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Intracranial vasospasm

MedGen UID:
199760
•Concept ID:
C0751895
•
Disease or Syndrome
Synonyms: Angiospasm, Intracranial; Angiospasms, Intracranial; Intracranial Angiospasm; Intracranial Angiospasms; Intracranial Vascular Spasm; Intracranial Vascular Spasms; Intracranial Vasospasm; Intracranial Vasospasms; Spasm, Intracranial Vascular; Spasms, Intracranial Vascular; Vascular Spasm, Intracranial; Vascular Spasms, Intracranial; Vasospasm, Intracranial; Vasospasms, Intracranial
 
Monarch Initiative: MONDO:0006812

Definition

Constriction of arteries in the skull due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and brain ischemia that may lead to hypoxic-ischemic brain injury (hypoxia-ischemia, brain). [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntracranial vasospasm

Professional guidelines

PubMed

Current Treatment Strategies for Intracranial Aneurysms: An Overview.
Zhao J, Lin H, Summers R, Yang M, Cousins BG, Tsui J
Angiology 2018 Jan;69(1):17-30. Epub 2017 Mar 30 doi: 10.1177/0003319717700503. PMID: 28355880Free PMC Article
Delayed cerebral ischaemia prevention and treatment after aneurysmal subarachnoid haemorrhage: a systematic review.
Veldeman M, Höllig A, Clusmann H, Stevanovic A, Rossaint R, Coburn M
Br J Anaesth 2016 Jul;117(1):17-40. Epub 2016 May 8 doi: 10.1093/bja/aew095. PMID: 27160932Free PMC Article
Review of aneurysmal subarachnoid hemorrhage--focus on treatment, anesthesia, cerebral vasospasm prophylaxis, and therapy.
Lin BF, Kuo CY, Wu ZF
Acta Anaesthesiol Taiwan 2014 Jun;52(2):77-84. Epub 2014 Jun 17 doi: 10.1016/j.aat.2014.04.005. PMID: 25016512

Recent clinical studies

Etiology

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Cerebral Vasospasm: Practical Review of Diagnosis and Management.
Romenskaya T, Longhitano Y, Piccolella F, Berger JM, Artico M, Taurone S, Maconi A, Saviano A, Caramuta M, Savioli G, Zanza C
Rev Recent Clin Trials 2023;18(1):12-18. doi: 10.2174/1574887117666220810121048. PMID: 35950252
Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings.
Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A
Radiol Med 2022 Sep;127(9):981-990. Epub 2022 Aug 6 doi: 10.1007/s11547-022-01532-2. PMID: 35932443Free PMC Article
Neuro-ultrasonography.
Hakimi R, Alexandrov AV, Garami Z
Neurol Clin 2020 Feb;38(1):215-229. doi: 10.1016/j.ncl.2019.09.006. PMID: 31761060
Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association.
Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P; American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology
Stroke 2012 Jun;43(6):1711-37. Epub 2012 May 3 doi: 10.1161/STR.0b013e3182587839. PMID: 22556195

Diagnosis

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Cerebral Vasospasm: Practical Review of Diagnosis and Management.
Romenskaya T, Longhitano Y, Piccolella F, Berger JM, Artico M, Taurone S, Maconi A, Saviano A, Caramuta M, Savioli G, Zanza C
Rev Recent Clin Trials 2023;18(1):12-18. doi: 10.2174/1574887117666220810121048. PMID: 35950252
A Review of the Management of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.
Li K, Barras CD, Chandra RV, Kok HK, Maingard JT, Carter NS, Russell JH, Lai L, Brooks M, Asadi H
World Neurosurg 2019 Jun;126:513-527. Epub 2019 Mar 18 doi: 10.1016/j.wneu.2019.03.083. PMID: 30898740
Cerebral Vasospasm: A Review.
Findlay JM, Nisar J, Darsaut T
Can J Neurol Sci 2016 Jan;43(1):15-32. Epub 2015 Sep 2 doi: 10.1017/cjn.2015.288. PMID: 26332908
Reversible cerebral vasoconstriction syndrome.
Ducros A
Lancet Neurol 2012 Oct;11(10):906-17. doi: 10.1016/S1474-4422(12)70135-7. PMID: 22995694

Therapy

Efficacy and Safety of Clazosentan After Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis.
Pontes JPM, Santos MDC, Gibram FC, Rodrigues NMV, Cavalcante-Neto JF, Barros ADM, Solla DJF
Neurosurgery 2023 Dec 1;93(6):1208-1219. Epub 2023 Jul 18 doi: 10.1227/neu.0000000000002601. PMID: 37462365
Clazosentan: First Approval.
Lee A
Drugs 2022 Apr;82(6):697-702. doi: 10.1007/s40265-022-01708-0. PMID: 35362854
Neuro-ultrasonography.
Hakimi R, Alexandrov AV, Garami Z
Neurol Clin 2020 Feb;38(1):215-229. doi: 10.1016/j.ncl.2019.09.006. PMID: 31761060
A Review of the Management of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.
Li K, Barras CD, Chandra RV, Kok HK, Maingard JT, Carter NS, Russell JH, Lai L, Brooks M, Asadi H
World Neurosurg 2019 Jun;126:513-527. Epub 2019 Mar 18 doi: 10.1016/j.wneu.2019.03.083. PMID: 30898740
Cerebral Vasospasm: A Review.
Findlay JM, Nisar J, Darsaut T
Can J Neurol Sci 2016 Jan;43(1):15-32. Epub 2015 Sep 2 doi: 10.1017/cjn.2015.288. PMID: 26332908

Prognosis

Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm.
Hu Z, Deng X, Zhou S, Zhou C, Shen M, Gao X, Huang Y
Fluids Barriers CNS 2023 Nov 4;20(1):81. doi: 10.1186/s12987-023-00483-8. PMID: 37925414Free PMC Article
Headache: Headache Emergencies.
Walling A
FP Essent 2018 Oct;473:21-25. PMID: 30346681
Reversible cerebral vasoconstriction syndrome.
Ducros A
Lancet Neurol 2012 Oct;11(10):906-17. doi: 10.1016/S1474-4422(12)70135-7. PMID: 22995694
Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association.
Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P; American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology
Stroke 2012 Jun;43(6):1711-37. Epub 2012 May 3 doi: 10.1161/STR.0b013e3182587839. PMID: 22556195
Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference.
Diringer MN, Bleck TP, Claude Hemphill J 3rd, Menon D, Shutter L, Vespa P, Bruder N, Connolly ES Jr, Citerio G, Gress D, Hänggi D, Hoh BL, Lanzino G, Le Roux P, Rabinstein A, Schmutzhard E, Stocchetti N, Suarez JI, Treggiari M, Tseng MY, Vergouwen MD, Wolf S, Zipfel G; Neurocritical Care Society
Neurocrit Care 2011 Sep;15(2):211-40. doi: 10.1007/s12028-011-9605-9. PMID: 21773873

Clinical prediction guides

Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: a multicenter retrospective cohort study.
Muraoka S, Asai T, Fukui T, Ota S, Shimato S, Koketsu N, Nishizawa T, Araki Y, Saito R
Neurosurg Rev 2023 Aug 9;46(1):195. doi: 10.1007/s10143-023-02104-2. PMID: 37555872
Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Effects of clazosentan on cerebral vasospasm-related morbidity and all-cause mortality after aneurysmal subarachnoid hemorrhage: two randomized phase 3 trials in Japanese patients.
Endo H, Hagihara Y, Kimura N, Takizawa K, Niizuma K, Togo O, Tominaga T
J Neurosurg 2022 Dec 1;137(6):1707-1717. Epub 2022 Apr 1 doi: 10.3171/2022.2.JNS212914. PMID: 35364589
Milrinone and homeostasis to treat cerebral vasospasm associated with subarachnoid hemorrhage: the Montreal Neurological Hospital protocol.
Lannes M, Teitelbaum J, del Pilar Cortés M, Cardoso M, Angle M
Neurocrit Care 2012 Jun;16(3):354-62. doi: 10.1007/s12028-012-9701-5. PMID: 22528278
Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale.
Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, MacDonald RL, Mayer SA
Neurosurgery 2006 Jul;59(1):21-7; discussion 21-7. doi: 10.1227/01.neu.0000243277.86222.6c. PMID: 16823296

Recent systematic reviews

Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage.
Spears WE, Greer DM, Nguyen TN
Stroke 2023 Oct;54(10):2708-2712. Epub 2023 Aug 15 doi: 10.1161/STROKEAHA.123.043541. PMID: 37581267
Efficacy and Safety of Clazosentan After Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis.
Pontes JPM, Santos MDC, Gibram FC, Rodrigues NMV, Cavalcante-Neto JF, Barros ADM, Solla DJF
Neurosurgery 2023 Dec 1;93(6):1208-1219. Epub 2023 Jul 18 doi: 10.1227/neu.0000000000002601. PMID: 37462365
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Dayyani M, Sadeghirad B, Grotta JC, Zabihyan S, Ahmadvand S, Wang Y, Guyatt GH, Amin-Hanjani S
Stroke 2022 Jun;53(6):1993-2005. Epub 2022 Mar 31 doi: 10.1161/STROKEAHA.121.035699. PMID: 35354302
Systematic Review of Intrathecal Nicardipine for the Treatment of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.
Hafeez S, Grandhi R
Neurocrit Care 2019 Oct;31(2):399-405. doi: 10.1007/s12028-018-0659-9. PMID: 30607826

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