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Minimally conscious state

MedGen UID:
155616
Concept ID:
C0751699
Disease or Syndrome
Synonyms: Minimally Conscious State; Minimally Conscious States; State, Minimally Conscious; States, Minimally Conscious
SNOMED CT: Minimally conscious state (709012003)

Professional guidelines

PubMed

Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):450-460. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005926. PMID: 30089618Free PMC Article
Hodelín-Tablada R
MEDICC Rev 2016 Oct;18(4):43-46. doi: 10.37757/MR2016.V18.N4.9. PMID: 27829654

Recent clinical studies

Etiology

Llorens R, Ippoliti C, Navarro MD, Colomer C, Maza A, Goizueta S, Olaya J, Moliner B, Ferri J, Noé E
Ann Clin Transl Neurol 2024 Mar;11(3):719-728. Epub 2024 Feb 17 doi: 10.1002/acn3.51993. PMID: 38366789Free PMC Article
Hernández M, Calderón G, Tejada PC, Duk N
Andes Pediatr 2021 Feb;92(1):15-24. Epub 2021 Feb 22 doi: 10.32641/andespediatr.v92i1.2502. PMID: 34106179
Aubinet C, Larroque SK, Heine L, Martial C, Majerus S, Laureys S, Di Perri C
Hum Brain Mapp 2018 Nov;39(11):4519-4532. Epub 2018 Jul 4 doi: 10.1002/hbm.24303. PMID: 29972267Free PMC Article
Peterson A, Cruse D, Naci L, Weijer C, Owen AM
Neuroimage Clin 2015;7:588-97. Epub 2015 Feb 20 doi: 10.1016/j.nicl.2015.02.008. PMID: 25844313Free PMC Article
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973

Diagnosis

Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Overbeek BUH, Eilander HJ, Lavrijsen JCM, Koopmans RTCM
J Neurol 2018 Sep;265(9):1957-1975. Epub 2018 Feb 28 doi: 10.1007/s00415-018-8788-9. PMID: 29492651Free PMC Article
Chatelle C, Thibaut A, Whyte J, De Val MD, Laureys S, Schnakers C
Brain Inj 2014;28(9):1202-8. doi: 10.3109/02699052.2014.920518. PMID: 25099024
Giacino JT, Kalmar K, Whyte J
Arch Phys Med Rehabil 2004 Dec;85(12):2020-9. doi: 10.1016/j.apmr.2004.02.033. PMID: 15605342
Laureys S, Owen AM, Schiff ND
Lancet Neurol 2004 Sep;3(9):537-46. doi: 10.1016/S1474-4422(04)00852-X. PMID: 15324722

Therapy

Amiri M, Fisher PM, Raimondo F, Sidaros A, Cacic Hribljan M, Othman MH, Zibrandtsen I, Albrechtsen SS, Bergdal O, Hansen AE, Hassager C, Højgaard JLS, Jakobsen EW, Jensen HR, Møller J, Nersesjan V, Nikolic M, Olsen MH, Sigurdsson ST, Sitt JD, Sølling C, Welling KL, Willumsen LM, Hauerberg J, Larsen VA, Fabricius M, Knudsen GM, Kjaergaard J, Møller K, Kondziella D
Brain 2023 Jan 5;146(1):50-64. doi: 10.1093/brain/awac335. PMID: 36097353Free PMC Article
Noormandi A, Shahrokhi M, Khalili H
Expert Rev Clin Pharmacol 2017 Sep;10(9):983-992. Epub 2017 Jul 10 doi: 10.1080/17512433.2017.1347502. PMID: 28649875
Geri G, Mongardon N, Daviaud F, Empana JP, Dumas F, Cariou A
Ann Fr Anesth Reanim 2014 Feb;33(2):98-101. Epub 2013 Dec 20 doi: 10.1016/j.annfar.2013.11.003. PMID: 24361281
Bodart O, Laureys S, Gosseries O
Semin Neurol 2013 Apr;33(2):83-90. Epub 2013 Jul 25 doi: 10.1055/s-0033-1348965. PMID: 23888393
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973

Prognosis

Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):450-460. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005926. PMID: 30089618Free PMC Article
Sharma K, Stevens RD
Handb Clin Neurol 2017;140:379-395. doi: 10.1016/B978-0-444-63600-3.00021-0. PMID: 28187811
Chatelle C, Thibaut A, Whyte J, De Val MD, Laureys S, Schnakers C
Brain Inj 2014;28(9):1202-8. doi: 10.3109/02699052.2014.920518. PMID: 25099024
Laureys S, Owen AM, Schiff ND
Lancet Neurol 2004 Sep;3(9):537-46. doi: 10.1016/S1474-4422(04)00852-X. PMID: 15324722

Clinical prediction guides

Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Aubinet C, Larroque SK, Heine L, Martial C, Majerus S, Laureys S, Di Perri C
Hum Brain Mapp 2018 Nov;39(11):4519-4532. Epub 2018 Jul 4 doi: 10.1002/hbm.24303. PMID: 29972267Free PMC Article
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973
Giacino JT, Kalmar K, Whyte J
Arch Phys Med Rehabil 2004 Dec;85(12):2020-9. doi: 10.1016/j.apmr.2004.02.033. PMID: 15605342

Recent systematic reviews

Wu Y, Xu YY, Deng H, Zhang W, Zhang SX, Li JM, Xiong BT, Xiao LL, Li DH, Ren ZY, Qin YF, Yang RQ, Wang W
Neurosurg Rev 2023 Aug 14;46(1):200. doi: 10.1007/s10143-023-02105-1. PMID: 37578633
Magliacano A, De Bellis F, Panico F, Sagliano L, Trojano L, Sandroni C, Estraneo A
Eur J Neurol 2023 Dec;30(12):3913-3927. Epub 2023 Jun 8 doi: 10.1111/ene.15899. PMID: 37246500
Lancioni GE, Singh NN, O'Reilly MF, Sigafoos J, Desideri L
Disabil Rehabil 2022 Dec;44(24):7677-7692. Epub 2021 Oct 6 doi: 10.1080/09638288.2021.1985634. PMID: 34613851
van Erp WS, Lavrijsen JC, van de Laar FA, Vos PE, Laureys S, Koopmans RT
Eur J Neurol 2014 Nov;21(11):1361-8. Epub 2014 Jul 21 doi: 10.1111/ene.12483. PMID: 25039901
Pisa FE, Biasutti E, Drigo D, Barbone F
J Head Trauma Rehabil 2014 Jul-Aug;29(4):E23-30. doi: 10.1097/HTR.0b013e3182a4469f. PMID: 24052091

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