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Low renin

MedGen UID:
167790
•Concept ID:
C0855389
•
Finding
Synonym: Decreased renin

Professional guidelines

PubMed

Diagnosis and Treatment of Monogenic Hypertension in Children.
Park SJ, Shin JI
Yonsei Med J 2023 Feb;64(2):77-86. doi: 10.3349/ymj.2022.0316. PMID: 36719014Free PMC Article
Primary aldosteronism in the primary care setting.
Buffolo F, Monticone S, Tetti M, Mulatero P
Curr Opin Endocrinol Diabetes Obes 2018 Jun;25(3):155-159. doi: 10.1097/MED.0000000000000408. PMID: 29629943
Diagnosis and treatment of low-renin hypertension.
Mulatero P, Verhovez A, Morello F, Veglio F
Clin Endocrinol (Oxf) 2007 Sep;67(3):324-34. Epub 2007 Jun 15 doi: 10.1111/j.1365-2265.2007.02898.x. PMID: 17573898

Recent clinical studies

Etiology

Monogenic Etiology of Hypertension.
Singh V, Van Why SK
Med Clin North Am 2024 Jan;108(1):157-172. Epub 2023 Jul 27 doi: 10.1016/j.mcna.2023.06.005. PMID: 37951648
18-Oxocortisol: A journey.
Gomez-Sanchez CE, Gomez-Sanchez EP
J Steroid Biochem Mol Biol 2023 Jun;230:106291. Epub 2023 Mar 13 doi: 10.1016/j.jsbmb.2023.106291. PMID: 36921907Free PMC Article
The spectrum of low-renin hypertension.
Buffolo F, Monticone S, Pecori A, Pieroni J, Losano I, Cavaglià G, Tetti M, Veglio F, Mulatero P
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101399. Epub 2020 Feb 25 doi: 10.1016/j.beem.2020.101399. PMID: 32147420
Controlling resistant hypertension.
Spence JD
Stroke Vasc Neurol 2018 Jun;3(2):69-75. Epub 2018 Feb 24 doi: 10.1136/svn-2017-000138. PMID: 30022799Free PMC Article
Thiazide and loop diuretics.
Sica DA, Carter B, Cushman W, Hamm L
J Clin Hypertens (Greenwich) 2011 Sep;13(9):639-43. Epub 2011 Jul 27 doi: 10.1111/j.1751-7176.2011.00512.x. PMID: 21896142Free PMC Article

Diagnosis

Monogenic Etiology of Hypertension.
Singh V, Van Why SK
Med Clin North Am 2024 Jan;108(1):157-172. Epub 2023 Jul 27 doi: 10.1016/j.mcna.2023.06.005. PMID: 37951648
Low-Renin Hypertension.
Athimulam S, Lazik N, Bancos I
Endocrinol Metab Clin North Am 2019 Dec;48(4):701-715. Epub 2019 Sep 25 doi: 10.1016/j.ecl.2019.08.003. PMID: 31655771
Aldosterone-Producing Adenomas.
Hellman P, Björklund P, Åkerström T
Vitam Horm 2019;109:407-431. Epub 2019 Jan 8 doi: 10.1016/bs.vh.2018.10.007. PMID: 30678866
Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.
Manosroi W, Williams GH
Endocr Rev 2019 Jun 1;40(3):825-856. doi: 10.1210/er.2018-00071. PMID: 30590482Free PMC Article
Controlling resistant hypertension.
Spence JD
Stroke Vasc Neurol 2018 Jun;3(2):69-75. Epub 2018 Feb 24 doi: 10.1136/svn-2017-000138. PMID: 30022799Free PMC Article

Therapy

Low-Renin Hypertension.
Athimulam S, Lazik N, Bancos I
Endocrinol Metab Clin North Am 2019 Dec;48(4):701-715. Epub 2019 Sep 25 doi: 10.1016/j.ecl.2019.08.003. PMID: 31655771
Controlling resistant hypertension.
Spence JD
Stroke Vasc Neurol 2018 Jun;3(2):69-75. Epub 2018 Feb 24 doi: 10.1136/svn-2017-000138. PMID: 30022799Free PMC Article
Posaconazole-Induced Pseudohyperaldosteronism.
Kuriakose K, Nesbitt WJ, Greene M, Harris B
Antimicrob Agents Chemother 2018 May;62(5) Epub 2018 Apr 26 doi: 10.1128/AAC.02130-17. PMID: 29530850Free PMC Article
Thiazide and loop diuretics.
Sica DA, Carter B, Cushman W, Hamm L
J Clin Hypertens (Greenwich) 2011 Sep;13(9):639-43. Epub 2011 Jul 27 doi: 10.1111/j.1751-7176.2011.00512.x. PMID: 21896142Free PMC Article
Hypertension in blacks.
Saunders E
Prim Care 1991 Sep;18(3):607-22. PMID: 1946790

Prognosis

18-Oxocortisol: A journey.
Gomez-Sanchez CE, Gomez-Sanchez EP
J Steroid Biochem Mol Biol 2023 Jun;230:106291. Epub 2023 Mar 13 doi: 10.1016/j.jsbmb.2023.106291. PMID: 36921907Free PMC Article
Monogenic forms of low-renin hypertension: clinical and molecular insights.
Khandelwal P, Deinum J
Pediatr Nephrol 2022 Jul;37(7):1495-1509. Epub 2021 Aug 20 doi: 10.1007/s00467-021-05246-x. PMID: 34414500
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome.
Carvajal CA, Tapia-Castillo A, Vecchiola A, Baudrand R, Fardella CE
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz315. PMID: 31909799
Cerebrovascular consequences of pseudohyperaldosteronism.
Smith JH, Lindor NM, Rabinstein AA
J Clin Hypertens (Greenwich) 2012 Aug;14(8):547-52. Epub 2012 May 3 doi: 10.1111/j.1751-7176.2012.00639.x. PMID: 22863163Free PMC Article
Low renin hypertension.
Gunnells JC Jr, McGuffin WL Jr
Annu Rev Med 1975;26:259-75. doi: 10.1146/annurev.me.26.020175.001355. PMID: 1096763

Clinical prediction guides

Sex-specific association of low-renin hypertension with metabolic and musculoskeletal health in Korean older adults.
Lee S, Chang JS, Park KS, Koh SB, Kim MY, Lim JS
Front Public Health 2024;12:1250945. Epub 2024 Feb 12 doi: 10.3389/fpubh.2024.1250945. PMID: 38410670Free PMC Article
18-Oxocortisol: A journey.
Gomez-Sanchez CE, Gomez-Sanchez EP
J Steroid Biochem Mol Biol 2023 Jun;230:106291. Epub 2023 Mar 13 doi: 10.1016/j.jsbmb.2023.106291. PMID: 36921907Free PMC Article
Clinical and genetic characteristics of the patients with hypertension and hypokalemia carrying a novel SCNN1A mutation.
Chen M, Lv X, Li J, Guo M, Ma S
Scand J Clin Lab Invest 2022 Nov-Dec;82(7-8):576-580. Epub 2022 Nov 6 doi: 10.1080/00365513.2022.2140454. PMID: 36336351
SFE/SFHTA/AFCE Consensus on Primary Aldosteronism, part 2: First diagnostic steps.
Douillard C, Houillier P, Nussberger J, Girerd X
Ann Endocrinol (Paris) 2016 Jul;77(3):192-201. Epub 2016 May 10 doi: 10.1016/j.ando.2016.02.003. PMID: 27177498
Cerebrovascular consequences of pseudohyperaldosteronism.
Smith JH, Lindor NM, Rabinstein AA
J Clin Hypertens (Greenwich) 2012 Aug;14(8):547-52. Epub 2012 May 3 doi: 10.1111/j.1751-7176.2012.00639.x. PMID: 22863163Free PMC Article

Recent systematic reviews

Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis.
Shah SS, Zhang J, Gwini SM, Young MJ, Fuller PJ, Yang J
J Hum Hypertens 2024 May;38(5):383-392. Epub 2024 Jan 11 doi: 10.1038/s41371-023-00891-1. PMID: 38200100Free PMC Article
Apparent Mineralocorticoid Excess in the Pediatric Population: Report of a Novel Pathogenic Variant of the 11β-HSD2 Gene and Systematic Review of the Literature.
Adamidis A, Cantas-Orsdemir S, Tsirka A, Abbott MA, Visintainer P, Tonyushkina K
Pediatr Endocrinol Rev 2019 Mar;16(3):335-358. doi: 10.17458/per.vol16.2019.act.mineralocorticoid. PMID: 30888125

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