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Circadian dysregulation

MedGen UID:
208816
•Concept ID:
C0813142
•
Disease or Syndrome
Synonyms: Circadian Dysregulation; Circadian Rhythm Disorder; Circadian Rhythm Disorders; Dysregulation, Circadian
SNOMED CT: Circadian dysregulation (271794005)

Professional guidelines

PubMed

Integration of circadian rhythms and immunotherapy for enhanced precision in brain cancer treatment.
Quist M, van Os M, van Laake LW, Bovenschen N, Crnko S
EBioMedicine 2024 Nov;109:105395. Epub 2024 Oct 15 doi: 10.1016/j.ebiom.2024.105395. PMID: 39413708Free PMC Article
Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease.
Steele TA, St Louis EK, Videnovic A, Auger RR
Neurotherapeutics 2021 Jan;18(1):53-74. Epub 2021 Apr 12 doi: 10.1007/s13311-021-01031-8. PMID: 33844152Free PMC Article
Improving fatigue risk management in healthcare: A scoping review of sleep-related/ fatigue-management interventions for nurses and midwives (reprint).
Querstret D, O'Brien K, Skene DJ, Maben J
Int J Nurs Stud 2020 Dec;112:103745. Epub 2020 Aug 23 doi: 10.1016/j.ijnurstu.2020.103745. PMID: 32847675

Recent clinical studies

Etiology

Stroke in the Time of Circadian Medicine.
Mergenthaler P, Balami JS, Neuhaus AA, Mottahedin A, Albers GW, Rothwell PM, Saver JL, Young ME, Buchan AM
Circ Res 2024 Mar 15;134(6):770-790. Epub 2024 Mar 14 doi: 10.1161/CIRCRESAHA.124.323508. PMID: 38484031
Sleep disorders and Alzheimer's disease pathophysiology: The role of the Glymphatic System. A scoping review.
Astara K, Tsimpolis A, Kalafatakis K, Vavougios GD, Xiromerisiou G, Dardiotis E, Christodoulou NG, Samara MT, Lappas AS
Mech Ageing Dev 2024 Feb;217:111899. Epub 2023 Dec 30 doi: 10.1016/j.mad.2023.111899. PMID: 38163471
Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.
Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Obesity, Chronic Stress, and Stress Reduction.
Goens D, Virzi NE, Jung SE, Rutledge TR, Zarrinpar A
Gastroenterol Clin North Am 2023 Jun;52(2):347-362. Epub 2023 Apr 7 doi: 10.1016/j.gtc.2023.03.009. PMID: 37197878Free PMC Article
Circadian Rhythm Sleep-Wake Disorders.
Zee PC, Abbott SM
Continuum (Minneap Minn) 2020 Aug;26(4):988-1002. doi: 10.1212/CON.0000000000000884. PMID: 32756232

Diagnosis

The engagement of autophagy in maniac disease.
Yang Y, Yuan R, Lu Y, Zhu C, Zhang C, Lue H, Zhang X
CNS Neurosci Ther 2023 Dec;29(12):3684-3692. Epub 2023 Jul 12 doi: 10.1111/cns.14353. PMID: 37438945Free PMC Article
Obesity, Chronic Stress, and Stress Reduction.
Goens D, Virzi NE, Jung SE, Rutledge TR, Zarrinpar A
Gastroenterol Clin North Am 2023 Jun;52(2):347-362. Epub 2023 Apr 7 doi: 10.1016/j.gtc.2023.03.009. PMID: 37197878Free PMC Article
Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease.
Steele TA, St Louis EK, Videnovic A, Auger RR
Neurotherapeutics 2021 Jan;18(1):53-74. Epub 2021 Apr 12 doi: 10.1007/s13311-021-01031-8. PMID: 33844152Free PMC Article
Circadian rhythms, refractive development, and myopia.
Chakraborty R, Ostrin LA, Nickla DL, Iuvone PM, Pardue MT, Stone RA
Ophthalmic Physiol Opt 2018 May;38(3):217-245. doi: 10.1111/opo.12453. PMID: 29691928Free PMC Article
Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.
Alloy LB, Ng TH, Titone MK, Boland EM
Curr Psychiatry Rep 2017 Apr;19(4):21. doi: 10.1007/s11920-017-0772-z. PMID: 28321642Free PMC Article

Therapy

Sleep and circadian health in juvenile justice systems: A descriptive analysis.
Adornetti JP, Woodard KN, Nogales JM, Foster M, Leask L, McGee R, Carlucci M, Crowley SJ, Wolfson AR
Sleep Health 2023 Dec;9(6):876-881. Epub 2023 Oct 2 doi: 10.1016/j.sleh.2023.08.009. PMID: 37793973
Endogenous melatonin levels and therapeutic use of exogenous melatonin in tension type headache: A systematic review.
Liampas I, Siokas V, Brotis A, Mentis AA, Aloizou AM, Dastamani M, Tsouris Z, Lima M, Dardiotis E
Rev Neurol (Paris) 2021 Oct;177(8):871-880. Epub 2021 Jun 22 doi: 10.1016/j.neurol.2021.01.014. PMID: 34167809
Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease.
Steele TA, St Louis EK, Videnovic A, Auger RR
Neurotherapeutics 2021 Jan;18(1):53-74. Epub 2021 Apr 12 doi: 10.1007/s13311-021-01031-8. PMID: 33844152Free PMC Article
Meta-analysis of melatonin levels in cluster headache-Review of clinical implications.
Liampas I, Siokas V, Brotis A, Aloizou AM, Mentis AA, Vikelis M, Dardiotis E
Acta Neurol Scand 2020 Oct;142(4):356-367. Epub 2020 Aug 7 doi: 10.1111/ane.13317. PMID: 32677039
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Bunney BG, Li JZ, Walsh DM, Stein R, Vawter MP, Cartagena P, Barchas JD, Schatzberg AF, Myers RM, Watson SJ, Akil H, Bunney WE
Mol Psychiatry 2015 Feb;20(1):48-55. Epub 2014 Nov 4 doi: 10.1038/mp.2014.138. PMID: 25349171Free PMC Article

Prognosis

Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.
Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Is obstructive sleep apnea a circadian rhythm disorder?
Šmon J, Kočar E, Pintar T, Dolenc-Grošelj L, Rozman D
J Sleep Res 2023 Aug;32(4):e13875. Epub 2023 Mar 15 doi: 10.1111/jsr.13875. PMID: 36922163
Social jetlag and depression in female rotating-shift nurses: A secondary analysis.
Lee H, Jang SJ
Perspect Psychiatr Care 2022 Oct;58(4):2246-2254. Epub 2022 Feb 11 doi: 10.1111/ppc.13054. PMID: 35146748
A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer.
Zhou R, Chen X, Liang J, Chen Q, Tian H, Yang C, Liu C
Aging (Albany NY) 2021 Dec 3;13(23):25153-25179. doi: 10.18632/aging.203733. PMID: 34862329Free PMC Article
Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.
Pinato L, Galina Spilla CS, Markus RP, da Silveira Cruz-Machado S
Curr Pharm Des 2019;25(41):4379-4393. doi: 10.2174/1381612825666191102170450. PMID: 31682208

Clinical prediction guides

Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.
Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Pediatric Intensive Care Unit related Sleep and Circadian Dysregulation: a focused review.
Hassinger AB, Afzal S, Rauth M, Breuer RK
Semin Pediatr Neurol 2023 Dec;48:101077. Epub 2023 Aug 21 doi: 10.1016/j.spen.2023.101077. PMID: 38065630
Human fertility and sleep disturbances: A narrative review.
Spaggiari G, Romeo M, Casarini L, Granata ARM, Simoni M, Santi D
Sleep Med 2022 Oct;98:13-25. Epub 2022 Jun 19 doi: 10.1016/j.sleep.2022.06.009. PMID: 35772248
Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.
Pinato L, Galina Spilla CS, Markus RP, da Silveira Cruz-Machado S
Curr Pharm Des 2019;25(41):4379-4393. doi: 10.2174/1381612825666191102170450. PMID: 31682208
Can Circadian Dysregulation Exacerbate Migraines?
Ong JC, Taylor HL, Park M, Burgess HJ, Fox RS, Snyder S, Rains JC, Espie CA, Wyatt JK
Headache 2018 Jul;58(7):1040-1051. Epub 2018 May 4 doi: 10.1111/head.13310. PMID: 29727473Free PMC Article

Recent systematic reviews

Endogenous melatonin levels and therapeutic use of exogenous melatonin in tension type headache: A systematic review.
Liampas I, Siokas V, Brotis A, Mentis AA, Aloizou AM, Dastamani M, Tsouris Z, Lima M, Dardiotis E
Rev Neurol (Paris) 2021 Oct;177(8):871-880. Epub 2021 Jun 22 doi: 10.1016/j.neurol.2021.01.014. PMID: 34167809
Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis.
Liampas I, Siokas V, Brotis A, Vikelis M, Dardiotis E
Headache 2020 Jul;60(7):1273-1299. Epub 2020 Apr 30 doi: 10.1111/head.13828. PMID: 32352572
Improving fatigue risk management in healthcare: A systematic scoping review of sleep-related/fatigue-management interventions for nurses and midwives.
Querstret D, O'Brien K, Skene DJ, Maben J
Int J Nurs Stud 2020 Jun;106:103513. Epub 2019 Dec 30 doi: 10.1016/j.ijnurstu.2019.103513. PMID: 32283414
Light therapies to improve sleep in intrinsic circadian rhythm sleep disorders and neuro-psychiatric illness: A systematic review and meta-analysis.
Faulkner SM, Bee PE, Meyer N, Dijk DJ, Drake RJ
Sleep Med Rev 2019 Aug;46:108-123. Epub 2019 Apr 30 doi: 10.1016/j.smrv.2019.04.012. PMID: 31108433

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