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Hypothalamic dysfunction

MedGen UID:
155833
Concept ID:
C0751230
Disease or Syndrome
Synonyms: Dysfunction Syndrome, Hypothalamic; Dysfunction Syndromes, Hypothalamic; Hypothalamic Dysfunction Syndrome; Hypothalamic Dysfunction Syndromes; Syndrome, Hypothalamic Dysfunction; Syndromes, Hypothalamic Dysfunction
SNOMED CT: Hypothalamic syndrome (111568001); Hypothalamic dysfunction (111568001)
 
Monarch Initiative: MONDO:0043101

Definition

Hypothalamic dysfunction refers to a condition in which the hypothalamus is not working properly. The hypothalamus produces hormones that control body temperature, hunger, moods, release of hormones from many glands such as the pituitary gland, sex drive, sleep, and thirst. The signs and symptoms patients have vary depending on the hormones missing. A number of different causes including anorexia, bleeding, genetic disorder, tumors, and more have been linked to hypothalamic dysfunction. Treatment depends on the cause of the hypothalamic dysfunction. [from MONDO]

Professional guidelines

PubMed

Van Schaik J, Schouten-van Meeteren AYN, Vos-Kerkhof E, Janssens GO, Porro GL, Fiocco M, Bakker B, Tissing WJE, Hoving EW, van Santen HM
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Zhao C, Zhou Z, Zhang Y, Qi X, Wang X, Lin D, Liu H, Wang Y, Weng C, Chen J, Hu W, Liao L, Lin Z
World Neurosurg 2022 Sep;165:e148-e158. Epub 2022 May 31 doi: 10.1016/j.wneu.2022.05.115. PMID: 35660482
Butler MG, Manzardo AM, Forster JL
Curr Pediatr Rev 2016;12(2):136-66. doi: 10.2174/1573396312666151123115250. PMID: 26592417Free PMC Article

Recent clinical studies

Etiology

Pascual JM, Prieto R, Rosdolsky M
Handb Clin Neurol 2021;181:75-115. doi: 10.1016/B978-0-12-820683-6.00007-5. PMID: 34238481
Alves C, Franco RR
Arch Endocrinol Metab 2020 May-Jun;64(3):223-234. doi: 10.20945/2359-3997000000248. PMID: 32555988Free PMC Article
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Huhmann K
Clin Ther 2020 Mar;42(3):401-407. Epub 2020 Mar 2 doi: 10.1016/j.clinthera.2020.01.016. PMID: 32139174
Cohen LE
Curr Opin Endocrinol Diabetes Obes 2016 Aug;23(4):339-44. doi: 10.1097/MED.0000000000000264. PMID: 27258775

Diagnosis

Rand CM, Weese-Mayer DE
Clin Auton Res 2023 Jun;33(3):211-213. doi: 10.1007/s10286-023-00957-7. PMID: 37273037Free PMC Article
Khaytin I, Victor AK, Barclay SF, Benson LA, Slattery SM, Rand CM, Kurek KC, Weese-Mayer DE
Clin Auton Res 2023 Jun;33(3):251-268. Epub 2023 May 10 doi: 10.1007/s10286-023-00936-y. PMID: 37162653
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Huhmann K
Clin Ther 2020 Mar;42(3):401-407. Epub 2020 Mar 2 doi: 10.1016/j.clinthera.2020.01.016. PMID: 32139174
Angulo MA, Butler MG, Cataletto ME
J Endocrinol Invest 2015 Dec;38(12):1249-63. Epub 2015 Jun 11 doi: 10.1007/s40618-015-0312-9. PMID: 26062517Free PMC Article

Therapy

Itani R, Gillett ES, Perez IA
Curr Neurol Neurosci Rep 2023 Mar;23(3):25-32. Epub 2023 Feb 15 doi: 10.1007/s11910-023-01254-6. PMID: 36790642Free PMC Article
Mendes NF, Velloso LA
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Mol Metab 2019 Sep;27:1-10. Epub 2019 Jun 29 doi: 10.1016/j.molmet.2019.06.022. PMID: 31300352Free PMC Article
Williams LM
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Obermann M, Holle D
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Prognosis

van Santen HM, van Schaik J, van Roessel IMAA, Beckhaus J, Boekhoff S, Müller HL
Eur J Endocrinol 2023 Feb 14;188(2) doi: 10.1093/ejendo/lvad009. PMID: 36737045
Engel DF, Velloso LA
Neuropharmacology 2022 May 1;208:108983. Epub 2022 Feb 8 doi: 10.1016/j.neuropharm.2022.108983. PMID: 35143850
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Aihara Y, Chiba K, Eguchi S, Amano K, Kawamata T
Neurol Med Chir (Tokyo) 2018 Jan 15;58(1):1-9. Epub 2017 Nov 9 doi: 10.2176/nmc.ra.2017-0081. PMID: 29118304Free PMC Article
Garnett MR, Puget S, Grill J, Sainte-Rose C
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Clinical prediction guides

Xu Z, Wang Y, Duan L, Yao Y, Feng F, Wang L, Deng K, You H, Yang H, Lu L, Zhu H
Neuroendocrinology 2023;113(5):479-488. Epub 2023 Feb 6 doi: 10.1159/000529537. PMID: 36746124
Li Q, Bao L, Liu M, Zhang R, Shi H, Chen H
Muscle Nerve 2023 Mar;67(3):231-236. Epub 2023 Jan 9 doi: 10.1002/mus.27781. PMID: 36576109
Tauber M, Hoybye C
Lancet Diabetes Endocrinol 2021 Apr;9(4):235-246. Epub 2021 Feb 26 doi: 10.1016/S2213-8587(21)00002-4. PMID: 33647242
Carmo-Silva S, Cavadas C
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Schwabe AD, Lippe BM, Chang RJ, Pops MA, Yager J
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Recent systematic reviews

Van Roessel IMAA, Van Den Brink M, Dekker J, Ruitenburg-van Essen BG, Tissing WJE, van Santen HM
Clin Nutr 2024 Aug;43(8):1798-1811. Epub 2024 May 27 doi: 10.1016/j.clnu.2024.05.028. PMID: 38955055
Devi S, Gedda DUK, Chawla S, Doucette J, Yadav N, Mirshahi S, de Moura LP, Velloso LA, Mekary RA
Int J Neurosci 2024 Jun;134(1):75-87. Epub 2022 Jul 19 doi: 10.1080/00207454.2022.2086127. PMID: 35659180
Rizzi M, Nichelatti M, Ferri L, Consales A, De Benedictis A, Cossu M; Commission for Epilepsy Surgery of the Italian League Against Epilepsy (LICE)
Epilepsy Res 2023 Dec;198:107261. Epub 2023 Nov 20 doi: 10.1016/j.eplepsyres.2023.107261. PMID: 38006630
Xu Z, Wang Y, Duan L, Yao Y, Feng F, Wang L, Deng K, You H, Yang H, Lu L, Zhu H
Neuroendocrinology 2023;113(5):479-488. Epub 2023 Feb 6 doi: 10.1159/000529537. PMID: 36746124
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531

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