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Trisomy 15

MedGen UID:
208642
•Concept ID:
C0795856
•
Disease or Syndrome

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 15 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 15

Professional guidelines

PubMed

Prenatal diagnosis of fetuses with absent/hypoplastic nasal bone in second-trimester using chromosomal microarray analysis.
Chen X, Jiang Y, Zeng S, Zhuang J, Lin N
Birth Defects Res 2024 May;116(5):e2351. doi: 10.1002/bdr2.2351. PMID: 38766695
Cytogenetics in the management of clonal chromosomal abnormalities of undetermined significance and persistent polyclonal B-cell lymphocytosis: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Nadal N, Auger N, Bidet A, Nguyen-Khac F
Curr Res Transl Med 2023 Oct-Dec;71(4):103426. Epub 2023 Oct 26 doi: 10.1016/j.retram.2023.103426. PMID: 38016423
Trisomy 15 mosaicism: Challenges in prenatal diagnosis.
Silva M, Alves C, Pedro S, Marques B, Ferreira C, Furtado J, Martins AT, Fernandes R, Correia J, Correia H
Am J Med Genet A 2015 Nov;167A(11):2847-50. Epub 2015 Jun 30 doi: 10.1002/ajmg.a.37229. PMID: 26126738

Recent clinical studies

Etiology

Chromosomal karyotype in chorionic villi of recurrent spontaneous abortion patients.
Du Y, Chen L, Lin J, Zhu J, Zhang N, Qiu X, Li D, Wang L
Biosci Trends 2018;12(1):32-39. doi: 10.5582/bst.2017.01296. PMID: 29553099
Morphology of early intrauterine deaths with full trisomy 15.
Philipp T, Terry J, Feichtinger M, Grillenberger S, Hartmann B, Jirecek S
Prenat Diagn 2018 Mar;38(4):267-272. Epub 2018 Feb 21 doi: 10.1002/pd.5230. PMID: 29420836
Frequency of Chromosomal Abnormalities in Products of Conception.
Teles TM, Paula CM, Ramos MG, Costa HB, Andrade CR, Coxir SA, Penna ML
Rev Bras Ginecol Obstet 2017 Mar;39(3):110-114. Epub 2017 Mar 15 doi: 10.1055/s-0037-1600521. PMID: 28297732Free PMC Article
Mosaic trisomy 15 at amniocentesis: Prenatal diagnosis, molecular genetic analysis and literature review.
Chen CP, Chern SR, Chen YN, Wu PS, Yang CW, Chen LF, Wang W
Taiwan J Obstet Gynecol 2015 Aug;54(4):426-31. doi: 10.1016/j.tjog.2015.06.002. PMID: 26384064
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338

Diagnosis

Hystero-embryoscopy: evaluation and evacuation of spontaneous missed abortions.
Hincapie M, McGrail K, Nezhat C
Fertil Steril 2023 Feb;119(2):331-332. Epub 2022 Nov 17 doi: 10.1016/j.fertnstert.2022.11.015. PMID: 36402428
Morphology of early intrauterine deaths with full trisomy 15.
Philipp T, Terry J, Feichtinger M, Grillenberger S, Hartmann B, Jirecek S
Prenat Diagn 2018 Mar;38(4):267-272. Epub 2018 Feb 21 doi: 10.1002/pd.5230. PMID: 29420836
Mosaic trisomy 15 at amniocentesis: Prenatal diagnosis, molecular genetic analysis and literature review.
Chen CP, Chern SR, Chen YN, Wu PS, Yang CW, Chen LF, Wang W
Taiwan J Obstet Gynecol 2015 Aug;54(4):426-31. doi: 10.1016/j.tjog.2015.06.002. PMID: 26384064
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
Prenatal diagnosis of 47,XX,der(15)t(15;16)(q13;p13.2).
Santolaya-Forgas J, De Leon J, Powell WC, Tonk V
Prenat Diagn 2004 Mar;24(3):209-12. doi: 10.1002/pd.830. PMID: 15057955

Therapy

Cytogenetic analysis of early pregnancy loss after assisted reproduction treatment using intracytoplasmic sperm injection.
Kamar A, Turktekin N, Ozyurt R, Karakus C, Saribal D, Hocaoglu-Emre FS
Ginekol Pol 2021;92(7):475-480. Epub 2021 Apr 12 doi: 10.5603/GP.a2020.0147. PMID: 33844246
A randomized and blinded comparison of qPCR and NGS-based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D, Tao X, Bohrer C, Lonczak A, Xing T, Zimmerman R, Zhan Y, Scott RT Jr, Treff NR
J Assist Reprod Genet 2016 Nov;33(11):1473-1480. Epub 2016 Aug 6 doi: 10.1007/s10815-016-0784-3. PMID: 27497716Free PMC Article
Isolated +15 in bone marrow: disease-associated or a benign finding?
Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, Goswami M, Yin CC, Lu G, Medeiros LJ, Tang G
Leuk Res 2015 Jan;39(1):72-6. Epub 2014 Nov 15 doi: 10.1016/j.leukres.2014.11.005. PMID: 25435027
Characterization of a recurrent translocation t(2;3)(p15-22;q26) occurring in acute myeloid leukaemia.
Trubia M, Albano F, Cavazzini F, Cambrin GR, Quarta G, Fabbiano F, Ciambelli F, Magro D, Hernandezo JM, Mancini M, Diverio D, Pelicci PG, Coco FL, Mecucci C, Specchia G, Rocchi M, Liso V, Castoldi G, Cuneo A
Leukemia 2006 Jan;20(1):48-54. doi: 10.1038/sj.leu.2404020. PMID: 16619048
Trisomy 15 as the sole abnormality in myelodysplastic syndromes: case report and review of the literature.
Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M
Leuk Lymphoma 2003 Mar;44(3):549-51. doi: 10.1080/1042819021000055084. PMID: 12688332

Prognosis

A randomized and blinded comparison of qPCR and NGS-based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D, Tao X, Bohrer C, Lonczak A, Xing T, Zimmerman R, Zhan Y, Scott RT Jr, Treff NR
J Assist Reprod Genet 2016 Nov;33(11):1473-1480. Epub 2016 Aug 6 doi: 10.1007/s10815-016-0784-3. PMID: 27497716Free PMC Article
Mosaic trisomy 15 in a liveborn infant.
McPadden J, Helm BM, Spangler BB, Ross LP, Boles DB, Schrier Vergano SA
Am J Med Genet A 2015 Apr;167A(4):821-5. Epub 2015 Mar 3 doi: 10.1002/ajmg.a.36958. PMID: 25736076
Trisomy 15 as the sole abnormality in myelodysplastic syndromes: case report and review of the literature.
Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M
Leuk Lymphoma 2003 Mar;44(3):549-51. doi: 10.1080/1042819021000055084. PMID: 12688332
Third Prader-Willi syndrome phenotype due to maternal uniparental disomy 15 with mosaic trisomy 15.
Olander E, Stamberg J, Steinberg L, Wulfsberg EA
Am J Med Genet 2000 Jul 31;93(3):215-8. doi: 10.1002/1096-8628(20000731)93:3<215::aid-ajmg11>3.0.co;2-k. PMID: 10925385
Frequency of trisomy 15 and loss of the Y chromosome in adult leukemia.
Smith A, Watson N, Sharma P
Cancer Genet Cytogenet 1999 Oct 15;114(2):108-11. doi: 10.1016/s0165-4608(99)00042-4. PMID: 10549265

Clinical prediction guides

Placental Expression of the Forelimb Patterning Transcription Factor MEIS2 in Trisomy 15.
Pors J, Philipp T, Terry J
Fetal Pediatr Pathol 2021 Dec;40(6):597-604. Epub 2020 Mar 6 doi: 10.1080/15513815.2020.1732509. PMID: 32138576
Morphology of early intrauterine deaths with full trisomy 15.
Philipp T, Terry J, Feichtinger M, Grillenberger S, Hartmann B, Jirecek S
Prenat Diagn 2018 Mar;38(4):267-272. Epub 2018 Feb 21 doi: 10.1002/pd.5230. PMID: 29420836
Frequency of Chromosomal Abnormalities in Products of Conception.
Teles TM, Paula CM, Ramos MG, Costa HB, Andrade CR, Coxir SA, Penna ML
Rev Bras Ginecol Obstet 2017 Mar;39(3):110-114. Epub 2017 Mar 15 doi: 10.1055/s-0037-1600521. PMID: 28297732Free PMC Article
Trisomy 15 in a case of pediatric hemangiopericytoma and review of the literature.
Vadlamani I, Ma E, Brink DS, Batanian JR
Cancer Genet Cytogenet 2002 Oct 15;138(2):116-9. doi: 10.1016/s0165-4608(02)00590-3. PMID: 12505255
Trisomy 15 is frequently observed as a minor clone in patients with Anemia/MDS/NHL and as a major clone in patients with AML.
Batanian JR, Slovak ML, Mohamed A, Dobin S, Luthardt FW, Keitges EA
Cancer Genet Cytogenet 2000 Sep;121(2):186-9. doi: 10.1016/s0165-4608(00)00253-3. PMID: 11063805

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