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Recurrent hypersomnia

MedGen UID:
155520
•Concept ID:
C0751226
•
Disease or Syndrome
Synonym: Episodic hypersomnia
SNOMED CT: Recurrent hypersomnia (426451004)
 
HPO: HP:0007200
Monarch Initiative: MONDO:0004617

Definition

Recurrent episodes of severe hypersomnia are accompanied by cognitive and behavioral disturbances, including confusion, derealization, apathy, compulsive eating, and hypersexuality. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent hypersomnia

Conditions with this feature

Kleine-Levin syndrome
MedGen UID:
61511
•Concept ID:
C0206085
•
Disease or Syndrome
The Kleine-Levin hibernation syndrome, a rare disorder that occurs predominantly in males, is characterized by episodic attacks of aberrant behavior, hypersomnia, and increased feeding (megaphagia) and sex drives (Kleine, 1925; Levin, 1929).
See: Condition Record
Kleine-Levin syndrome

Professional guidelines

PubMed

Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin.
Morgenthaler TI, Kapur VK, Brown T, Swick TJ, Alessi C, Aurora RN, Boehlecke B, Chesson AL Jr, Friedman L, Maganti R, Owens J, Pancer J, Zak R; Standards of Practice Committee of the American Academy of Sleep Medicine
Sleep 2007 Dec;30(12):1705-11. doi: 10.1093/sleep/30.12.1705. PMID: 18246980Free PMC Article
Differential diagnosis in hypersomnia.
Dauvilliers Y
Curr Neurol Neurosci Rep 2006 Mar;6(2):156-62. doi: 10.1007/s11910-996-0039-2. PMID: 16522270

Recent clinical studies

Etiology

Different circadian rest-active rhythms in Kleine-Levin syndrome: a prospective and case-control study.
Lin C, Chin WC, Huang YS, Chu KC, Paiva T, Chen CC, Guilleminault C
Sleep 2021 Sep 13;44(9) doi: 10.1093/sleep/zsab096. PMID: 33851710
Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention.
Smolensky MH, Hermida RC, Reinberg A, Sackett-Lundeen L, Portaluppi F
Chronobiol Int 2016;33(8):1101-19. Epub 2016 Jun 16 doi: 10.1080/07420528.2016.1184678. PMID: 27308960
Prevalence and Mimics of Kleine-Levin Syndrome: A Survey in French-Speaking Switzerland.
Habra O, Heinzer R, Haba-Rubio J, Rossetti AO
J Clin Sleep Med 2016 Aug 15;12(8):1083-7. doi: 10.5664/jcsm.6040. PMID: 27250808Free PMC Article
Recurrent hypersomnia following traumatic brain injury.
Billiard M, Podesta C
Sleep Med 2013 May;14(5):462-5. Epub 2013 Mar 13 doi: 10.1016/j.sleep.2013.01.009. PMID: 23499199
Differential diagnosis in hypersomnia.
Dauvilliers Y
Curr Neurol Neurosci Rep 2006 Mar;6(2):156-62. doi: 10.1007/s11910-996-0039-2. PMID: 16522270

Diagnosis

Kleine-Levin syndrome: clues to aetiology.
AlShareef SM, Smith RM, BaHammam AS
Sleep Breath 2018 Sep;22(3):613-623. Epub 2018 Mar 12 doi: 10.1007/s11325-017-1617-z. PMID: 29532411Free PMC Article
Kleine-Levin Syndrome.
Miglis MG, Guilleminault C
Curr Neurol Neurosci Rep 2016 Jun;16(6):60. doi: 10.1007/s11910-016-0653-6. PMID: 27137943
Kleine-Levin Syndrome.
Arnulf I
Sleep Med Clin 2015 Jun;10(2):151-61. doi: 10.1016/j.jsmc.2015.02.001. PMID: 26055863
Differential diagnosis in hypersomnia.
Dauvilliers Y
Curr Neurol Neurosci Rep 2006 Mar;6(2):156-62. doi: 10.1007/s11910-996-0039-2. PMID: 16522270
Hypersomnia.
Dauvilliers Y, Buguet A
Dialogues Clin Neurosci 2005;7(4):347-56. doi: 10.31887/DCNS.2005.7.4/ydauvilliers. PMID: 16416710Free PMC Article

Therapy

Menstruation-Related Hypersomnia Treated with Hormonal Contraception: Case Report and Review of Literature.
Suau GM, Cabrera V, Romaguera J
P R Health Sci J 2016 Mar;35(1):40-2. PMID: 26932284
Treatment of Kleine-Levin syndrome with acetazolamide.
Kapson B, Nayar S, Spiegel R
J Clin Sleep Med 2014 Oct 15;10(10):1153-4. doi: 10.5664/jcsm.4124. PMID: 25317098Free PMC Article
Kleine-Levin syndrome: a case report and review of literature.
Das S, Gupta R, Dhyani M, Raghuvanshi S
Pediatr Neurol 2014 Apr;50(4):411-6. Epub 2014 Jan 6 doi: 10.1016/j.pediatrneurol.2014.01.003. PMID: 24630285
Gabapentin for Kleine-Levin syndrome.
Itokawa K, Fukui M, Ninomiya M, Yamamoto T, Imabayashi E, Tamura N, Matsuda H, Araki N
Intern Med 2009;48(13):1183-5. Epub 2009 Jul 1 doi: 10.2169/internalmedicine.48.2204. PMID: 19571456
Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin.
Morgenthaler TI, Kapur VK, Brown T, Swick TJ, Alessi C, Aurora RN, Boehlecke B, Chesson AL Jr, Friedman L, Maganti R, Owens J, Pancer J, Zak R; Standards of Practice Committee of the American Academy of Sleep Medicine
Sleep 2007 Dec;30(12):1705-11. doi: 10.1093/sleep/30.12.1705. PMID: 18246980Free PMC Article

Prognosis

Different circadian rest-active rhythms in Kleine-Levin syndrome: a prospective and case-control study.
Lin C, Chin WC, Huang YS, Chu KC, Paiva T, Chen CC, Guilleminault C
Sleep 2021 Sep 13;44(9) doi: 10.1093/sleep/zsab096. PMID: 33851710
Kleine-Levin Syndrome.
Miglis MG, Guilleminault C
Curr Neurol Neurosci Rep 2016 Jun;16(6):60. doi: 10.1007/s11910-016-0653-6. PMID: 27137943
Polysomnography in Kleine-Levin syndrome.
Huang YS, Lin YH, Guilleminault C
Neurology 2008 Mar 4;70(10):795-801. doi: 10.1212/01.wnl.0000304133.00875.2b. PMID: 18316691

Clinical prediction guides

Different circadian rest-active rhythms in Kleine-Levin syndrome: a prospective and case-control study.
Lin C, Chin WC, Huang YS, Chu KC, Paiva T, Chen CC, Guilleminault C
Sleep 2021 Sep 13;44(9) doi: 10.1093/sleep/zsab096. PMID: 33851710
Kleine-Levin syndrome: a case report and review of literature.
Das S, Gupta R, Dhyani M, Raghuvanshi S
Pediatr Neurol 2014 Apr;50(4):411-6. Epub 2014 Jan 6 doi: 10.1016/j.pediatrneurol.2014.01.003. PMID: 24630285
Polysomnography in Kleine-Levin syndrome.
Huang YS, Lin YH, Guilleminault C
Neurology 2008 Mar 4;70(10):795-801. doi: 10.1212/01.wnl.0000304133.00875.2b. PMID: 18316691
Prolonged polysomnography in a case with recurrent hypersomnia.
Tanabe E, Yara K, Mastuura M, Takahashi S, Sakai T, Kojima T
Psychiatry Clin Neurosci 1998 Apr;52(2):204-5. doi: 10.1111/j.1440-1819.1998.tb01032.x. PMID: 9628153
Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report.
Yamada N
Psychiatry Clin Neurosci 1995 Dec;49(5-6):305-7. doi: 10.1111/j.1440-1819.1995.tb01907.x. PMID: 8726119

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