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Immune Hemolytic Anemia

MedGen UID:
452755
•Concept ID:
C0852336
•
Disease or Syndrome

Definition

An acquired anemia resulting from immune-mediated destruction of the red blood cells. Causes include autoimmune disorders, blood transfusions, and drugs. [from NCI]

Professional guidelines

PubMed

Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.
Loriamini M, Cserti-Gazdewich C, Branch DR
Int J Mol Sci 2024 Apr 12;25(8) doi: 10.3390/ijms25084296. PMID: 38673882Free PMC Article
Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study.
Maquet J, Lafaurie M, Michel M, Lapeyre-Mestre M, Moulis G
Blood Adv 2024 Feb 13;8(3):817-826. doi: 10.1182/bloodadvances.2023009801. PMID: 37782770Free PMC Article
Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan.
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M; For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants
Int J Hematol 2017 Jul;106(1):3-15. Epub 2017 May 26 doi: 10.1007/s12185-017-2264-7. PMID: 28550351

Recent clinical studies

Etiology

Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.
Loriamini M, Cserti-Gazdewich C, Branch DR
Int J Mol Sci 2024 Apr 12;25(8) doi: 10.3390/ijms25084296. PMID: 38673882Free PMC Article
Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study.
Maquet J, Lafaurie M, Michel M, Lapeyre-Mestre M, Moulis G
Blood Adv 2024 Feb 13;8(3):817-826. doi: 10.1182/bloodadvances.2023009801. PMID: 37782770Free PMC Article
A randomized and double-blind controlled trial evaluating the safety and efficacy of rituximab for warm auto-immune hemolytic anemia in adults (the RAIHA study).
Michel M, Terriou L, Roudot-Thoraval F, Hamidou M, Ebbo M, Le Guenno G, Galicier L, Audia S, Royer B, Morin AS, Marie Michot J, Jaccard A, Frenzel L, Khellaf M, Godeau B
Am J Hematol 2017 Jan;92(1):23-27. Epub 2016 Nov 10 doi: 10.1002/ajh.24570. PMID: 27696475
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184
Auto-immune hemolytic anemia.
Issitt PD
Am J Med Technol 1974 Nov;40(11):479-95. PMID: 4215323

Diagnosis

Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.
Loriamini M, Cserti-Gazdewich C, Branch DR
Int J Mol Sci 2024 Apr 12;25(8) doi: 10.3390/ijms25084296. PMID: 38673882Free PMC Article
Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study.
Maquet J, Lafaurie M, Michel M, Lapeyre-Mestre M, Moulis G
Blood Adv 2024 Feb 13;8(3):817-826. doi: 10.1182/bloodadvances.2023009801. PMID: 37782770Free PMC Article
DAT-Negative Autoimmune Hemolytic Anemia.
Rodberg K
Hematol Oncol Clin North Am 2022 Apr;36(2):307-313. Epub 2022 Mar 10 doi: 10.1016/j.hoc.2021.11.004. PMID: 35282952
Hereditary spherocytosis.
Iolascon A, Avvisati RA, Piscopo C
Transfus Clin Biol 2010 Sep;17(3):138-42. Epub 2010 Jul 23 doi: 10.1016/j.tracli.2010.05.006. PMID: 20655264
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184

Therapy

Drug-induced immune hemolytic anemia: detection of new signals and risk assessment in a nationwide cohort study.
Maquet J, Lafaurie M, Michel M, Lapeyre-Mestre M, Moulis G
Blood Adv 2024 Feb 13;8(3):817-826. doi: 10.1182/bloodadvances.2023009801. PMID: 37782770Free PMC Article
A randomized and double-blind controlled trial evaluating the safety and efficacy of rituximab for warm auto-immune hemolytic anemia in adults (the RAIHA study).
Michel M, Terriou L, Roudot-Thoraval F, Hamidou M, Ebbo M, Le Guenno G, Galicier L, Audia S, Royer B, Morin AS, Marie Michot J, Jaccard A, Frenzel L, Khellaf M, Godeau B
Am J Hematol 2017 Jan;92(1):23-27. Epub 2016 Nov 10 doi: 10.1002/ajh.24570. PMID: 27696475
Drug-induced immune hemolytic anemia.
Garratty G
Hematology Am Soc Hematol Educ Program 2009:73-9. doi: 10.1182/asheducation-2009.1.73. PMID: 20008184
Immune Hemolytic anemia.
Axelson JA, LoBuglio AF
Med Clin North Am 1980 Jul;64(4):597-606. doi: 10.1016/s0025-7125(16)31583-8. PMID: 6995725
Auto-immune hemolytic anemia.
Issitt PD
Am J Med Technol 1974 Nov;40(11):479-95. PMID: 4215323

Prognosis

Factors associated with immune hemolytic anemia after pediatric liver transplantation.
Rock N, Ansari M, Villard J, Ferrari-Lacraz S, Waldvogel S, McLin VA
Pediatr Transplant 2018 Aug;22(5):e13230. Epub 2018 Jun 8 doi: 10.1111/petr.13230. PMID: 29885007
Ceftriaxone-induced immune hemolytic anemia.
Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S
Ann Pharmacother 2014 Dec;48(12):1594-604. Epub 2014 Aug 27 doi: 10.1177/1060028014548310. PMID: 25163809
Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.
Segel GB, Lichtman MA
Blood Cells Mol Dis 2014 Apr;52(4):152-60. Epub 2014 Jan 9 doi: 10.1016/j.bcmd.2013.12.003. PMID: 24411920
Laboratory tests for paroxysmal nocturnal hemoglobinuria.
Preis M, Lowrey CH
Am J Hematol 2014 Mar;89(3):339-41. doi: 10.1002/ajh.23612. PMID: 24127129
Immune Hemolytic anemia.
Axelson JA, LoBuglio AF
Med Clin North Am 1980 Jul;64(4):597-606. doi: 10.1016/s0025-7125(16)31583-8. PMID: 6995725

Clinical prediction guides

Venous thromboembolism related to warm autoimmune hemolytic anemia: a case-control study.
Lecouffe-Desprets M, Néel A, Graveleau J, Leux C, Perrin F, Visomblain B, Artifoni M, Masseau A, Connault J, Pottier P, Agard C, Hamidou M
Autoimmun Rev 2015 Nov;14(11):1023-8. Epub 2015 Jul 8 doi: 10.1016/j.autrev.2015.07.001. PMID: 26162301
How we investigate drug-induced immune hemolytic anemia.
Leger RM, Arndt PA, Garratty G
Immunohematology 2014;30(2):85-94. PMID: 25247618
Ceftriaxone-induced immune hemolytic anemia.
Neuman G, Boodhan S, Wurman I, Koren G, Bitnun A, Kirby-Allen M, Ito S
Ann Pharmacother 2014 Dec;48(12):1594-604. Epub 2014 Aug 27 doi: 10.1177/1060028014548310. PMID: 25163809
Immune hemolytic anemia--selected topics.
Hoffman PC
Hematology Am Soc Hematol Educ Program 2009:80-6. doi: 10.1182/asheducation-2009.1.80. PMID: 20008185
Immune hemolytic anemia--selected topics.
Hoffman PC
Hematology Am Soc Hematol Educ Program 2006:13-8. doi: 10.1182/asheducation-2006.1.13. PMID: 17124033

Recent systematic reviews

Bendamustine-induced immune hemolytic anemia: a case report and systematic review of the literature.
Chan M, Silverstein WK, Nikonova A, Pavenski K, Hicks LK
Blood Adv 2020 Apr 28;4(8):1756-1759. doi: 10.1182/bloodadvances.2020001726. PMID: 32343794Free PMC Article

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