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Minimally conscious state

MedGen UID:
155616
Concept ID:
C0751699
Disease or Syndrome
Synonyms: Minimally Conscious State; Minimally Conscious States; State, Minimally Conscious; States, Minimally Conscious
SNOMED CT: Minimally conscious state (709012003)

Professional guidelines

PubMed

Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):450-460. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005926. PMID: 30089618Free PMC Article
Rosenbaum AM, Giacino JT
Handb Clin Neurol 2015;127:395-410. doi: 10.1016/B978-0-444-52892-6.00025-8. PMID: 25702230

Recent clinical studies

Etiology

Bodien YG, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh JE, Kamau E, Lawrence PK, Lupson VC, Meydan A, Rohaut B, Sanders WR, Sitt JD, Soddu A, Valente M, Velazquez A, Voss HU, Vrosgou A, Claassen J, Edlow BL, Fins JJ, Gosseries O, Laureys S, Menon D, Naccache L, Owen AM, Pickard J, Stamatakis EA, Thibaut A, Victor JD, Giacino JT, Bagiella E, Schiff ND
N Engl J Med 2024 Aug 15;391(7):598-608. doi: 10.1056/NEJMoa2400645. PMID: 39141852
Thibaut A, Fregni F, Estraneo A, Fiorenza S, Noe E, Llorens R, Ferri J, Formisano R, Morone G, Bender A, Rosenfelder M, Lamberti G, Kodratyeva E, Kondratyev S, Legostaeva L, Suponeva N, Krewer C, Müller F, Dardenne N, Jedidi H, Laureys S, Gosseries O, Lejeune N, Martens G; IBIA DOC-SIG
Eur J Neurol 2023 Oct;30(10):3016-3031. Epub 2023 Jul 28 doi: 10.1111/ene.15974. PMID: 37515394
Vitello MM, Szymkowicz E, Laureys S, Alnagger N, Gosseries O, Thibaut A
Dev Med Child Neurol 2022 Jun;64(6):681-690. Epub 2022 Jan 28 doi: 10.1111/dmcn.15150. PMID: 35089596
Formisano R, Zasler ND
J Head Trauma Rehabil 2014 Jul-Aug;29(4):387-90. doi: 10.1097/HTR.0000000000000027. PMID: 24695262
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973

Diagnosis

Young MJ, Edlow BL, Bodien YG
NeuroRehabilitation 2024;54(1):23-42. doi: 10.3233/NRE-230123. PMID: 38217619Free PMC Article
Golden K, Bodien YG, Giacino JT
Phys Med Rehabil Clin N Am 2024 Feb;35(1):15-33. Epub 2023 Jul 27 doi: 10.1016/j.pmr.2023.06.011. PMID: 37993185Free PMC Article
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Formisano R, Zasler ND
J Head Trauma Rehabil 2014 Jul-Aug;29(4):387-90. doi: 10.1097/HTR.0000000000000027. PMID: 24695262
Laureys S, Owen AM, Schiff ND
Lancet Neurol 2004 Sep;3(9):537-46. doi: 10.1016/S1474-4422(04)00852-X. PMID: 15324722

Therapy

Thibaut A, Fregni F, Estraneo A, Fiorenza S, Noe E, Llorens R, Ferri J, Formisano R, Morone G, Bender A, Rosenfelder M, Lamberti G, Kodratyeva E, Kondratyev S, Legostaeva L, Suponeva N, Krewer C, Müller F, Dardenne N, Jedidi H, Laureys S, Gosseries O, Lejeune N, Martens G; IBIA DOC-SIG
Eur J Neurol 2023 Oct;30(10):3016-3031. Epub 2023 Jul 28 doi: 10.1111/ene.15974. PMID: 37515394
Amiri M, Fisher PM, Raimondo F, Sidaros A, Cacic Hribljan M, Othman MH, Zibrandtsen I, Albrechtsen SS, Bergdal O, Hansen AE, Hassager C, Højgaard JLS, Jakobsen EW, Jensen HR, Møller J, Nersesjan V, Nikolic M, Olsen MH, Sigurdsson ST, Sitt JD, Sølling C, Welling KL, Willumsen LM, Hauerberg J, Larsen VA, Fabricius M, Knudsen GM, Kjaergaard J, Møller K, Kondziella D
Brain 2023 Jan 5;146(1):50-64. doi: 10.1093/brain/awac335. PMID: 36097353Free PMC Article
Tucker C, Sandhu K
Neurocrit Care 2016 Jun;24(3):488-93. doi: 10.1007/s12028-015-0227-5. PMID: 26718349
Formisano R, Zasler ND
J Head Trauma Rehabil 2014 Jul-Aug;29(4):387-90. doi: 10.1097/HTR.0000000000000027. PMID: 24695262
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973

Prognosis

Young MJ, Edlow BL, Bodien YG
NeuroRehabilitation 2024;54(1):23-42. doi: 10.3233/NRE-230123. PMID: 38217619Free PMC Article
Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Giacino JT, Katz DI, Schiff ND, Whyte J, Ashman EJ, Ashwal S, Barbano R, Hammond FM, Laureys S, Ling GSF, Nakase-Richardson R, Seel RT, Yablon S, Getchius TSD, Gronseth GS, Armstrong MJ
Neurology 2018 Sep 4;91(10):450-460. Epub 2018 Aug 8 doi: 10.1212/WNL.0000000000005926. PMID: 30089618Free PMC Article
Formisano R, Zasler ND
J Head Trauma Rehabil 2014 Jul-Aug;29(4):387-90. doi: 10.1097/HTR.0000000000000027. PMID: 24695262
Laureys S, Owen AM, Schiff ND
Lancet Neurol 2004 Sep;3(9):537-46. doi: 10.1016/S1474-4422(04)00852-X. PMID: 15324722

Clinical prediction guides

Bodien YG, Barra A, Temkin NR, Barber J, Foreman B, Vassar M, Robertson C, Taylor SR, Markowitz AJ, Manley GT, Giacino JT, Edlow BL; TRACK-TBI Investigators
J Neurotrauma 2021 Dec;38(23):3295-3305. doi: 10.1089/neu.2021.0199. PMID: 34605668Free PMC Article
Kondziella D, Bender A, Diserens K, van Erp W, Estraneo A, Formisano R, Laureys S, Naccache L, Ozturk S, Rohaut B, Sitt JD, Stender J, Tiainen M, Rossetti AO, Gosseries O, Chatelle C; EAN Panel on Coma, Disorders of Consciousness
Eur J Neurol 2020 May;27(5):741-756. Epub 2020 Feb 23 doi: 10.1111/ene.14151. PMID: 32090418
Sharma K, Stevens RD
Handb Clin Neurol 2017;140:379-395. doi: 10.1016/B978-0-444-63600-3.00021-0. PMID: 28187811
Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M
N Engl J Med 2012 Mar 1;366(9):819-26. doi: 10.1056/NEJMoa1102609. PMID: 22375973
Giacino JT, Kalmar K, Whyte J
Arch Phys Med Rehabil 2004 Dec;85(12):2020-9. doi: 10.1016/j.apmr.2004.02.033. PMID: 15605342

Recent systematic reviews

Lancioni GE, Singh NN, O'Reilly MF, Sigafoos J, Desideri L
Disabil Rehabil 2022 Dec;44(24):7677-7692. Epub 2021 Oct 6 doi: 10.1080/09638288.2021.1985634. PMID: 34613851
Bai Y, Lin Y, Ziemann U
J Neurol 2021 Nov;268(11):4033-4065. Epub 2020 Sep 11 doi: 10.1007/s00415-020-10095-z. PMID: 32915309Free PMC Article
Bender A, Jox RJ, Grill E, Straube A, Lulé D
Dtsch Arztebl Int 2015 Apr 3;112(14):235-42. doi: 10.3238/arztebl.2015.0235. PMID: 25891806Free PMC Article
Pisa FE, Biasutti E, Drigo D, Barbone F
J Head Trauma Rehabil 2014 Jul-Aug;29(4):E23-30. doi: 10.1097/HTR.0b013e3182a4469f. PMID: 24052091
Georgiopoulos M, Katsakiori P, Kefalopoulou Z, Ellul J, Chroni E, Constantoyannis C
Stereotact Funct Neurosurg 2010;88(4):199-207. Epub 2010 May 12 doi: 10.1159/000314354. PMID: 20460949

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