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Paraneoplastic encephalomyelitis

MedGen UID:
199763
•Concept ID:
C0751912
•
Disease or Syndrome
Synonyms: Encephalomyelitis, Paraneoplastic; Paraneoplastic Encephalomyelitides; Paraneoplastic Encephalomyelitis
SNOMED CT: Paraneoplastic encephalomyelitis (424761009)

Professional guidelines

PubMed

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318
Clinical outcome of patients with anti-Hu-associated encephalomyelitis after treatment of the tumor.
Keime-Guibert F, Graus F, Broët P, Reñé R, Molinuevo JL, Ascaso C, Delattre JY
Neurology 1999 Nov 10;53(8):1719-23. doi: 10.1212/wnl.53.8.1719. PMID: 10563618
Plasmapheresis and antineoplastic treatment in CNS paraneoplastic syndromes with antineuronal autoantibodies.
Graus F, Vega F, Delattre JY, Bonaventura I, Reñé R, Arbaiza D, Tolosa E
Neurology 1992 Mar;42(3 Pt 1):536-40. doi: 10.1212/wnl.42.3.536. PMID: 1312683

Recent clinical studies

Etiology

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318
The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review.
Budhram A, Nicolle MW, Yang L
Can J Neurol Sci 2018 Sep;45(5):577-579. doi: 10.1017/cjn.2018.74. PMID: 30234468
Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review.
Braik T, Evans AT, Telfer M, McDunn S
Am J Med Sci 2010 Oct;340(4):301-8. doi: 10.1097/MAJ.0b013e3181d9bb3b. PMID: 20460982
Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer.
Rojas-Marcos I, Rousseau A, Keime-Guibert F, Reñé R, Cartalat-Carel S, Delattre JY, Graus F
Medicine (Baltimore) 2003 May;82(3):216-23. doi: 10.1097/01.md.0000076004.64510.ce. PMID: 12792307
Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Dropcho EJ
Ann Neurol 1995 May;37 Suppl 1:S102-13. doi: 10.1002/ana.410370711. PMID: 8968221

Diagnosis

Paraneoplastic antibodies targeting intracellular antigens.
Linnoila JJ
Handb Clin Neurol 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9. PMID: 38494288
Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318
Neurologic complications of lung cancer.
Dropcho EJ
Handb Clin Neurol 2014;119:335-61. doi: 10.1016/B978-0-7020-4086-3.00022-9. PMID: 24365305
Paraneoplastic neurological syndromes and onconeural antibodies: clinical and immunological aspects.
Storstein A, Vedeler CA
Adv Clin Chem 2007;44:143-85. doi: 10.1016/s0065-2423(07)44005-7. PMID: 17682342
Neuro-ophthalmology and paraneoplastic syndromes.
Bataller L, Dalmau J
Curr Opin Neurol 2004 Feb;17(1):3-8. doi: 10.1097/00019052-200402000-00003. PMID: 15090871

Therapy

Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy.
Sillevis Smitt P, Grefkens J, de Leeuw B, van den Bent M, van Putten W, Hooijkaas H, Vecht C
J Neurol 2002 Jun;249(6):745-53. doi: 10.1007/s00415-002-0706-4. PMID: 12111309
Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas.
Torà M, Graus F, de Bolòs C, Real FX
Neurology 1997 Mar;48(3):735-41. doi: 10.1212/wnl.48.3.735. PMID: 9065557
Autoimmune central nervous system paraneoplastic disorders: mechanisms, diagnosis, and therapeutic options.
Dropcho EJ
Ann Neurol 1995 May;37 Suppl 1:S102-13. doi: 10.1002/ana.410370711. PMID: 8968221
Anti-tumour therapy in paraneoplastic neurological disease.
Grisold W, Drlicek M, Liszka-Setinek U, Wondrusch E
Clin Neurol Neurosurg 1995 Feb;97(1):106-11. doi: 10.1016/0303-8467(95)00003-3. PMID: 7788965
Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice.
Sillevis Smitt PA, Manley GT, Posner JB
Neurology 1995 Oct;45(10):1873-8. doi: 10.1212/wnl.45.10.1873. PMID: 7477985

Prognosis

The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review.
Budhram A, Nicolle MW, Yang L
Can J Neurol Sci 2018 Sep;45(5):577-579. doi: 10.1017/cjn.2018.74. PMID: 30234468
Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies.
Ariño H, Höftberger R, Gresa-Arribas N, Martínez-Hernández E, Armangue T, Kruer MC, Arpa J, Domingo J, Rojc B, Bataller L, Saiz A, Dalmau J, Graus F
JAMA Neurol 2015 Aug;72(8):874-81. doi: 10.1001/jamaneurol.2015.0749. PMID: 26099072Free PMC Article
Creutzfeldt-Jakob disease: a case report and differential diagnoses.
Kojima G, Tatsuno BK, Inaba M, Velligas S, Masaki K, Liow KK
Hawaii J Med Public Health 2013 Apr;72(4):136-9. PMID: 23795314Free PMC Article
Paraneoplastic neurological syndromes and onconeural antibodies: clinical and immunological aspects.
Storstein A, Vedeler CA
Adv Clin Chem 2007;44:143-85. doi: 10.1016/s0065-2423(07)44005-7. PMID: 17682342
Clinical and pathological advances on central nervous system paraneoplastic syndromes.
Graus F, René R
Rev Neurol (Paris) 1992;148(6-7):496-501. PMID: 1448670

Clinical prediction guides

The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review.
Budhram A, Nicolle MW, Yang L
Can J Neurol Sci 2018 Sep;45(5):577-579. doi: 10.1017/cjn.2018.74. PMID: 30234468
Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies.
Ariño H, Höftberger R, Gresa-Arribas N, Martínez-Hernández E, Armangue T, Kruer MC, Arpa J, Domingo J, Rojc B, Bataller L, Saiz A, Dalmau J, Graus F
JAMA Neurol 2015 Aug;72(8):874-81. doi: 10.1001/jamaneurol.2015.0749. PMID: 26099072Free PMC Article
Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy.
Sillevis Smitt P, Grefkens J, de Leeuw B, van den Bent M, van Putten W, Hooijkaas H, Vecht C
J Neurol 2002 Jun;249(6):745-53. doi: 10.1007/s00415-002-0706-4. PMID: 12111309
Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis.
Bernal F, Graus F, Pifarré A, Saiz A, Benyahia B, Ribalta T
Acta Neuropathol 2002 May;103(5):509-15. Epub 2002 Jan 31 doi: 10.1007/s00401-001-0498-0. PMID: 11935268
Limbic encephalitis and small cell lung cancer. Clinical and immunological features.
Alamowitch S, Graus F, Uchuya M, Reñé R, Bescansa E, Delattre JY
Brain 1997 Jun;120 ( Pt 6):923-8. doi: 10.1093/brain/120.6.923. PMID: 9217677

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