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Tetraplegic spinal paralysis

MedGen UID:
199662
•Concept ID:
C0751461
•
Disease or Syndrome
Synonym: Paralysis, Spinal, Quadriplegic
SNOMED CT: Quadriplegic spinal paralysis (371120001); Tetraplegic spinal paralysis (371120001)

Professional guidelines

PubMed

Exercise and sports science Australia (ESSA) position statement on exercise and spinal cord injury.
Tweedy SM, Beckman EM, Geraghty TJ, Theisen D, Perret C, Harvey LA, Vanlandewijck YC
J Sci Med Sport 2017 Feb;20(2):108-115. Epub 2016 Mar 9 doi: 10.1016/j.jsams.2016.02.001. PMID: 27185457
Tetraplegia Management Update.
Fridén J, Gohritz A
J Hand Surg Am 2015 Dec;40(12):2489-500. doi: 10.1016/j.jhsa.2015.06.003. PMID: 26537454
Spasticity: pathophysiology, evaluation and management.
Kheder A, Nair KP
Pract Neurol 2012 Oct;12(5):289-98. doi: 10.1136/practneurol-2011-000155. PMID: 22976059

Recent clinical studies

Etiology

Current Concepts in Elbow Extension Reconstruction for the Tetraplegic Patient.
Zlotolow DA, Kripke LA, Kozin SH
J Am Acad Orthop Surg 2023 Mar 1;31(5):221-228. doi: 10.5435/JAAOS-D-22-00348. PMID: 36745692
Acute non-traumatic tetraparesis - Differential diagnosis.
Oliveira R, Ramalho Rocha F, Teodoro T, Oliveira Santos M
J Clin Neurosci 2021 May;87:116-124. Epub 2021 Mar 20 doi: 10.1016/j.jocn.2021.02.024. PMID: 33863518
Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.
Boswell-Ruys CL, Lewis CRH, Wijeysuriya NS, McBain RA, Lee BB, McKenzie DK, Gandevia SC, Butler JE
Thorax 2020 Mar;75(3):279-288. Epub 2020 Jan 14 doi: 10.1136/thoraxjnl-2019-213917. PMID: 31937553
Tetraplegia Management Update.
Fridén J, Gohritz A
J Hand Surg Am 2015 Dec;40(12):2489-500. doi: 10.1016/j.jhsa.2015.06.003. PMID: 26537454
Tetraplegia.
McDowell CL, Rago TA, Gonzalez SM
Hand Clin 1989 Aug;5(3):343-8. PMID: 2670962

Diagnosis

Grasp and Release Test for Tetraplegic Hand Assessment: an update of the Grasp and Release Test.
Dunn JA, Wangdell J, Bryden A
Spinal Cord 2023 Aug;61(8):466-468. Epub 2023 Jul 4 doi: 10.1038/s41393-023-00907-0. PMID: 37402892Free PMC Article
Locked-In Syndrome #303.
Maiser S, Kabir A, Sabsevitz D, Peltier W
J Palliat Med 2016 Apr;19(4):460-1. Epub 2016 Mar 7 doi: 10.1089/jpm.2016.0016. PMID: 26950052
Addendum.
Kübler A, Holz E, Botrel L
Brain 2013 Jun;136(Pt 6):2005-6. doi: 10.1093/brain/awt156. PMID: 23739918
Locked-in syndrome.
Cardwell MS
Tex Med 2013 Feb 1;109(2):e1. PMID: 23378122
Spasticity: pathophysiology, evaluation and management.
Kheder A, Nair KP
Pract Neurol 2012 Oct;12(5):289-98. doi: 10.1136/practneurol-2011-000155. PMID: 22976059

Therapy

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.
Moritz C, Field-Fote EC, Tefertiller C, van Nes I, Trumbower R, Kalsi-Ryan S, Purcell M, Janssen TWJ, Krassioukov A, Morse LR, Zhao KD, Guest J, Marino RJ, Murray LM, Wecht JM, Rieger M, Pradarelli J, Turner A, D'Amico J, Squair JW, Courtine G
Nat Med 2024 May;30(5):1276-1283. Epub 2024 May 20 doi: 10.1038/s41591-024-02940-9. PMID: 38769431Free PMC Article
Quadriparesis Due to Delayed Tension Pneumoventricle.
Maramattom BV
Neurologist 2021 Nov 26;27(2):74-78. doi: 10.1097/NRL.0000000000000363. PMID: 34842575
Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.
Boswell-Ruys CL, Lewis CRH, Wijeysuriya NS, McBain RA, Lee BB, McKenzie DK, Gandevia SC, Butler JE
Thorax 2020 Mar;75(3):279-288. Epub 2020 Jan 14 doi: 10.1136/thoraxjnl-2019-213917. PMID: 31937553
Rituximab in refractory chronic inflammatory demyelinating polyneuropathy.
Muley SA, Jacobsen B, Parry G, Usman U, Ortega E, Walk D, Allen J, Pasnoor M, Varon M, Dimachkie MM
Muscle Nerve 2020 May;61(5):575-579. Epub 2020 Jan 21 doi: 10.1002/mus.26804. PMID: 31922613
Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration.
Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF
Lancet 2017 May 6;389(10081):1821-1830. Epub 2017 Mar 28 doi: 10.1016/S0140-6736(17)30601-3. PMID: 28363483Free PMC Article

Prognosis

Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.
Boswell-Ruys CL, Lewis CRH, Wijeysuriya NS, McBain RA, Lee BB, McKenzie DK, Gandevia SC, Butler JE
Thorax 2020 Mar;75(3):279-288. Epub 2020 Jan 14 doi: 10.1136/thoraxjnl-2019-213917. PMID: 31937553
Locked-in syndrome.
Cardwell MS
Tex Med 2013 Feb 1;109(2):e1. PMID: 23378122
Locked-in syndrome.
Smith E, Delargy M
BMJ 2005 Feb 19;330(7488):406-9. doi: 10.1136/bmj.330.7488.406. PMID: 15718541Free PMC Article
Atypical hangman's fractures.
Starr JK, Eismont FJ
Spine (Phila Pa 1976) 1993 Oct 15;18(14):1954-7. doi: 10.1097/00007632-199310001-00005. PMID: 8272942
Traumatic occipitoatlantal dislocations.
Dickman CA, Papadopoulos SM, Sonntag VK, Spetzler RF, Rekate HL, Drabier J
J Spinal Disord 1993 Aug;6(4):300-13. doi: 10.1097/00002517-199306040-00004. PMID: 8219544

Clinical prediction guides

Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia.
Javeed S, Dibble CF, Greenberg JK, Zhang JK, Khalifeh JM, Park Y, Wilson TJ, Zager EL, Faraji AH, Mahan MA, Yang LJ, Midha R, Juknis N, Ray WZ
JAMA Netw Open 2022 Nov 1;5(11):e2243890. doi: 10.1001/jamanetworkopen.2022.43890. PMID: 36441549Free PMC Article
Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation in Humans with Tetraplegia.
Benavides FD, Jo HJ, Lundell H, Edgerton VR, Gerasimenko Y, Perez MA
J Neurosci 2020 Mar 25;40(13):2633-2643. Epub 2020 Jan 29 doi: 10.1523/JNEUROSCI.2374-19.2020. PMID: 31996455Free PMC Article
Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.
Boswell-Ruys CL, Lewis CRH, Wijeysuriya NS, McBain RA, Lee BB, McKenzie DK, Gandevia SC, Butler JE
Thorax 2020 Mar;75(3):279-288. Epub 2020 Jan 14 doi: 10.1136/thoraxjnl-2019-213917. PMID: 31937553
Rituximab in refractory chronic inflammatory demyelinating polyneuropathy.
Muley SA, Jacobsen B, Parry G, Usman U, Ortega E, Walk D, Allen J, Pasnoor M, Varon M, Dimachkie MM
Muscle Nerve 2020 May;61(5):575-579. Epub 2020 Jan 21 doi: 10.1002/mus.26804. PMID: 31922613
Periodic limb movements in tetraplegia.
Peters AEJ, van Silfhout L, Graco M, Schembri R, Thijssen D, Berlowitz DJ
J Spinal Cord Med 2018 May;41(3):318-325. Epub 2017 May 2 doi: 10.1080/10790268.2017.1320874. PMID: 28464758Free PMC Article

Recent systematic reviews

Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review.
Mofatteh M, Mashayekhi MS, Arfaie S, Chen Y, Malhotra AK, Skandalakis GP, Alvi MA, Afshari FT, Meshkat S, Lin F, Abdulla E, Anand A, Liao X, McIntyre RS, Santaguida C, Weber MH, Fehlings MG
World Neurosurg 2024 Apr;184:267-282.e5. Epub 2023 Dec 23 doi: 10.1016/j.wneu.2023.12.092. PMID: 38143027
Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Intramedullary cervical spinal cord teratoma.
Wang L, Li T, Gong M, Xing F, Li L, Xiao R, Guan Q
Medicine (Baltimore) 2020 May;99(18):e20107. doi: 10.1097/MD.0000000000020107. PMID: 32358400Free PMC Article
Intracavernous Injections in Spinal Cord Injured Men With Erectile Dysfunction, a Systematic Review and Meta-Analysis.
Chochina L, Naudet F, Chéhensse C, Manunta A, Damphousse M, Bonan I, Giuliano F
Sex Med Rev 2016 Jul;4(3):257-269. Epub 2016 Mar 29 doi: 10.1016/j.sxmr.2016.02.005. PMID: 27871959
Bisphosphonate use in acute and chronic spinal cord injury: a systematic review.
Bryson JE, Gourlay ML
J Spinal Cord Med 2009;32(3):215-25. doi: 10.1080/10790268.2009.11760776. PMID: 19810623Free PMC Article

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