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Abnormal platelet function

MedGen UID:
488944
•Concept ID:
C0855740
•
Finding
HPO: HP:0011869

Definition

Any anomaly in the function of thrombocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal platelet function

Professional guidelines

PubMed

An update on management of pediatric epistaxis.
Patel N, Maddalozzo J, Billings KR
Int J Pediatr Otorhinolaryngol 2014 Aug;78(8):1400-4. Epub 2014 Jun 16 doi: 10.1016/j.ijporl.2014.06.009. PMID: 24972938
Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management.
Furlan JC, Fehlings MG
Neurosurg Focus 2008;25(5):E13. doi: 10.3171/FOC.2008.25.11.E13. PMID: 18980473
Cardiac anesthesia risk management. Hemorrhage, coagulation, and transfusion: a risk-benefit analysis.
Spiess BD
J Cardiothorac Vasc Anesth 1994 Feb;8(1 Suppl 1):19-22. doi: 10.1016/1053-0770(94)90612-2. PMID: 8167299

Recent clinical studies

Therapy

Platelet activation in heart failure.
Schäfer A, Eigenthaler M, Bauersachs J
Clin Lab 2004;50(9-10):559-66. PMID: 15481631
Coronary artery disease and depression.
Zellweger MJ, Osterwalder RH, Langewitz W, Pfisterer ME
Eur Heart J 2004 Jan;25(1):3-9. doi: 10.1016/j.ehj.2003.09.009. PMID: 14683736
von Willebrand disease.
Zimmerman TS, Ruggeri ZM
Hum Pathol 1987 Feb;18(2):140-52. doi: 10.1016/s0046-8177(87)80332-5. PMID: 3100416
Sulfonylureas and platelet function.
Klaff LJ, Kernoff L, Vinik AI, Jackson WP, Jacobs P
Am J Med 1981 Mar;70(3):627-30. doi: 10.1016/0002-9343(81)90585-4. PMID: 6782875
Platelet function tests in disease.
Tschopp TB, Zucker MB
Annu Rev Med 1973;24:1-18. doi: 10.1146/annurev.me.24.020173.000245. PMID: 4575852

Prognosis

Bleeding phenotype and hemostatic evaluation by thrombin generation in children with Noonan syndrome: A prospective study.
Barg AA, Yeshayahu Y, Avishai E, Budnik I, Cohen O, Brutman-Barazani T, Dardik R, Raas-Rothschild A, Levy-Mendelovich S, Livnat T, Pinhas-Hamiel O, Kenet G
Pediatr Blood Cancer 2024 Feb;71(2):e30761. Epub 2023 Nov 16 doi: 10.1002/pbc.30761. PMID: 37974388
Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
Platelet Function Tests and Inflammatory Markers for the Differentiation of Primary Thrombocytosis and Secondary Thrombocytosis.
Kanya P, Rattarittamrong E, Wongtakan O, Rattanathammethee T, Chai-Adisaksopha C, Tantiworawit A, Norrasethada L
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2079-2085. doi: 10.31557/APJCP.2019.20.7.2079. PMID: 31350969Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
Impaired platelet function and peripartum bleeding in women with Gaucher disease.
Simchen MJ, Oz R, Shenkman B, Zimran A, Elstein D, Kenet G
Thromb Haemost 2011 Mar;105(3):509-14. Epub 2011 Feb 8 doi: 10.1160/TH10-07-0503. PMID: 21301776

Clinical prediction guides

Correlation of Platelet Function with Postpartum Hemorrhage and Venous Thromboembolism in Patients with Gestational Hypertension Complicated with Diabetes.
Li N, Liu Y, Yun A, Song S
Comput Math Methods Med 2022;2022:2423333. Epub 2022 Jul 18 doi: 10.1155/2022/2423333. PMID: 35898483Free PMC Article
RASopathies and hemostatic abnormalities: key role of platelet dysfunction.
Di Candia F, Marchetti V, Cirillo F, Di Minno A, Rosano C, Pagano S, Siano MA, Falco M, Assunto A, Boccia G, Magliacane G, Pinna V, De Luca A, Tartaglia M, Di Minno G, Strisciuglio P, Melis D
Orphanet J Rare Dis 2021 Dec 2;16(1):499. doi: 10.1186/s13023-021-02122-7. PMID: 34857025Free PMC Article
Hematological manifestations and complications of Gaucher disease.
Linari S, Castaman G
Expert Rev Hematol 2016 Jan;9(1):51-8. Epub 2015 Nov 13 doi: 10.1586/17474086.2016.1112732. PMID: 26565753
From genetics to epigenetics in platelet research.
Freson K, Izzi B, Van Geet C
Thromb Res 2012 Mar;129(3):325-9. Epub 2011 Dec 20 doi: 10.1016/j.thromres.2011.11.050. PMID: 22192152
Platelet function tests in disease.
Tschopp TB, Zucker MB
Annu Rev Med 1973;24:1-18. doi: 10.1146/annurev.me.24.020173.000245. PMID: 4575852

Recent systematic reviews

Screening for Platelet Dysfunction and Use of Prophylactic Tranexamic Acid in Patients Undergoing Deep Brain Stimulation: A Retrospective Analysis of Incidence and Outcome of Intracranial Hemorrhage.
Helmers AK, Kubelt C, Birkenfeld F, Deuschl G, Falk D, Mehdorn HM, Witt K, Nowak-Göttl U, Synowitz M, Paschen S
Stereotact Funct Neurosurg 2020;98(3):176-181. Epub 2020 Mar 30 doi: 10.1159/000505714. PMID: 32224614

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