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Tic, Gestural

MedGen UID:
155652
•Concept ID:
C0751898
•
Sign or Symptom
Synonyms: Gestural Tic; Gestural Tics; Tics, Gestural

Professional guidelines

PubMed

Tourette syndrome: clinical features, pathophysiology, and treatment.
Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS
Lancet Neurol 2023 Feb;22(2):147-158. Epub 2022 Oct 28 doi: 10.1016/S1474-4422(22)00303-9. PMID: 36354027Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part III: pharmacological treatment.
Roessner V, Eichele H, Stern JS, Skov L, Rizzo R, Debes NM, Nagy P, Cavanna AE, Termine C, Ganos C, Münchau A, Szejko N, Cath D, Müller-Vahl KR, Verdellen C, Hartmann A, Rothenberger A, Hoekstra PJ, Plessen KJ
Eur Child Adolesc Psychiatry 2022 Mar;31(3):425-441. Epub 2021 Nov 10 doi: 10.1007/s00787-021-01899-z. PMID: 34757514Free PMC Article
Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence.
Krinzinger H, Hall CL, Groom MJ, Ansari MT, Banaschewski T, Buitelaar JK, Carucci S, Coghill D, Danckaerts M, Dittmann RW, Falissard B, Garas P, Inglis SK, Kovshoff H, Kochhar P, McCarthy S, Nagy P, Neubert A, Roberts S, Sayal K, Sonuga-Barke E, Wong ICK, Xia J, Zuddas A, Hollis C, Konrad K, Liddle EB; ADDUCE Consortium
Neurosci Biobehav Rev 2019 Dec;107:945-968. Epub 2019 Sep 20 doi: 10.1016/j.neubiorev.2019.09.023. PMID: 31545988

Recent clinical studies

Etiology

Ecopipam for Tourette Syndrome: A Randomized Trial.
Gilbert DL, Dubow JS, Cunniff TM, Wanaski SP, Atkinson SD, Mahableshwarkar AR
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-059574. PMID: 36628546
European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.
Szejko N, Robinson S, Hartmann A, Ganos C, Debes NM, Skov L, Haas M, Rizzo R, Stern J, Münchau A, Czernecki V, Dietrich A, Murphy TL, Martino D, Tarnok Z, Hedderly T, Müller-Vahl KR, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):383-402. Epub 2021 Oct 18 doi: 10.1007/s00787-021-01842-2. PMID: 34661764Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part II: psychological interventions.
Andrén P, Jakubovski E, Murphy TL, Woitecki K, Tarnok Z, Zimmerman-Brenner S, van de Griendt J, Debes NM, Viefhaus P, Robinson S, Roessner V, Ganos C, Szejko N, Müller-Vahl KR, Cath D, Hartmann A, Verdellen C
Eur Child Adolesc Psychiatry 2022 Mar;31(3):403-423. Epub 2021 Jul 27 doi: 10.1007/s00787-021-01845-z. PMID: 34313861Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders: summary statement.
Müller-Vahl KR, Szejko N, Verdellen C, Roessner V, Hoekstra PJ, Hartmann A, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):377-382. Epub 2021 Jul 10 doi: 10.1007/s00787-021-01832-4. PMID: 34244849Free PMC Article
Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments.
Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article

Diagnosis

Tourette syndrome: clinical features, pathophysiology, and treatment.
Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS
Lancet Neurol 2023 Feb;22(2):147-158. Epub 2022 Oct 28 doi: 10.1016/S1474-4422(22)00303-9. PMID: 36354027Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment.
Szejko N, Robinson S, Hartmann A, Ganos C, Debes NM, Skov L, Haas M, Rizzo R, Stern J, Münchau A, Czernecki V, Dietrich A, Murphy TL, Martino D, Tarnok Z, Hedderly T, Müller-Vahl KR, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):383-402. Epub 2021 Oct 18 doi: 10.1007/s00787-021-01842-2. PMID: 34661764Free PMC Article
European clinical guidelines for Tourette syndrome and other tic disorders: summary statement.
Müller-Vahl KR, Szejko N, Verdellen C, Roessner V, Hoekstra PJ, Hartmann A, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):377-382. Epub 2021 Jul 10 doi: 10.1007/s00787-021-01832-4. PMID: 34244849Free PMC Article
Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments.
Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article
Tics and Tourette Syndrome.
Singer HS
Continuum (Minneap Minn) 2019 Aug;25(4):936-958. doi: 10.1212/CON.0000000000000752. PMID: 31356288

Therapy

Ecopipam for Tourette Syndrome: A Randomized Trial.
Gilbert DL, Dubow JS, Cunniff TM, Wanaski SP, Atkinson SD, Mahableshwarkar AR
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-059574. PMID: 36628546
Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments.
Billnitzer A, Jankovic J
Neurotherapeutics 2020 Oct;17(4):1681-1693. doi: 10.1007/s13311-020-00914-6. PMID: 32856174Free PMC Article
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article
Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment.
Hirschtritt ME, Bloch MH, Mathews CA
JAMA 2017 Apr 4;317(13):1358-1367. doi: 10.1001/jama.2017.2200. PMID: 28384832
A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.
Damelin M, Bankovich A, Bernstein J, Lucas J, Chen L, Williams S, Park A, Aguilar J, Ernstoff E, Charati M, Dushin R, Aujay M, Lee C, Ramoth H, Milton M, Hampl J, Lazetic S, Pulito V, Rosfjord E, Sun Y, King L, Barletta F, Betts A, Guffroy M, Falahatpisheh H, O'Donnell CJ, Stull R, Pysz M, Escarpe P, Liu D, Foord O, Gerber HP, Sapra P, Dylla SJ
Sci Transl Med 2017 Jan 11;9(372) doi: 10.1126/scitranslmed.aag2611. PMID: 28077676

Prognosis

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome.
Mosley PE, Webb L, Suraev A, Hingston L, Turnbull T, Foster K, Ballard E, Gomes L, Mohan A, Sachdev PS, Kevin R, Gordon R, Benson M, McGregor IS
NEJM Evid 2023 Sep;2(9):EVIDoa2300012. Epub 2023 Jun 7 doi: 10.1056/EVIDoa2300012. PMID: 38320199
Tourette syndrome and other tic disorders of childhood.
Nilles C, Hartmann A, Roze E, Martino D, Pringsheim T
Handb Clin Neurol 2023;196:457-474. doi: 10.1016/B978-0-323-98817-9.00002-8. PMID: 37620085
Tourette syndrome: clinical features, pathophysiology, and treatment.
Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS
Lancet Neurol 2023 Feb;22(2):147-158. Epub 2022 Oct 28 doi: 10.1016/S1474-4422(22)00303-9. PMID: 36354027Free PMC Article
Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation.
Zhang HL, Chen P, Yan HX, Fu GB, Luo FF, Zhang J, Zhao SM, Zhai B, Yu JH, Chen L, Cui HS, Chen J, Huang S, Zeng J, Xu W, Wang HY, Liu J
Adv Sci (Weinh) 2022 Jul;9(20):e2103887. Epub 2022 Feb 20 doi: 10.1002/advs.202103887. PMID: 35187863Free PMC Article
Gilles de la Tourette syndrome.
Robertson MM, Eapen V, Singer HS, Martino D, Scharf JM, Paschou P, Roessner V, Woods DW, Hariz M, Mathews CA, Črnčec R, Leckman JF
Nat Rev Dis Primers 2017 Feb 2;3:16097. doi: 10.1038/nrdp.2016.97. PMID: 28150698

Clinical prediction guides

Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome.
Mosley PE, Webb L, Suraev A, Hingston L, Turnbull T, Foster K, Ballard E, Gomes L, Mohan A, Sachdev PS, Kevin R, Gordon R, Benson M, McGregor IS
NEJM Evid 2023 Sep;2(9):EVIDoa2300012. Epub 2023 Jun 7 doi: 10.1056/EVIDoa2300012. PMID: 38320199
Ecopipam for Tourette Syndrome: A Randomized Trial.
Gilbert DL, Dubow JS, Cunniff TM, Wanaski SP, Atkinson SD, Mahableshwarkar AR
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-059574. PMID: 36628546
Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis.
Farhat LC, Behling E, Landeros-Weisenberger A, Levine JLS, Macul Ferreira de Barros P, Wang Z, Bloch MH
Lancet Child Adolesc Health 2023 Feb;7(2):112-126. Epub 2022 Dec 14 doi: 10.1016/S2352-4642(22)00316-9. PMID: 36528030
Tourette syndrome: clinical features, pathophysiology, and treatment.
Johnson KA, Worbe Y, Foote KD, Butson CR, Gunduz A, Okun MS
Lancet Neurol 2023 Feb;22(2):147-158. Epub 2022 Oct 28 doi: 10.1016/S1474-4422(22)00303-9. PMID: 36354027Free PMC Article
Tics in patients with encephalitis.
Badenoch J, Searle T, Watson I, Cavanna AE
Neurol Sci 2021 Apr;42(4):1311-1323. Epub 2021 Jan 23 doi: 10.1007/s10072-021-05065-w. PMID: 33486621Free PMC Article

Recent systematic reviews

Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis.
Farhat LC, Behling E, Landeros-Weisenberger A, Levine JLS, Macul Ferreira de Barros P, Wang Z, Bloch MH
Lancet Child Adolesc Health 2023 Feb;7(2):112-126. Epub 2022 Dec 14 doi: 10.1016/S2352-4642(22)00316-9. PMID: 36528030
Using TikTok for public and youth mental health - A systematic review and content analysis.
McCashin D, Murphy CM
Clin Child Psychol Psychiatry 2023 Jan;28(1):279-306. Epub 2022 Jun 10 doi: 10.1177/13591045221106608. PMID: 35689365Free PMC Article
Tics in patients with encephalitis.
Badenoch J, Searle T, Watson I, Cavanna AE
Neurol Sci 2021 Apr;42(4):1311-1323. Epub 2021 Jan 23 doi: 10.1007/s10072-021-05065-w. PMID: 33486621Free PMC Article
Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders.
Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Müller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M
Neurology 2019 May 7;92(19):907-915. doi: 10.1212/WNL.0000000000007467. PMID: 31061209Free PMC Article
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders.
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article

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