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Retinol Deficiency

MedGen UID:
163634
•Concept ID:
C0856901
•
Disease or Syndrome

Professional guidelines

PubMed

Vitamin A status and associated factors in infants attending at Primary Health Care in Goiânia, Goiás, Brazil.
da Silva LL, Peixoto Mdo R, Hadler MC, da Silva SA, Cobayashi F, Cardoso MA
Rev Bras Epidemiol 2015 Apr-Jun;18(2):490-502. doi: 10.1590/1980-5497201500020016. PMID: 26083518

Recent clinical studies

Etiology

Gestational Serum Retinol Deficiency Is Associated with Enamel Hypoplasia.
Samuel SR, Lai CWM, Khan MM, Mathew MG, Kramer MS, Hsu CS
J Dent Res 2023 Dec;102(13):1417-1424. Epub 2023 Oct 29 doi: 10.1177/00220345231200788. PMID: 37899507
Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study.
Song J, Jiang ZG
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000124. PMID: 37058112Free PMC Article
Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency.
Tekgündüz KŞ, Dilek D, Kara M, Öztürk N, Tekgündüz SE
Turk J Med Sci 2022 Apr;52(2):294-302. Epub 2022 Apr 14 doi: 10.55730/1300-0144.5315. [Epub ahead of print] PMID: 36161610Free PMC Article
Serum retinol levels and neonatal outcomes in preterm infants.
Chen HJ, Hsu CH, Chiang BL
J Formos Med Assoc 2017 Aug;116(8):626-633. Epub 2017 May 23 doi: 10.1016/j.jfma.2017.04.019. PMID: 28549589
Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis.
Woestenenk JW, Broos N, Stellato RK, Arets HG, van der Ent CK, Houwen RH
Clin Nutr 2016 Jun;35(3):654-9. Epub 2015 Apr 23 doi: 10.1016/j.clnu.2015.04.010. PMID: 25975494

Diagnosis

Gestational Serum Retinol Deficiency Is Associated with Enamel Hypoplasia.
Samuel SR, Lai CWM, Khan MM, Mathew MG, Kramer MS, Hsu CS
J Dent Res 2023 Dec;102(13):1417-1424. Epub 2023 Oct 29 doi: 10.1177/00220345231200788. PMID: 37899507
Factors that affect placental retinol transfer in preterm infants and mothers with retinol deficiency.
Tekgündüz KŞ, Dilek D, Kara M, Öztürk N, Tekgündüz SE
Turk J Med Sci 2022 Apr;52(2):294-302. Epub 2022 Apr 14 doi: 10.55730/1300-0144.5315. [Epub ahead of print] PMID: 36161610Free PMC Article
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components.
Teske M, Melges AP, de Souza FI, Fonseca FL, Sarni RO
Rev Paul Pediatr 2014 Mar;32(1):50-4. doi: 10.1590/s0103-05822014000100009. PMID: 24676190Free PMC Article
Clinical and subclinical ophthalmic findings with retinol deficiency.
Newman NJ, Capone A, Leeper HF, O'Day DG, Mandell B, Lambert SR, Thoft RA
Ophthalmology 1994 Jun;101(6):1077-83. doi: 10.1016/s0161-6420(94)38029-8. PMID: 8008350
Impression cytology for detection of vitamin A deficiency.
Natadisastra G, Wittpenn JR, West KP Jr, Muhilal, Sommer A
Arch Ophthalmol 1987 Sep;105(9):1224-8. doi: 10.1001/archopht.1987.01060090082033. PMID: 3307720

Therapy

Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age.
Cheng X, Li D, Yang C, Chen B, Xu P, Zhang L
Cochrane Database Syst Rev 2024 May 13;5(5):CD015306. doi: 10.1002/14651858.CD015306.pub2. PMID: 38738639Free PMC Article
Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study.
Song J, Jiang ZG
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000124. PMID: 37058112Free PMC Article
Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis.
Woestenenk JW, Broos N, Stellato RK, Arets HG, van der Ent CK, Houwen RH
Clin Nutr 2016 Jun;35(3):654-9. Epub 2015 Apr 23 doi: 10.1016/j.clnu.2015.04.010. PMID: 25975494
Differentiation-inducing liposoluble vitamin deficiency may explain frequent secondary solid tumors after hematopoietic stem cell transplantation: minireview.
Gedikoglu G, Altinoz MA
Neoplasma 2008;55(1):1-9. PMID: 18190234
Impression cytology for detection of vitamin A deficiency.
Natadisastra G, Wittpenn JR, West KP Jr, Muhilal, Sommer A
Arch Ophthalmol 1987 Sep;105(9):1224-8. doi: 10.1001/archopht.1987.01060090082033. PMID: 3307720

Prognosis

Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study.
Song J, Jiang ZG
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000124. PMID: 37058112Free PMC Article
Dynamics of Serum Retinol and Alpha-Tocopherol Levels According to Non-Alcoholic Fatty Liver Disease Status.
Jeon D, Son M, Shim J
Nutrients 2021 May 19;13(5) doi: 10.3390/nu13051720. PMID: 34069568Free PMC Article
Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis.
Woestenenk JW, Broos N, Stellato RK, Arets HG, van der Ent CK, Houwen RH
Clin Nutr 2016 Jun;35(3):654-9. Epub 2015 Apr 23 doi: 10.1016/j.clnu.2015.04.010. PMID: 25975494
Plasma concentrations of retinol in obese children and adolescents: relationship to metabolic syndrome components.
Teske M, Melges AP, de Souza FI, Fonseca FL, Sarni RO
Rev Paul Pediatr 2014 Mar;32(1):50-4. doi: 10.1590/s0103-05822014000100009. PMID: 24676190Free PMC Article
Serum retinol and xerophthalmia among a prison population in Papua New Guinea.
Brian G, Tousignant B, Venn BJ, McKay R, Gould C
Ophthalmic Epidemiol 2011 Dec;18(6):288-94. doi: 10.3109/09286586.2011.615450. PMID: 22053839

Clinical prediction guides

Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study.
Song J, Jiang ZG
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 14 doi: 10.1097/HC9.0000000000000124. PMID: 37058112Free PMC Article
Dynamics of Serum Retinol and Alpha-Tocopherol Levels According to Non-Alcoholic Fatty Liver Disease Status.
Jeon D, Son M, Shim J
Nutrients 2021 May 19;13(5) doi: 10.3390/nu13051720. PMID: 34069568Free PMC Article
Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis.
Woestenenk JW, Broos N, Stellato RK, Arets HG, van der Ent CK, Houwen RH
Clin Nutr 2016 Jun;35(3):654-9. Epub 2015 Apr 23 doi: 10.1016/j.clnu.2015.04.010. PMID: 25975494
Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years.
Saraiva BC, Soares MC, Santos LC, Pereira SC, Horta PM
J Pediatr (Rio J) 2014 Nov-Dec;90(6):593-9. Epub 2014 Jun 20 doi: 10.1016/j.jped.2014.03.003. PMID: 24953720
Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome.
Battistini TR, Sarni RO, de Souza FI, Pitta TS, Fernandes AP, Hix S, Fonseca FL, Tardini PC, dos Santos VP, Lopez FA
Nutrition 2010 Jun;26(6):612-6. Epub 2010 Jan 29 doi: 10.1016/j.nut.2009.06.024. PMID: 20116215

Recent systematic reviews

Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age.
Cheng X, Li D, Yang C, Chen B, Xu P, Zhang L
Cochrane Database Syst Rev 2024 May 13;5(5):CD015306. doi: 10.1002/14651858.CD015306.pub2. PMID: 38738639Free PMC Article
Prevalence, determinants, intervention strategies and current gaps in addressing childhood malnutrition in Vietnam: a systematic review.
Mondon C, Tan PY, Chan CL, Tran TN, Gong YY
BMC Public Health 2024 Apr 4;24(1):960. doi: 10.1186/s12889-024-18419-8. PMID: 38575928Free PMC Article

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