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Spinal cord ischemia

MedGen UID:
155706
•Concept ID:
C0752130
•
Disease or Syndrome
Synonyms: Cord Ischemia, Spinal; Cord Ischemias, Spinal; Ischemia, Spinal Cord; Ischemias, Spinal Cord; Ischemic Myelopathies; Ischemic Myelopathy; Myelopathies, Ischemic; Myelopathy, Ischemic; Spinal Cord Ischemia; Spinal Cord Ischemias
SNOMED CT: Ischemic disorder of spinal cord (371029002); Ischemia of spinal cord (371029002); Spinal cord ischemia (371029002)
 
Monarch Initiative: MONDO:0020688

Definition

Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with arteriosclerosis, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to infarction of spinal cord tissue. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal cord ischemia

Professional guidelines

PubMed

Endovascular Management of Life-Threatening Hemoptysis in Primary Lung Cancer: A Retrospective Study.
Le Tat T, Carlier R, Zhang N, Bouchet A, Amar R, Zhou J, El Hajjam M
Cardiovasc Intervent Radiol 2023 Jul;46(7):891-900. Epub 2023 Jun 13 doi: 10.1007/s00270-023-03488-w. PMID: 37311841
Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910

Recent clinical studies

Etiology

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Approach to Myelopathy and Myelitis.
Douglas AG, Xu DJ, Shah MP
Neurol Clin 2022 Feb;40(1):133-156. doi: 10.1016/j.ncl.2021.08.009. PMID: 34798966
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Postoperative management.
Schraag S
Best Pract Res Clin Anaesthesiol 2016 Sep;30(3):381-93. Epub 2016 Jun 9 doi: 10.1016/j.bpa.2016.06.001. PMID: 27650347

Diagnosis

Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Neuromonitoring during descending aorta procedures.
Simon MV, Dong CC, Jacobs MJ, Mess WH
Handb Clin Neurol 2022;186:407-431. doi: 10.1016/B978-0-12-819826-1.00010-7. PMID: 35772899
Approach to Myelopathy and Myelitis.
Douglas AG, Xu DJ, Shah MP
Neurol Clin 2022 Feb;40(1):133-156. doi: 10.1016/j.ncl.2021.08.009. PMID: 34798966
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Bronchial artery embolization.
Kalva SP
Tech Vasc Interv Radiol 2009 Jun;12(2):130-8. doi: 10.1053/j.tvir.2009.08.006. PMID: 19853230

Therapy

Spinal cord protection in open and endovascular approaches to thoracoabdominal aortic aneurysms.
Amabile A, Lewis E, Costa V, Tadros RO, Han DK, Di Luozzo G
Vascular 2023 Oct;31(5):874-883. Epub 2022 May 4 doi: 10.1177/17085381221094411. PMID: 35507464
Strategies for prevention and treatment of spinal cord ischemia during F/BEVAR.
Motyl CM, Beck AW
Semin Vasc Surg 2022 Sep;35(3):297-305. Epub 2022 Jul 3 doi: 10.1053/j.semvascsurg.2022.06.005. PMID: 36153070
Interventions to improve perioperative neurologic outcomes.
Vandiver MS, Vacas S
Curr Opin Anaesthesiol 2020 Oct;33(5):661-667. doi: 10.1097/ACO.0000000000000905. PMID: 32769748Free PMC Article
Strategies to prevent TEVAR-related spinal cord ischemia.
Dias-Neto M, Reis PV, Rolim D, Ramos JF, Teixeira JF, Sampaio S
Vascular 2017 Jun;25(3):307-315. Epub 2016 Sep 30 doi: 10.1177/1708538116671235. PMID: 27694555
Spinal cord ischemia after aortic surgery.
Davidovic L, Ilic N
J Cardiovasc Surg (Torino) 2014 Dec;55(6):741-57. Epub 2014 Jul 14 PMID: 25017787

Prognosis

Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Postoperative management.
Schraag S
Best Pract Res Clin Anaesthesiol 2016 Sep;30(3):381-93. Epub 2016 Jun 9 doi: 10.1016/j.bpa.2016.06.001. PMID: 27650347
Current and emerging treatment options for spinal cord ischemia.
Nardone R, Pikija S, Mutzenbach JS, Seidl M, Leis S, Trinka E, Sellner J
Drug Discov Today 2016 Oct;21(10):1632-1641. Epub 2016 Jun 17 doi: 10.1016/j.drudis.2016.06.015. PMID: 27326910
Acute Spinal Cord Injury.
Witiw CD, Fehlings MG
J Spinal Disord Tech 2015 Jul;28(6):202-10. doi: 10.1097/BSD.0000000000000287. PMID: 26098670
Spinal cord ischemia: practical imaging tips, pearls, and pitfalls.
Vargas MI, Gariani J, Sztajzel R, Barnaure-Nachbar I, Delattre BM, Lovblad KO, Dietemann JL
AJNR Am J Neuroradiol 2015 May;36(5):825-30. Epub 2014 Oct 16 doi: 10.3174/ajnr.A4118. PMID: 25324492Free PMC Article

Clinical prediction guides

A narrative review: The pharmaceutical evolution of phenolic syringaldehyde.
Wu J, Fu YS, Lin K, Huang X, Chen YJ, Lai D, Kang N, Huang L, Weng CF
Biomed Pharmacother 2022 Sep;153:113339. Epub 2022 Jun 30 doi: 10.1016/j.biopha.2022.113339. PMID: 35780614
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Ischemic Tolerance of the Brain and Spinal Cord: A Review.
Yunoki M, Kanda T, Suzuki K, Uneda A, Hirashita K, Yoshino K
Neurol Med Chir (Tokyo) 2017 Nov 15;57(11):590-600. Epub 2017 Sep 27 doi: 10.2176/nmc.ra.2017-0062. PMID: 28954945Free PMC Article
Nontraumatic spinal cord ischaemic syndrome.
Rigney L, Cappelen-Smith C, Sebire D, Beran RG, Cordato D
J Clin Neurosci 2015 Oct;22(10):1544-9. Epub 2015 Jul 4 doi: 10.1016/j.jocn.2015.03.037. PMID: 26154150
Spinal cord ischemia: aetiology, clinical syndromes and imaging features.
Weidauer S, Nichtweiß M, Hattingen E, Berkefeld J
Neuroradiology 2015 Mar;57(3):241-57. Epub 2014 Nov 16 doi: 10.1007/s00234-014-1464-6. PMID: 25398656

Recent systematic reviews

Postoperative Spinal Cord Ischemia Monitoring: A Review of Techniques Available after Endovascular Aortic Repair.
Soliman MA, Ramadan A, Shah AS, Corr SJ, Abdelazeem B, Rahimi M
Ann Vasc Surg 2024 Sep;106:438-466. Epub 2024 May 28 doi: 10.1016/j.avsg.2024.03.022. PMID: 38815914
Cancer-associated spinal cord infarction: A systematic review and analysis of survival predictors.
Puente-Hernandez M, Rivero-de-Aguilar A, Varela-Lema L
J Neurol Sci 2023 Mar 15;446:120580. Epub 2023 Feb 4 doi: 10.1016/j.jns.2023.120580. PMID: 36764185
Preparing the spinal cord - priming or preconditioning? A systematic review of experimental studies.
Herajärvi J, Juvonen T
Scand Cardiovasc J 2023 Dec;57(1):2166100. doi: 10.1080/14017431.2023.2166100. PMID: 36660818
Open repair of thoracoabdominal aortic aneurysms in experienced centers.
Moulakakis KG, Karaolanis G, Antonopoulos CN, Kakisis J, Klonaris C, Preventza O, Coselli JS, Geroulakos G
J Vasc Surg 2018 Aug;68(2):634-645.e12. doi: 10.1016/j.jvs.2018.03.410. PMID: 30037680
A systematic review of spinal cord injury and cerebrospinal fluid drainage after thoracic aortic endografting.
Wong CS, Healy D, Canning C, Coffey JC, Boyle JR, Walsh SR
J Vasc Surg 2012 Nov;56(5):1438-47. Epub 2012 Aug 9 doi: 10.1016/j.jvs.2012.05.075. PMID: 22884456

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