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Drug-induced liver injury

MedGen UID:
163652
Concept ID:
C0860207
Disease or Syndrome
Synonyms: Disease, Drug-Induced Liver; Diseases, Drug-Induced Liver; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Liver Disease; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Drug-Induced Liver Injury; Injuries, Drug-Induced Liver; Injury, Drug-Induced Liver; Liver Disease, Drug-Induced; Liver Diseases, Drug-Induced; Liver Injuries, Drug-Induced; Liver Injury, Drug Induced; Liver Injury, Drug-Induced
SNOMED CT: Drug-induced disorder of liver (427399008); Drug induced hepatotoxicity (427399008)
 
Monarch Initiative: MONDO:0005359

Definition

Damage to the liver tissue due to drug overdose. [from NCI]

Professional guidelines

PubMed

Andrade RJ, Aithal GP, de Boer YS, Liberal R, Gerbes A, Regev A, Terziroli Beretta-Piccoli B, Schramm C, Kleiner DE, De Martin E, Kullak-Ublick GA, Stirnimann G, Devarbhavi H, Vierling JM, Manns MP, Sebode M, Londoño MC, Avigan M, Robles-Diaz M, García-Cortes M, Atallah E, Heneghan M, Chalasani N, Trivedi PJ, Hayashi PH, Taubert R, Fontana RJ, Weber S, Oo YH, Zen Y, Licata A, Lucena MI, Mieli-Vergani G, Vergani D, Björnsson ES; IAIHG and EASL DHILI Consortium
J Hepatol 2023 Sep;79(3):853-866. Epub 2023 May 8 doi: 10.1016/j.jhep.2023.04.033. PMID: 37164270Free PMC Article
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241

Recent clinical studies

Etiology

Li X, Tang J, Mao Y
Liver Int 2022 Aug;42(9):1999-2014. Epub 2022 Apr 2 doi: 10.1111/liv.15262. PMID: 35353431
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Diagnosis

Tan CK, Ho D, Wang LM, Kumar R
World J Gastroenterol 2022 Jun 28;28(24):2654-2666. doi: 10.3748/wjg.v28.i24.2654. PMID: 35979160Free PMC Article
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Therapy

Zhang CJ, Meyer SR, O'Meara MJ, Huang S, Capeling MM, Ferrer-Torres D, Childs CJ, Spence JR, Fontana RJ, Sexton JZ
J Hepatol 2023 May;78(5):998-1006. Epub 2023 Feb 3 doi: 10.1016/j.jhep.2023.01.019. PMID: 36738840Free PMC Article
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R
Phytother Res 2018 Nov;32(11):2202-2213. Epub 2018 Aug 6 doi: 10.1002/ptr.6171. PMID: 30080294
Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y
Int J Mol Sci 2015 Nov 2;16(11):26087-124. doi: 10.3390/ijms161125942. PMID: 26540040Free PMC Article
Floyd J, Mirza I, Sachs B, Perry MC
Semin Oncol 2006 Feb;33(1):50-67. doi: 10.1053/j.seminoncol.2005.11.002. PMID: 16473644

Prognosis

Li X, Tang J, Mao Y
Liver Int 2022 Aug;42(9):1999-2014. Epub 2022 Apr 2 doi: 10.1111/liv.15262. PMID: 35353431
Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, Philips CA, George J, Jafri W, Sarin SK; Asia Pacific Association of Study of Liver
Hepatol Int 2021 Apr;15(2):258-282. Epub 2021 Feb 27 doi: 10.1007/s12072-021-10144-3. PMID: 33641080
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R
J Gastroenterol Hepatol 2008 Feb;23(2):192-202. Epub 2007 Nov 6 doi: 10.1111/j.1440-1746.2007.05207.x. PMID: 17995946

Clinical prediction guides

Zhang CJ, Meyer SR, O'Meara MJ, Huang S, Capeling MM, Ferrer-Torres D, Childs CJ, Spence JR, Fontana RJ, Sexton JZ
J Hepatol 2023 May;78(5):998-1006. Epub 2023 Feb 3 doi: 10.1016/j.jhep.2023.01.019. PMID: 36738840Free PMC Article
McAtee C
Crit Care Nurs Clin North Am 2022 Sep;34(3):267-275. Epub 2022 Jul 20 doi: 10.1016/j.cnc.2022.04.007. PMID: 36049846
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
Danan G, Teschke R
Int J Mol Sci 2015 Dec 24;17(1) doi: 10.3390/ijms17010014. PMID: 26712744Free PMC Article

Recent systematic reviews

Takesue Y, Hanai Y, Oda K, Hamada Y, Ueda T, Mayumi T, Matsumoto K, Fujii S, Takahashi Y, Miyazaki Y, Kimura T; Japanese Antimicrobial Therapeutic Drug Monitoring Guideline Committee
Clin Ther 2022 Dec;44(12):1604-1623. Epub 2022 Nov 22 doi: 10.1016/j.clinthera.2022.10.005. PMID: 36424314
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Yebyo HG, Aschmann HE, Kaufmann M, Puhan MA
Am Heart J 2019 Apr;210:18-28. Epub 2019 Jan 10 doi: 10.1016/j.ahj.2018.12.007. PMID: 30716508
Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA; PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):133-139. Epub 2017 Sep 1 doi: 10.1016/j.reuma.2017.07.020. PMID: 28867467

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