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Necrotizing fasciitis caused by Streptococcus pyogenes

MedGen UID:
678517
•Concept ID:
C0854084
•
Disease or Syndrome
Synonyms: Streptococcal gangrene; Streptococcal necrotizing fasciitis; Type II necrotizing fasciitis
SNOMED CT: Streptococcal gangrene (449900006); Type II necrotizing fasciitis (449900006); Streptococcal necrotizing fasciitis (449900006); Necrotizing fasciitis caused by Streptococcus pyogenes (449900006)

Professional guidelines

PubMed

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.
Allaw F, Wehbe S, Kanj SS
Curr Opin Infect Dis 2024 Apr 1;37(2):105-111. Epub 2023 Nov 30 doi: 10.1097/QCO.0000000000000988. PMID: 38037890
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature.
Zundel S, Lemaréchal A, Kaiser P, Szavay P
Eur J Pediatr Surg 2017 Apr;27(2):127-137. Epub 2016 Jul 5 doi: 10.1055/s-0036-1584531. PMID: 27380058
Necrotizing fasciitis: pathogenesis and treatment.
Young MH, Aronoff DM, Engleberg NC
Expert Rev Anti Infect Ther 2005 Apr;3(2):279-94. doi: 10.1586/14787210.3.2.279. PMID: 15918785

Recent clinical studies

Etiology

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.
Allaw F, Wehbe S, Kanj SS
Curr Opin Infect Dis 2024 Apr 1;37(2):105-111. Epub 2023 Nov 30 doi: 10.1097/QCO.0000000000000988. PMID: 38037890
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study.
Bruun T, Rath E, Madsen MB, Oppegaard O, Nekludov M, Arnell P, Karlsson Y, Babbar A, Bergey F, Itzek A, Hyldegaard O, Norrby-Teglund A, Skrede S; INFECT Study Group
Clin Infect Dis 2021 Jan 27;72(2):293-300. doi: 10.1093/cid/ciaa027. PMID: 31923305Free PMC Article
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Necrotizing fasciitis.
Jamal N, Teach SJ
Pediatr Emerg Care 2011 Dec;27(12):1195-9; quiz 1200-2. doi: 10.1097/PEC.0b013e31823b583c. PMID: 22158285
Necrotizing fasciitis.
Cherneski CL, Embil JM
Saudi Med J 2001 Jul;22(7):565-8. PMID: 11479634

Diagnosis

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.
Allaw F, Wehbe S, Kanj SS
Curr Opin Infect Dis 2024 Apr 1;37(2):105-111. Epub 2023 Nov 30 doi: 10.1097/QCO.0000000000000988. PMID: 38037890
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature.
Zundel S, Lemaréchal A, Kaiser P, Szavay P
Eur J Pediatr Surg 2017 Apr;27(2):127-137. Epub 2016 Jul 5 doi: 10.1055/s-0036-1584531. PMID: 27380058
Necrotizing fasciitis.
Jamal N, Teach SJ
Pediatr Emerg Care 2011 Dec;27(12):1195-9; quiz 1200-2. doi: 10.1097/PEC.0b013e31823b583c. PMID: 22158285
Necrotizing fasciitis.
Cherneski CL, Embil JM
Saudi Med J 2001 Jul;22(7):565-8. PMID: 11479634

Therapy

Necrotizing fasciitis: an update on epidemiology, diagnostic methods, and treatment.
Allaw F, Wehbe S, Kanj SS
Curr Opin Infect Dis 2024 Apr 1;37(2):105-111. Epub 2023 Nov 30 doi: 10.1097/QCO.0000000000000988. PMID: 38037890
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Necrotizing fasciitis.
Jamal N, Teach SJ
Pediatr Emerg Care 2011 Dec;27(12):1195-9; quiz 1200-2. doi: 10.1097/PEC.0b013e31823b583c. PMID: 22158285
Necrotizing fasciitis: pathogenesis and treatment.
Young MH, Aronoff DM, Engleberg NC
Expert Rev Anti Infect Ther 2005 Apr;3(2):279-94. doi: 10.1586/14787210.3.2.279. PMID: 15918785
Necrotizing fasciitis.
Cherneski CL, Embil JM
Saudi Med J 2001 Jul;22(7):565-8. PMID: 11479634

Prognosis

Incidence and mortality of necrotizing fasciitis in The Netherlands: the impact of group A Streptococcus.
Nawijn F, de Gier B, Brandwagt DAH, Groenwold RHH, Keizer J, Hietbrink F
BMC Infect Dis 2021 Dec 6;21(1):1217. doi: 10.1186/s12879-021-06928-5. PMID: 34872527Free PMC Article
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study.
Bruun T, Rath E, Madsen MB, Oppegaard O, Nekludov M, Arnell P, Karlsson Y, Babbar A, Bergey F, Itzek A, Hyldegaard O, Norrby-Teglund A, Skrede S; INFECT Study Group
Clin Infect Dis 2021 Jan 27;72(2):293-300. doi: 10.1093/cid/ciaa027. PMID: 31923305Free PMC Article
Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections.
Bruun T, Rath E, Oppegaard O, Skrede S
Adv Exp Med Biol 2020;1294:73-86. doi: 10.1007/978-3-030-57616-5_6. PMID: 33079364
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Necrotizing fasciitis: pathogenesis and treatment.
Young MH, Aronoff DM, Engleberg NC
Expert Rev Anti Infect Ther 2005 Apr;3(2):279-94. doi: 10.1586/14787210.3.2.279. PMID: 15918785

Clinical prediction guides

Increase in Streptococcal Necrotizing Fasciitis During and After the Coronavirus Disease 2019 Pandemic.
Breidung D, Billner M, Megas IF, Edo AM, Reichert B, Malsagova AT
Surg Infect (Larchmt) 2024 Mar;25(2):169-174. Epub 2024 Feb 6 doi: 10.1089/sur.2023.233. PMID: 38324002
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study.
Bruun T, Rath E, Madsen MB, Oppegaard O, Nekludov M, Arnell P, Karlsson Y, Babbar A, Bergey F, Itzek A, Hyldegaard O, Norrby-Teglund A, Skrede S; INFECT Study Group
Clin Infect Dis 2021 Jan 27;72(2):293-300. doi: 10.1093/cid/ciaa027. PMID: 31923305Free PMC Article
Beta-Hemolytic Streptococci and Necrotizing Soft Tissue Infections.
Bruun T, Rath E, Oppegaard O, Skrede S
Adv Exp Med Biol 2020;1294:73-86. doi: 10.1007/978-3-030-57616-5_6. PMID: 33079364
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Necrotizing fasciitis and myositis caused by group A streptococci. Epidemiology, diagnosis, and treatment of "flesh-eating bacteria".
Abolnik IZ, Sexton DJ
N C Med J 1994 Oct;55(10):464-6. PMID: 7800056

Recent systematic reviews

Invasive group A streptococcal disease in pregnant women and young children: a systematic review and meta-analysis.
Sherwood E, Vergnano S, Kakuchi I, Bruce MG, Chaurasia S, David S, Dramowski A, Georges S, Guy R, Lamagni T, Levy-Bruhl D, Lyytikäinen O, Naus M, Okaro JO, Oppegaard O, Vestrheim DF, Zulz T, Steer AC, Van Beneden CA, Seale AC
Lancet Infect Dis 2022 Jul;22(7):1076-1088. Epub 2022 Apr 4 doi: 10.1016/S1473-3099(21)00672-1. PMID: 35390294Free PMC Article
Necrotizing Soft Tissue Infections: A Focused Review of Pathophysiology, Diagnosis, Operative Management, Antimicrobial Therapy, and Pediatrics.
Tessier JM, Sanders J, Sartelli M, Ulrych J, De Simone B, Grabowski J, Buckman S, Duane TM
Surg Infect (Larchmt) 2020 Mar;21(2):81-93. Epub 2019 Oct 4 doi: 10.1089/sur.2019.219. PMID: 31584343
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature.
Zundel S, Lemaréchal A, Kaiser P, Szavay P
Eur J Pediatr Surg 2017 Apr;27(2):127-137. Epub 2016 Jul 5 doi: 10.1055/s-0036-1584531. PMID: 27380058

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