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Spinal cord ischemia

MedGen UID:
155706
•Concept ID:
C0752130
•
Disease or Syndrome
Synonyms: Cord Ischemia, Spinal; Cord Ischemias, Spinal; Ischemia, Spinal Cord; Ischemias, Spinal Cord; Ischemic Myelopathies; Ischemic Myelopathy; Myelopathies, Ischemic; Myelopathy, Ischemic; Spinal Cord Ischemia; Spinal Cord Ischemias
SNOMED CT: Ischemic disorder of spinal cord (371029002); Ischemia of spinal cord (371029002); Spinal cord ischemia (371029002)
 
Monarch Initiative: MONDO:0020688

Definition

Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with arteriosclerosis, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to infarction of spinal cord tissue. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal cord ischemia

Professional guidelines

PubMed

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Prevention and management of spinal cord ischemia following aortic surgery: A survey of contemporary practice.
Chung JC, Lodewyks CL, Forbes TL, Chu MWA, Peterson MD, Arora RC, Ouzounian M; Canadian Thoracic Aortic Collaborative (CTAC); Canadian Cardiovascular Critical Care (CANCARE) Society
J Thorac Cardiovasc Surg 2022 Jan;163(1):16-23.e7. Epub 2020 Mar 21 doi: 10.1016/j.jtcvs.2020.03.034. PMID: 32334886
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910

Recent clinical studies

Etiology

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Approach to Myelopathy and Myelitis.
Douglas AG, Xu DJ, Shah MP
Neurol Clin 2022 Feb;40(1):133-156. doi: 10.1016/j.ncl.2021.08.009. PMID: 34798966
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910

Diagnosis

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Approach to Myelopathy and Myelitis.
Douglas AG, Xu DJ, Shah MP
Neurol Clin 2022 Feb;40(1):133-156. doi: 10.1016/j.ncl.2021.08.009. PMID: 34798966
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Vascular myelopathies.
Moftakhar P, Hetts SW, Ko NU
Semin Neurol 2012 Apr;32(2):146-53. Epub 2012 Sep 8 doi: 10.1055/s-0032-1322585. PMID: 22961189

Therapy

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Spinal Cord Protection for Thoracoabdominal Aortic Surgery.
Miller LK, Patel VI, Wagener G
J Cardiothorac Vasc Anesth 2022 Feb;36(2):577-586. Epub 2021 Jun 26 doi: 10.1053/j.jvca.2021.06.024. PMID: 34366215
Strategies to prevent TEVAR-related spinal cord ischemia.
Dias-Neto M, Reis PV, Rolim D, Ramos JF, Teixeira JF, Sampaio S
Vascular 2017 Jun;25(3):307-315. Epub 2016 Sep 30 doi: 10.1177/1708538116671235. PMID: 27694555
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910
Spinal cord ischemia after aortic surgery.
Davidovic L, Ilic N
J Cardiovasc Surg (Torino) 2014 Dec;55(6):741-57. Epub 2014 Jul 14 PMID: 25017787

Prognosis

Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910
Spinal cord ischemia is multifactorial: what is the best protocol?
Melissano G, Bertoglio L, Mascia D, Rinaldi E, Del Carro U, Nardelli P, Chiesa R
J Cardiovasc Surg (Torino) 2016 Apr;57(2):191-201. Epub 2016 Jan 15 PMID: 26731537
Acute Spinal Cord Injury.
Witiw CD, Fehlings MG
J Spinal Disord Tech 2015 Jul;28(6):202-10. doi: 10.1097/BSD.0000000000000287. PMID: 26098670
Spinal cord ischemia: practical imaging tips, pearls, and pitfalls.
Vargas MI, Gariani J, Sztajzel R, Barnaure-Nachbar I, Delattre BM, Lovblad KO, Dietemann JL
AJNR Am J Neuroradiol 2015 May;36(5):825-30. Epub 2014 Oct 16 doi: 10.3174/ajnr.A4118. PMID: 25324492Free PMC Article

Clinical prediction guides

Predictors and outcomes of spinal cord injury following complex branched/fenestrated endovascular aortic repair in the US Aortic Research Consortium.
Aucoin VJ, Motyl CM, Novak Z, Eagleton MJ, Farber MA, Gasper W, Oderich GS, Mendes B, Schanzer A, Tenorio E, Timaran CH, Schneider DB, Sweet MP, Zettervall SL, Beck AW; U.S. Aortic Research Consortium
J Vasc Surg 2023 Jun;77(6):1578-1587. Epub 2023 Apr 13 doi: 10.1016/j.jvs.2023.01.205. PMID: 37059239
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Ischemic Tolerance of the Brain and Spinal Cord: A Review.
Yunoki M, Kanda T, Suzuki K, Uneda A, Hirashita K, Yoshino K
Neurol Med Chir (Tokyo) 2017 Nov 15;57(11):590-600. Epub 2017 Sep 27 doi: 10.2176/nmc.ra.2017-0062. PMID: 28954945Free PMC Article
Nontraumatic spinal cord ischaemic syndrome.
Rigney L, Cappelen-Smith C, Sebire D, Beran RG, Cordato D
J Clin Neurosci 2015 Oct;22(10):1544-9. Epub 2015 Jul 4 doi: 10.1016/j.jocn.2015.03.037. PMID: 26154150
Spinal cord injury following thoracic and thoracoabdominal aortic repairs.
Panthee N, Ono M
Asian Cardiovasc Thorac Ann 2015 Feb;23(2):235-46. Epub 2014 Sep 1 doi: 10.1177/0218492314548901. PMID: 25178467

Recent systematic reviews

Cancer-associated spinal cord infarction: A systematic review and analysis of survival predictors.
Puente-Hernandez M, Rivero-de-Aguilar A, Varela-Lema L
J Neurol Sci 2023 Mar 15;446:120580. Epub 2023 Feb 4 doi: 10.1016/j.jns.2023.120580. PMID: 36764185
Preparing the spinal cord - priming or preconditioning? A systematic review of experimental studies.
Herajärvi J, Juvonen T
Scand Cardiovasc J 2023 Dec;57(1):2166100. doi: 10.1080/14017431.2023.2166100. PMID: 36660818
A systematic review of spinal cord ischemia prevention and management after open and endovascular aortic repair.
Lella SK, Waller HD, Pendleton A, Latz CA, Boitano LT, Dua A
J Vasc Surg 2022 Mar;75(3):1091-1106. Epub 2021 Nov 2 doi: 10.1016/j.jvs.2021.10.039. PMID: 34740806
Open repair of thoracoabdominal aortic aneurysms in experienced centers.
Moulakakis KG, Karaolanis G, Antonopoulos CN, Kakisis J, Klonaris C, Preventza O, Coselli JS, Geroulakos G
J Vasc Surg 2018 Aug;68(2):634-645.e12. doi: 10.1016/j.jvs.2018.03.410. PMID: 30037680
A systematic review of spinal cord injury and cerebrospinal fluid drainage after thoracic aortic endografting.
Wong CS, Healy D, Canning C, Coffey JC, Boyle JR, Walsh SR
J Vasc Surg 2012 Nov;56(5):1438-47. Epub 2012 Aug 9 doi: 10.1016/j.jvs.2012.05.075. PMID: 22884456

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