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Hypoxic Ischemic Encephalopathy

MedGen UID:
156258
Concept ID:
C0752304
Disease or Syndrome
Synonyms: Encephalopathies, Hypoxic-Ischemic; Encephalopathies, Ischemic-Hypoxic; Encephalopathy, Hypoxic Ischemic; Encephalopathy, Hypoxic-Ischemic; Encephalopathy, Ischemic-Hypoxic; Hypoxic-Ischemic Encephalopathies; Hypoxic-Ischemic Encephalopathy; Ischemic Hypoxic Encephalopathy; Ischemic-Hypoxic Encephalopathies; Ischemic-Hypoxic Encephalopathy
SNOMED CT: Hypoxic ischemic encephalopathy (703300001); Hypoxic ischemic brain injury (703300001)

Definition

Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
O'Shea TM
Clin Obstet Gynecol 2008 Dec;51(4):816-28. doi: 10.1097/GRF.0b013e3181870ba7. PMID: 18981805Free PMC Article

Recent clinical studies

Etiology

Ristovska S, Stomnaroska O, Danilovski D
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2022 Apr 22;43(1):77-84. doi: 10.2478/prilozi-2022-0013. PMID: 35451288
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
Juul SE, Pet GC
Clin Perinatol 2015 Sep;42(3):469-81. Epub 2015 May 14 doi: 10.1016/j.clp.2015.04.004. PMID: 26250911Free PMC Article

Diagnosis

Ristovska S, Stomnaroska O, Danilovski D
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2022 Apr 22;43(1):77-84. doi: 10.2478/prilozi-2022-0013. PMID: 35451288
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Russ JB, Simmons R, Glass HC
Neoreviews 2021 Mar;22(3):e148-e162. doi: 10.1542/neo.22-3-e148. PMID: 33649088
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Douglas-Escobar M, Weiss MD
JAMA Pediatr 2015 Apr;169(4):397-403. doi: 10.1001/jamapediatrics.2014.3269. PMID: 25685948

Therapy

Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Gunn AJ, Thoresen M
Handb Clin Neurol 2019;162:217-237. doi: 10.1016/B978-0-444-64029-1.00010-2. PMID: 31324312
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Silveira RC, Procianoy RS
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S78-83. Epub 2015 Sep 4 doi: 10.1016/j.jped.2015.07.004. PMID: 26354871
Douglas-Escobar M, Weiss MD
JAMA Pediatr 2015 Apr;169(4):397-403. doi: 10.1001/jamapediatrics.2014.3269. PMID: 25685948

Prognosis

Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Henson T, Rawanduzy C, Salazar M, Sebastian A, Weber H, Al-Mufti F, Mayer SA
Ann N Y Acad Sci 2022 Feb;1508(1):23-34. Epub 2021 Sep 27 doi: 10.1111/nyas.14699. PMID: 34580886
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network
N Engl J Med 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929. PMID: 16221780

Clinical prediction guides

Wu YW, Monsell SE, Glass HC, Wisnowski JL, Mathur AM, McKinstry RC, Bluml S, Gonzalez FF, Comstock BA, Heagerty PJ, Juul SE
Pediatr Res 2023 Sep;94(3):1018-1025. Epub 2023 Mar 1 doi: 10.1038/s41390-023-02510-8. PMID: 36859442Free PMC Article
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Finder M, Boylan GB, Twomey D, Ahearne C, Murray DM, Hallberg B
JAMA Pediatr 2020 Jan 1;174(1):48-55. doi: 10.1001/jamapediatrics.2019.4011. PMID: 31710357Free PMC Article
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437
Natarajan G, Pappas A, Shankaran S
Semin Perinatol 2016 Dec;40(8):549-555. Epub 2016 Nov 15 doi: 10.1053/j.semperi.2016.09.007. PMID: 27863707Free PMC Article

Recent systematic reviews

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Bäcke P, Bruschettini M, Sibrecht G, Thernström Blomqvist Y, Olsson E
Cochrane Database Syst Rev 2022 Nov 10;11(11):CD015023. doi: 10.1002/14651858.CD015023.pub2. PMID: 36354070Free PMC Article
Starr MC, Charlton JR, Guillet R, Reidy K, Tipple TE, Jetton JG, Kent AL, Abitbol CL, Ambalavanan N, Mhanna MJ, Askenazi DJ, Selewski DT, Harer MW; Neonatal Kidney Collaborative Board
Pediatrics 2021 Nov;148(5) Epub 2021 Oct 1 doi: 10.1542/peds.2021-051220. PMID: 34599008
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article

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