Colborn K, Franklin O, Ishida J, Grandi S, Al-Musawi MH, Gleisner A, Schulick RD, Del Chiaro M
Ann Surg 2024 Feb 1;279(2):331-339. Epub 2023 May 25 doi: 10.1097/SLA.0000000000005925. PMID: 37226812
Current status of pancreatic cancer with oligometastasis.
Chapa-Azuela Ó, Corona-Torres MJ, Ayala-Moreno EA, Arroyo-Paredes PS, Pérez-Torres E, Rodríguez-Báez A, Montalvo-Javé EE
Cir Cir 2023;91(2):262-267. doi: 10.24875/CIRU.22000364. PMID: 37084317
Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS
JAMA Oncol 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. PMID: 33475684Free PMC Article
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article

Therapy

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial.
Nicolle R, Bachet JB, Harlé A, Iovanna J, Hammel P, Rebours V, Turpin A, Ben Abdelghani M, Wei A, Mitry E, Lopez A, Biagi J, François E, Artru P, Lambert A, Renouf DJ, Monard L, Mauduit M, Dusetti N, Conroy T, Cros J
J Clin Oncol 2024 Mar 20;42(9):1067-1076. Epub 2023 Nov 14 doi: 10.1200/JCO.22.02668. PMID: 37963313Free PMC Article
Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS
JAMA Oncol 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. PMID: 33475684Free PMC Article
Advances in borderline resectable pancreatic adenocarcinoma.
Vadehra D, Salibi PN, McHaffie DR, Sulzer J, Iannitti DA, Hwang JJ
Clin Adv Hematol Oncol 2020 May;18(5):280-288. PMID: 32628656
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Perioperative Therapy for Surgically Resectable Pancreatic Adenocarcinoma.
Du L, DeFoe M, Ruzinova MB, Olsen JR, Wang-Gillam A
Hematol Oncol Clin North Am 2015 Aug;29(4):717-26. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.011. PMID: 26226906Free PMC Article

Prognosis

Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial.
Nicolle R, Bachet JB, Harlé A, Iovanna J, Hammel P, Rebours V, Turpin A, Ben Abdelghani M, Wei A, Mitry E, Lopez A, Biagi J, François E, Artru P, Lambert A, Renouf DJ, Monard L, Mauduit M, Dusetti N, Conroy T, Cros J
J Clin Oncol 2024 Mar 20;42(9):1067-1076. Epub 2023 Nov 14 doi: 10.1200/JCO.22.02668. PMID: 37963313Free PMC Article
Focus on Therapeutic Options for Surgically Resectable Pancreatic Adenocarcinoma Based on Novel Biomarkers.
Olivari A, Agnetti V, Garajová I
Curr Oncol 2023 Jul 6;30(7):6462-6472. doi: 10.3390/curroncol30070475. PMID: 37504335Free PMC Article
Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma: A Phase 2 Clinical Trial.
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Perioperative Therapy for Surgically Resectable Pancreatic Adenocarcinoma.
Du L, DeFoe M, Ruzinova MB, Olsen JR, Wang-Gillam A
Hematol Oncol Clin North Am 2015 Aug;29(4):717-26. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.011. PMID: 26226906Free PMC Article
Pancreatic surgery in France.
Partensky C
Surg Today 2010 Oct;40(10):895-901. Epub 2010 Sep 25 doi: 10.1007/s00595-010-4352-7. PMID: 20872190

Clinical prediction guides

Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma - analysis from SWOG S1505.
Sohal DPS, Boutin RD, Lenchik L, Kim J, Beg MS, Wang-Gillam A, Wade JL 3rd, Guthrie KA, Chiorean EG, Ahmad SA, Lowy AM, Philip PA, Chang VT
J Gastrointest Surg 2024 Mar;28(3):232-235. Epub 2024 Jan 19 doi: 10.1016/j.gassur.2023.12.022. PMID: 38445914
Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial.
Nicolle R, Bachet JB, Harlé A, Iovanna J, Hammel P, Rebours V, Turpin A, Ben Abdelghani M, Wei A, Mitry E, Lopez A, Biagi J, François E, Artru P, Lambert A, Renouf DJ, Monard L, Mauduit M, Dusetti N, Conroy T, Cros J
J Clin Oncol 2024 Mar 20;42(9):1067-1076. Epub 2023 Nov 14 doi: 10.1200/JCO.22.02668. PMID: 37963313Free PMC Article
Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Pancreatic Adenocarcinoma: An Updated Nationwide Study.
Sugawara T, Rodriguez Franco S, Sherman S, Torphy RJ, Colborn K, Franklin O, Ishida J, Grandi S, Al-Musawi MH, Gleisner A, Schulick RD, Del Chiaro M
Ann Surg 2024 Feb 1;279(2):331-339. Epub 2023 May 25 doi: 10.1097/SLA.0000000000005925. PMID: 37226812
Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.
Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS
JAMA Oncol 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. PMID: 33475684Free PMC Article
Perioperative Therapy for Surgically Resectable Pancreatic Adenocarcinoma.
Du L, DeFoe M, Ruzinova MB, Olsen JR, Wang-Gillam A
Hematol Oncol Clin North Am 2015 Aug;29(4):717-26. Epub 2015 May 30 doi: 10.1016/j.hoc.2015.04.011. PMID: 26226906Free PMC Article

Recent systematic reviews

The Oncological Stress Test of Neoadjuvant Therapy: A Systematic Review in Outcomes of Neoadjuvant Therapy Compared to Upfront Resection Approach for Borderline Resectable Pancreatic Adenocarcinoma.
Ross SB, Popover J, Sucandy I, Christodoulou M, Pattilachan TM, Rosemurgy AS
Am Surg 2024 Nov;90(11):3061-3073. Epub 2024 Apr 18 doi: 10.1177/00031348241248703. PMID: 38635295
Significance of indeterminate pulmonary nodules in resectable pancreatic adenocarcinoma-a review.
Kuan LL, Dennison AR, Garcea G
Langenbecks Arch Surg 2021 May;406(3):537-545. Epub 2021 Jan 3 doi: 10.1007/s00423-020-02049-w. PMID: 33392814Free PMC Article
Efficacy of Neo-Adjuvant Chemoradiotherapy for Resectable Pancreatic Adenocarcinoma: A PRISMA-Compliant Meta-Analysis and Systematic Review.
Liu W, Fu XL, Yang JY, Liu DJ, Li J, Zhang JF, Huo YM, Yang MW, Hua R, Sun YW
Medicine (Baltimore) 2016 Apr;95(15):e3009. doi: 10.1097/MD.0000000000003009. PMID: 27082545Free PMC Article
A systematic review of the role of periadventitial dissection of the superior mesenteric artery in affecting margin status after pancreatoduodenectomy for pancreatic adenocarcinoma.
Butler JR, Ahmad SA, Katz MH, Cioffi JL, Zyromski NJ
HPB (Oxford) 2016 Apr;18(4):305-11. Epub 2016 Feb 1 doi: 10.1016/j.hpb.2015.11.009. PMID: 27037198Free PMC Article
Is adjuvant 5-FU-based chemoradiotherapy for resectable pancreatic adenocarcinoma beneficial? A meta-analysis of an unanswered question.
Khanna A, Walker GR, Livingstone AS, Arheart KL, Rocha-Lima C, Koniaris LG
J Gastrointest Surg 2006 May;10(5):689-97. doi: 10.1016/j.gassur.2005.11.006. PMID: 16713541

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