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Relapsing remitting multiple sclerosis

MedGen UID:
155669
Concept ID:
C0751967
Disease or Syndrome
Synonyms: Multiple Sclerosis, Relapsing Remitting; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Remitting-Relapsing; Relapsing Remitting Multiple Sclerosis; Relapsing-Remitting Multiple Sclerosis; Remitting Relapsing Multiple Sclerosis; Remitting-Relapsing Multiple Sclerosis
SNOMED CT: Relapsing remitting multiple sclerosis (426373005); Multiple sclerosis (MS) relapsing remitting (426373005)
 
Monarch Initiative: MONDO:0005314

Definition

A type of multiple sclerosis characterized by intermittent flare-ups with a return to few or no symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRelapsing remitting multiple sclerosis

Professional guidelines

PubMed

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Correale J, Gaitán MI, Ysrraelit MC, Fiol MP
Brain 2017 Mar 1;140(3):527-546. doi: 10.1093/brain/aww258. PMID: 27794524
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Svenningsson A, Frisell T, Burman J, Salzer J, Fink K, Hallberg S, Hambraeus J, Axelsson M, Nimer FA, Sundström P, Gunnarsson M, Johansson R, Mellergård J, Rosenstein I, Ayad A, Sjöblom I, Risedal A, de Flon P, Gilland E, Lindeberg J, Shawket F, Piehl F, Lycke J
Lancet Neurol 2022 Aug;21(8):693-703. doi: 10.1016/S1474-4422(22)00209-5. PMID: 35841908
Kaegi C, Wuest B, Crowley C, Boyman O
Front Immunol 2021;12:788830. Epub 2022 Feb 2 doi: 10.3389/fimmu.2021.788830. PMID: 35185862Free PMC Article
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, Rieckmann P, Comi G, Dangond F, Adeniji AK, Vermersch P
Mult Scler 2018 Oct;24(12):1594-1604. Epub 2017 Sep 5 doi: 10.1177/1352458517727603. PMID: 28870107
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Diagnosis

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Olek MJ
Ann Intern Med 2021 Jun;174(6):ITC81-ITC96. Epub 2021 Jun 8 doi: 10.7326/AITC202106150. PMID: 34097429
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Klotz L, Antel J, Kuhlmann T
Nat Rev Neurol 2023 May;19(5):305-320. Epub 2023 Apr 14 doi: 10.1038/s41582-023-00801-6. PMID: 37059811
Svenningsson A, Frisell T, Burman J, Salzer J, Fink K, Hallberg S, Hambraeus J, Axelsson M, Nimer FA, Sundström P, Gunnarsson M, Johansson R, Mellergård J, Rosenstein I, Ayad A, Sjöblom I, Risedal A, de Flon P, Gilland E, Lindeberg J, Shawket F, Piehl F, Lycke J
Lancet Neurol 2022 Aug;21(8):693-703. doi: 10.1016/S1474-4422(22)00209-5. PMID: 35841908
Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, Rieckmann P, Comi G, Dangond F, Adeniji AK, Vermersch P
Mult Scler 2018 Oct;24(12):1594-1604. Epub 2017 Sep 5 doi: 10.1177/1352458517727603. PMID: 28870107
Giovannoni G, Comi G, Cook S, Rammohan K, Rieckmann P, Soelberg Sørensen P, Vermersch P, Chang P, Hamlett A, Musch B, Greenberg SJ; CLARITY Study Group
N Engl J Med 2010 Feb 4;362(5):416-26. Epub 2010 Jan 20 doi: 10.1056/NEJMoa0902533. PMID: 20089960
Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, Bar-Or A, Panzara M, Sarkar N, Agarwal S, Langer-Gould A, Smith CH; HERMES Trial Group
N Engl J Med 2008 Feb 14;358(7):676-88. doi: 10.1056/NEJMoa0706383. PMID: 18272891

Prognosis

Bhan V, Clift F, Baharnoori M, Thomas K, Patel BP, Blanchette F, Adlard N, Vudumula U, Gudala K, Dutta N, Grima D, Mouallif S, Farhane F
J Comp Eff Res 2023 Sep;12(9):e220175. Epub 2023 Aug 22 doi: 10.57264/cer-2022-0175. PMID: 37606897Free PMC Article
Zhuo Z, Li Y, Duan Y, Cao G, Zheng F, Ding J, Tian D, Wang X, Wang J, Zhang X, Li K, Zhou F, Huang M, Li Y, Li H, Zeng C, Zhang N, Sun J, Yu C, Han X, Haller S, Barkhof F, Shi F, Liu Y
J Neurol 2021 May;268(5):1808-1817. Epub 2021 Jan 2 doi: 10.1007/s00415-020-10376-7. PMID: 33387013
He A, Merkel B, Brown JWL, Zhovits Ryerson L, Kister I, Malpas CB, Sharmin S, Horakova D, Kubala Havrdova E, Spelman T, Izquierdo G, Eichau S, Trojano M, Lugaresi A, Hupperts R, Sola P, Ferraro D, Lycke J, Grand'Maison F, Prat A, Girard M, Duquette P, Larochelle C, Svenningsson A, Petersen T, Grammond P, Granella F, Van Pesch V, Bergamaschi R, McGuigan C, Coles A, Hillert J, Piehl F, Butzkueven H, Kalincik T; MSBase study group
Lancet Neurol 2020 Apr;19(4):307-316. Epub 2020 Mar 18 doi: 10.1016/S1474-4422(20)30067-3. PMID: 32199096
Bar-Or A, Grove RA, Austin DJ, Tolson JM, VanMeter SA, Lewis EW, Derosier FJ, Lopez MC, Kavanagh ST, Miller AE, Sorensen PS
Neurology 2018 May 15;90(20):e1805-e1814. Epub 2018 Apr 25 doi: 10.1212/WNL.0000000000005516. PMID: 29695594Free PMC Article
Gallo P, Van Wijmeersch B; ParadigMS Group
Eur J Neurol 2015 Oct;22 Suppl 2:14-21. doi: 10.1111/ene.12799. PMID: 26374509

Clinical prediction guides

Sainz de la Maza S, Maurino J, Borges M, Martín-Martínez J, Sotoca J, Alonso A, Caminero AB, Borrega L, Sánchez-Menoyo JL, Barrero-Hernández FJ, Calles C, Brieva L, Blasco MR, García-Soto JD, Campo-Amigo MD, Navarro-Cantó L, Agüera E, Garcés M, Carmona O, Gabaldón-Torres L, Forero L, Hervás M, de Alda LR, Gómez-Ballesteros R, Castillo-Triviño T
Mult Scler Relat Disord 2022 Feb;58:103398. Epub 2021 Nov 10 doi: 10.1016/j.msard.2021.103398. PMID: 35216781
Spelman T, Magyari M, Piehl F, Svenningsson A, Rasmussen PV, Kant M, Sellebjerg F, Joensen H, Hillert J, Lycke J
JAMA Neurol 2021 Oct 1;78(10):1197-1204. doi: 10.1001/jamaneurol.2021.2738. PMID: 34398221Free PMC Article
Rodrigues R, Rocha R, Bonifácio G, Ferro D, Sabença F, Gonçalves AI, Correia F, Pinheiro J, Loureiro JL, Guerreiro RP, Vale J, Sá MJ, Costa A
Mult Scler Relat Disord 2021 Oct;55:103176. Epub 2021 Jul 27 doi: 10.1016/j.msard.2021.103176. PMID: 34343868
Odintsova TA, Kopchak OO
Wiad Lek 2021;74(2):257-262. PMID: 33813482
Zhuo Z, Li Y, Duan Y, Cao G, Zheng F, Ding J, Tian D, Wang X, Wang J, Zhang X, Li K, Zhou F, Huang M, Li Y, Li H, Zeng C, Zhang N, Sun J, Yu C, Han X, Haller S, Barkhof F, Shi F, Liu Y
J Neurol 2021 May;268(5):1808-1817. Epub 2021 Jan 2 doi: 10.1007/s00415-020-10376-7. PMID: 33387013

Recent systematic reviews

Gonzalez-Lorenzo M, Ridley B, Minozzi S, Del Giovane C, Peryer G, Piggott T, Foschi M, Filippini G, Tramacere I, Baldin E, Nonino F
Cochrane Database Syst Rev 2024 Jan 4;1(1):CD011381. doi: 10.1002/14651858.CD011381.pub3. PMID: 38174776Free PMC Article
Montalban X, Matthews PM, Simpson A, Petrie JL, Sammon C, Ramagopalan S, Disanto G, Kuhle J
Ann Clin Transl Neurol 2023 Mar;10(3):302-311. Epub 2023 Feb 2 doi: 10.1002/acn3.51732. PMID: 36728340Free PMC Article
Liu Z, Liao Q, Wen H, Zhang Y
Autoimmun Rev 2021 Jun;20(6):102826. Epub 2021 Apr 18 doi: 10.1016/j.autrev.2021.102826. PMID: 33878488
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

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