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Alcohol Related Neurodevelopmental Disorder

MedGen UID:
163385
•Concept ID:
C0814154
•
Disease or Syndrome
Synonyms: FAE (Fetal Alcohol Effects); FAEs (Fetal Alcohol Effects); Growth Retardation, Facial Abnormalities, and Central Nervous System Dysfunction

Definition

A cognitive and neurological disorder due to fetal intrauterine exposure to maternal alcohol consumption. Typically, this presents without facies or other growth abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcohol Related Neurodevelopmental Disorder

Professional guidelines

PubMed

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.
Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA
Pediatrics 2016 Aug;138(2) Epub 2016 Jul 27 doi: 10.1542/peds.2015-4256. PMID: 27464676Free PMC Article
Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure.
Chasnoff IJ, Wells AM, King L
Pediatrics 2015 Feb;135(2):264-70. Epub 2015 Jan 12 doi: 10.1542/peds.2014-2171. PMID: 25583914
Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management.
Paley B, O'Connor MJ
Dev Disabil Res Rev 2009;15(3):258-67. doi: 10.1002/ddrr.67. PMID: 19731383

Recent clinical studies

Etiology

Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.
Kable JA, Jones KL
Alcohol Res 2023;43(1):03. Epub 2023 May 25 doi: 10.35946/arcr.v43.1.03. PMID: 37260694Free PMC Article
A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist.
Klug MG, O'Connell AM, Palme A, Kobrinsky N, Burd L
Alcohol Clin Exp Res 2021 Apr;45(4):765-772. Epub 2021 Apr 3 doi: 10.1111/acer.14570. PMID: 33583035
Fetal alcohol spectrum disorder among pre-adopted and foster children.
Tenenbaum A, Mandel A, Dor T, Sapir A, Sapir-Bodnaro O, Hertz P, Wexler ID
BMC Pediatr 2020 Jun 3;20(1):275. doi: 10.1186/s12887-020-02164-z. PMID: 32493264Free PMC Article
Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes.
Coles CD, Kalberg W, Kable JA, Tabachnick B, May PA, Chambers CD
Alcohol Clin Exp Res 2020 Jun;44(6):1245-1260. Epub 2020 May 20 doi: 10.1111/acer.14325. PMID: 32173870Free PMC Article
Cortical morphology in children with alcohol-related neurodevelopmental disorder.
Rajaprakash M, Chakravarty MM, Lerch JP, Rovet J
Brain Behav 2014 Jan;4(1):41-50. Epub 2013 Nov 27 doi: 10.1002/brb3.191. PMID: 24653953Free PMC Article

Diagnosis

Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.
Kable JA, Jones KL
Alcohol Res 2023;43(1):03. Epub 2023 May 25 doi: 10.35946/arcr.v43.1.03. PMID: 37260694Free PMC Article
A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist.
Klug MG, O'Connell AM, Palme A, Kobrinsky N, Burd L
Alcohol Clin Exp Res 2021 Apr;45(4):765-772. Epub 2021 Apr 3 doi: 10.1111/acer.14570. PMID: 33583035
Fetal alcohol spectrum disorder among pre-adopted and foster children.
Tenenbaum A, Mandel A, Dor T, Sapir A, Sapir-Bodnaro O, Hertz P, Wexler ID
BMC Pediatr 2020 Jun 3;20(1):275. doi: 10.1186/s12887-020-02164-z. PMID: 32493264Free PMC Article
Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes.
Coles CD, Kalberg W, Kable JA, Tabachnick B, May PA, Chambers CD
Alcohol Clin Exp Res 2020 Jun;44(6):1245-1260. Epub 2020 May 20 doi: 10.1111/acer.14325. PMID: 32173870Free PMC Article
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.
Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA
Pediatrics 2016 Aug;138(2) Epub 2016 Jul 27 doi: 10.1542/peds.2015-4256. PMID: 27464676Free PMC Article

Therapy

Fetal alcohol spectrum disorder among pre-adopted and foster children.
Tenenbaum A, Mandel A, Dor T, Sapir A, Sapir-Bodnaro O, Hertz P, Wexler ID
BMC Pediatr 2020 Jun 3;20(1):275. doi: 10.1186/s12887-020-02164-z. PMID: 32493264Free PMC Article
Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure.
Comasco E, Rangmar J, Eriksson UJ, Oreland L
Acta Physiol (Oxf) 2018 Jan;222(1) Epub 2017 May 30 doi: 10.1111/apha.12892. PMID: 28470828
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.
Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA
Pediatrics 2016 Aug;138(2) Epub 2016 Jul 27 doi: 10.1542/peds.2015-4256. PMID: 27464676Free PMC Article
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen S, Peters GJ, Kok G, Townend D, Nijhuis J, Curfs L
Alcohol Clin Exp Res 2016 Jan;40(1):18-32. doi: 10.1111/acer.12939. PMID: 26727519
Fetal alcohol spectrum disorder.
Nayak RB, Murthy P
Indian Pediatr 2008 Dec;45(12):977-83. PMID: 19129565

Prognosis

Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.
Kable JA, Jones KL
Alcohol Res 2023;43(1):03. Epub 2023 May 25 doi: 10.35946/arcr.v43.1.03. PMID: 37260694Free PMC Article
Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period.
Kable JA, Coles CD, Jones KL, Yevtushok L, Kulikovsky Y, Zymak-Zakutnya N, Dubchak I, Akhmedzhanova D, Wertelecki W, Chambers CD; CIFASD
Alcohol Clin Exp Res 2021 Feb;45(2):386-394. Epub 2021 Jan 6 doi: 10.1111/acer.14525. PMID: 33277942Free PMC Article
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen S, Peters GJ, Kok G, Townend D, Nijhuis J, Curfs L
Alcohol Clin Exp Res 2016 Jan;40(1):18-32. doi: 10.1111/acer.12939. PMID: 26727519
Prevalence and characteristics of fetal alcohol spectrum disorders.
May PA, Baete A, Russo J, Elliott AJ, Blankenship J, Kalberg WO, Buckley D, Brooks M, Hasken J, Abdul-Rahman O, Adam MP, Robinson LK, Manning M, Hoyme HE
Pediatrics 2014 Nov;134(5):855-66. doi: 10.1542/peds.2013-3319. PMID: 25349310Free PMC Article
Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder.
Sampson PD, Streissguth AP, Bookstein FL, Little RE, Clarren SK, Dehaene P, Hanson JW, Graham JM Jr
Teratology 1997 Nov;56(5):317-26. doi: 10.1002/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U. PMID: 9451756

Clinical prediction guides

Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.
Kable JA, Jones KL
Alcohol Res 2023;43(1):03. Epub 2023 May 25 doi: 10.35946/arcr.v43.1.03. PMID: 37260694Free PMC Article
A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist.
Klug MG, O'Connell AM, Palme A, Kobrinsky N, Burd L
Alcohol Clin Exp Res 2021 Apr;45(4):765-772. Epub 2021 Apr 3 doi: 10.1111/acer.14570. PMID: 33583035
Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.
Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Jewett T, Coles CD, Chambers C, Jones KL, Adnams CM, Shah PE, Riley EP, Charness ME, Warren KR, May PA
Pediatrics 2016 Aug;138(2) Epub 2016 Jul 27 doi: 10.1542/peds.2015-4256. PMID: 27464676Free PMC Article
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen S, Peters GJ, Kok G, Townend D, Nijhuis J, Curfs L
Alcohol Clin Exp Res 2016 Jan;40(1):18-32. doi: 10.1111/acer.12939. PMID: 26727519
Cortical morphology in children with alcohol-related neurodevelopmental disorder.
Rajaprakash M, Chakravarty MM, Lerch JP, Rovet J
Brain Behav 2014 Jan;4(1):41-50. Epub 2013 Nov 27 doi: 10.1002/brb3.191. PMID: 24653953Free PMC Article

Recent systematic reviews

What we know of the central auditory disorders in children exposed to alcohol during pregnancy? Systematic review.
Simões HO, Zanchetta S, Furtado EF
Codas 2016 9-10;28(5):640-645. doi: 10.1590/2317-1782/20162015253. PMID: 27849248
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen S, Peters GJ, Kok G, Townend D, Nijhuis J, Curfs L
Alcohol Clin Exp Res 2016 Jan;40(1):18-32. doi: 10.1111/acer.12939. PMID: 26727519
Gross motor deficits in children prenatally exposed to alcohol: a meta-analysis.
Lucas BR, Latimer J, Pinto RZ, Ferreira ML, Doney R, Lau M, Jones T, Dries D, Elliott EJ
Pediatrics 2014 Jul;134(1):e192-209. Epub 2014 Jun 9 doi: 10.1542/peds.2013-3733. PMID: 24913787

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