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Malignant squamous cell neoplasm

MedGen UID:
148367
•Concept ID:
C0751688
•
Neoplastic Process
Synonyms: Cancer, Squamous Cell; Cancers, Squamous Cell; Cell Cancer, Squamous; Cell Cancers, Squamous; Squamous Cell Cancer; Squamous Cell Cancers
SNOMED CT: Malignant squamous tumor (1255006006); Malignant squamous cell neoplasm (1255006006)

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors.
Marçon CR, Maia M
An Bras Dermatol 2019 Sep-Oct;94(5):503-520. Epub 2019 Sep 30 doi: 10.1016/j.abd.2019.09.023. PMID: 31777350Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article
Malignant tumors of the penis.
Brady KL, Mercurio MG, Brown MD
Dermatol Surg 2013 Apr;39(4):527-47. Epub 2012 Nov 16 doi: 10.1111/dsu.12029. PMID: 23164051
Oral cancer: clinical features.
Bagan J, Sarrion G, Jimenez Y
Oral Oncol 2010 Jun;46(6):414-7. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.03.009. PMID: 20400366

Diagnosis

Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis.
Bugshan A, Farooq I
F1000Res 2020;9:229. Epub 2020 Apr 2 doi: 10.12688/f1000research.22941.1. PMID: 32399208Free PMC Article
Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131
Oral cancer: clinical features.
Bagan J, Sarrion G, Jimenez Y
Oral Oncol 2010 Jun;46(6):414-7. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.03.009. PMID: 20400366

Therapy

Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Essentials of oral cancer.
Rivera C
Int J Clin Exp Pathol 2015;8(9):11884-94. Epub 2015 Sep 1 PMID: 26617944Free PMC Article
Human Papillomavirus-Negative Pharyngeal Cancer.
Dillon MT, Harrington KJ
J Clin Oncol 2015 Oct 10;33(29):3251-61. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.60.7804. PMID: 26351347
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.
Pignon JP, le Maître A, Maillard E, Bourhis J; MACH-NC Collaborative Group
Radiother Oncol 2009 Jul;92(1):4-14. Epub 2009 May 14 doi: 10.1016/j.radonc.2009.04.014. PMID: 19446902
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Prognosis

Management of Subglottic Cancer.
Mann H, Seligman K, Colwell N, Burr A, Glazer TA
Otolaryngol Clin North Am 2023 Apr;56(2):305-312. doi: 10.1016/j.otc.2022.11.001. PMID: 37030943
Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Postoperative radiation therapy of pT2-3N0M0 esophageal carcinoma-a review.
Luo Y, Wang X, Yu J, Zhang B, Li M
Tumour Biol 2016 Nov;37(11):14443-14450. Epub 2016 Sep 18 doi: 10.1007/s13277-016-5373-7. PMID: 27639386
Cutaneous Malignant Neoplasms in Hematopoietic Cell Transplant Recipients: A Systematic Review.
DePry JL, Vyas R, Lazarus HM, Caimi PF, Gerstenblith MR, Bordeaux JS
JAMA Dermatol 2015 Jul;151(7):775-82. doi: 10.1001/jamadermatol.2015.121. PMID: 25902409
Periocular squamous cell carcinoma.
Limawararut V, Leibovitch I, Sullivan T, Selva D
Clin Exp Ophthalmol 2007 Mar;35(2):174-85. doi: 10.1111/j.1442-9071.2006.01411.x. PMID: 17362462

Clinical prediction guides

Actinic keratosis metrics.
Burstein SE, Maibach H
Arch Dermatol Res 2024 Aug 20;316(8):543. doi: 10.1007/s00403-024-03305-5. PMID: 39162820Free PMC Article
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma: A Review.
Chu CS, Lee NP, Ho JWK, Choi SW, Thomson PJ
JAMA Otolaryngol Head Neck Surg 2021 Oct 1;147(10):893-900. doi: 10.1001/jamaoto.2021.2028. PMID: 34410314
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell 2017 Dec 14;171(7):1611-1624.e24. Epub 2017 Nov 30 doi: 10.1016/j.cell.2017.10.044. PMID: 29198524Free PMC Article
A Malignant Mimic.
Shergill S, Smyrk TC, Sweetser S
Gastroenterology 2017 Apr;152(5):953-955. Epub 2017 Mar 1 doi: 10.1053/j.gastro.2016.11.015. PMID: 28259718
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article

Recent systematic reviews

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.
Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780Free PMC Article
Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
Mainville L, Smilga AS, Fortin PR
J Cutan Med Surg 2022 May-Jun;26(3):297-308. Epub 2022 Feb 8 doi: 10.1177/12034754221078201. PMID: 35134311Free PMC Article
Squamous cell carcinoma complicating chronic osteomyelitis: A systematic review and case series.
Corrigan RA, Barlow G, Hartley C, McNally M
Surgeon 2022 Dec;20(6):e322-e337. Epub 2021 Dec 28 doi: 10.1016/j.surge.2021.12.003. PMID: 34969605
Autoimmune disease and oral squamous cell carcinoma: A systematic review.
Pillai A, Adilbay D, Matsoukas K, Ganly I, Patel SG
J Oral Pathol Med 2021 Oct;50(9):855-863. Epub 2021 Jul 12 doi: 10.1111/jop.13218. PMID: 34145639Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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