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Resectable Malignant Liver Neoplasm

MedGen UID:
163148
•Concept ID:
C0854795
•
Neoplastic Process
Synonyms: Resectable Hepatic Malignant Neoplasm; Resectable Malignant Neoplasm of Liver

Definition

A malignant liver neoplasm that is amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines.
Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, Muiesan P, Mirza DF, Isaac J, Laing RW, Iyer SG, Chee CE, Yong WP, Muthiah MD, Panaro F, Sanabria J, Grothey A, Moodley K, Chau I, Chan ACY, Wang CC, Menon K, Sapisochin G, Hagness M, Dueland S, Line PD, Adam R
Lancet Gastroenterol Hepatol 2021 Nov;6(11):933-946. Epub 2021 Sep 8 doi: 10.1016/S2468-1253(21)00219-3. PMID: 34506756
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Recent clinical studies

Etiology

Pediatric hepatocellular carcinoma.
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
HEPATOCELLULAR CARCINOMA: DIAGNOSIS AND OPERATIVE MANAGEMENT.
Chedid MF, Kruel CRP, Pinto MA, Grezzana-Filho TJM, Leipnitz I, Kruel CDP, Scaffaro LA, Chedid AD
Arq Bras Cir Dig 2017 Oct-Dec;30(4):272-278. doi: 10.1590/0102-6720201700040011. PMID: 29340553Free PMC Article
When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations.
Lesurtel M, Nagorney DM, Mazzaferro V, Jensen RT, Poston GJ
HPB (Oxford) 2015 Jan;17(1):17-22. Epub 2014 Mar 17 doi: 10.1111/hpb.12225. PMID: 24636662Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262
Transplantation for cholangiocarcinoma.
Masuoka HC, Rosen CB
Clin Liver Dis 2011 Nov;15(4):699-715. doi: 10.1016/j.cld.2011.08.004. PMID: 22032524

Diagnosis

Pediatric Hepatocellular Carcinoma.
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Cancers Metastatic to the Liver.
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Role of Hepatic Artery Infusion Chemotherapy in Treatment of Initially Unresectable Colorectal Liver Metastases: A Review.
Datta J, Narayan RR, Kemeny NE, D'Angelica MI
JAMA Surg 2019 Aug 1;154(8):768-776. doi: 10.1001/jamasurg.2019.1694. PMID: 31188415
Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Therapy

Pediatric Hepatocellular Carcinoma.
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation.
Hack SP, Spahn J, Chen M, Cheng AL, Kaseb A, Kudo M, Lee HC, Yopp A, Chow P, Qin S
Future Oncol 2020 May;16(15):975-989. Epub 2020 Apr 30 doi: 10.2217/fon-2020-0162. PMID: 32352320
Pediatric hepatocellular carcinoma.
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations.
Lesurtel M, Nagorney DM, Mazzaferro V, Jensen RT, Poston GJ
HPB (Oxford) 2015 Jan;17(1):17-22. Epub 2014 Mar 17 doi: 10.1111/hpb.12225. PMID: 24636662Free PMC Article
Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.
Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, Bechstein WO, Primrose JN, Walpole ET, Finch-Jones M, Jaeck D, Mirza D, Parks RW, Mauer M, Tanis E, Van Cutsem E, Scheithauer W, Gruenberger T; EORTC Gastro-Intestinal Tract Cancer Group; Cancer Research UK; Arbeitsgruppe Lebermetastasen und–tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG); Fédération Francophone de Cancérologie Digestive (FFCD)
Lancet Oncol 2013 Nov;14(12):1208-15. Epub 2013 Oct 11 doi: 10.1016/S1470-2045(13)70447-9. PMID: 24120480

Prognosis

Pediatric Hepatocellular Carcinoma.
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Cancers Metastatic to the Liver.
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Current Treatment of Colorectal Liver Metastasis as a Chronic Disease.
Dörr NM, Bartels M, Morgul MH
Anticancer Res 2020 Jan;40(1):1-7. doi: 10.21873/anticanres.13921. PMID: 31892548
Hepatitis B and Hepatocellular Carcinoma.
Hemming AW, Berumen J, Mekeel K
Clin Liver Dis 2016 Nov;20(4):703-720. Epub 2016 Aug 9 doi: 10.1016/j.cld.2016.06.007. PMID: 27742009
Hepatoblastoma of the adult: A systematic review of the literature.
Celotti A, D'Amico G, Ceresoli M, Tomasoni M, Raimondo S, Baggi P, Baiocchi GL
Surg Oncol 2016 Sep;25(3):339-47. Epub 2016 Jul 20 doi: 10.1016/j.suronc.2016.07.003. PMID: 27566042

Clinical prediction guides

Resection Postradioembolization in Patients With Single Large Hepatocellular Carcinoma.
Tzedakis S, Sebai A, Jeddou H, Garin E, Rolland Y, Bourien H, Uguen T, Sulpice L, Robin F, Edeline J, Boudjema K
Ann Surg 2023 Nov 1;278(5):756-762. Epub 2023 Aug 4 doi: 10.1097/SLA.0000000000006061. PMID: 37539588
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Multidisciplinary treatment of colorectal liver metastases.
Schiergens TS, von Einem J, Thomas MN, Albertsmeier M, Giessen-Jung C, Dörsch M, Heiliger C, Drefs M, Andrassy J, Modest DP, Stintzing S, Guba M, Angele M, Werner J, Rentsch M
Minerva Med 2017 Dec;108(6):527-546. Epub 2017 Sep 8 doi: 10.23736/S0026-4806.17.05371-X. PMID: 28889727
The difficulty of laparoscopic liver resection.
Ban D, Kudo A, Ito H, Mitsunori Y, Matsumura S, Aihara A, Ochiai T, Tanaka S, Tanabe M, Itano O, Kaneko H, Wakabayashi G
Updates Surg 2015 Jun;67(2):123-8. Epub 2015 Jul 10 doi: 10.1007/s13304-015-0302-7. PMID: 26160064
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Management of neuroendocrine tumor liver metastases.
Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
A Comprehensive Review of Hepatic Hemangioma Management.
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline.
Apisarnthanarax S, Barry A, Cao M, Czito B, DeMatteo R, Drinane M, Hallemeier CL, Koay EJ, Lasley F, Meyer J, Owen D, Pursley J, Schaub SK, Smith G, Venepalli NK, Zibari G, Cardenes H
Pract Radiat Oncol 2022 Jan-Feb;12(1):28-51. Epub 2021 Oct 21 doi: 10.1016/j.prro.2021.09.004. PMID: 34688956
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations.
Lesurtel M, Nagorney DM, Mazzaferro V, Jensen RT, Poston GJ
HPB (Oxford) 2015 Jan;17(1):17-22. Epub 2014 Mar 17 doi: 10.1111/hpb.12225. PMID: 24636662Free PMC Article

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