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Inappropriate ACTH Secretion Syndrome

MedGen UID:
155831
•Concept ID:
C0751220
•
Disease or Syndrome
Synonyms: Adrenocorticotropic Hormone, Inappropriate Secretion; Inappropriate Adrenocorticotropic Hormone Secretion

Professional guidelines

PubMed

Consensus on diagnosis and management of Cushing's disease: a guideline update.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK
Lancet Diabetes Endocrinol 2021 Dec;9(12):847-875. Epub 2021 Oct 20 doi: 10.1016/S2213-8587(21)00235-7. PMID: 34687601Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844

Recent clinical studies

Etiology

Consensus on diagnosis and management of Cushing's disease: a guideline update.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK
Lancet Diabetes Endocrinol 2021 Dec;9(12):847-875. Epub 2021 Oct 20 doi: 10.1016/S2213-8587(21)00235-7. PMID: 34687601Free PMC Article
Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
The Treatment of Cushing's Disease.
Pivonello R, De Leo M, Cozzolino A, Colao A
Endocr Rev 2015 Aug;36(4):385-486. Epub 2015 Jun 11 doi: 10.1210/er.2013-1048. PMID: 26067718Free PMC Article
Cushing's disease.
Castinetti F, Morange I, Conte-Devolx B, Brue T
Orphanet J Rare Dis 2012 Jun 18;7:41. doi: 10.1186/1750-1172-7-41. PMID: 22710101Free PMC Article
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950

Diagnosis

Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Consensus on diagnosis and management of Cushing's disease: a guideline update.
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK
Lancet Diabetes Endocrinol 2021 Dec;9(12):847-875. Epub 2021 Oct 20 doi: 10.1016/S2213-8587(21)00235-7. PMID: 34687601Free PMC Article
Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844

Therapy

Cushing's disease: adrenal steroidogenesis inhibitors.
Pivonello R, Simeoli C, Di Paola N, Colao A
Pituitary 2022 Oct;25(5):726-732. Epub 2022 Aug 29 doi: 10.1007/s11102-022-01262-8. PMID: 36036308Free PMC Article
Randomized Trial of Osilodrostat for the Treatment of Cushing Disease.
Gadelha M, Bex M, Feelders RA, Heaney AP, Auchus RJ, Gilis-Januszewska A, Witek P, Belaya Z, Yu Y, Liao Z, Ku CHC, Carvalho D, Roughton M, Wojna J, Pedroncelli AM, Snyder PJ
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2882-e2895. doi: 10.1210/clinem/dgac178. PMID: 35325149Free PMC Article
Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Perinatal Endocrine Challenges.
Muir AB, Rose SR
Clin Perinatol 2018 Mar;45(1):xvii-xviii. Epub 2017 Dec 1 doi: 10.1016/j.clp.2017.11.004. PMID: 29406016
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Prognosis

Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Epidemiology and mortality of Cushing's syndrome.
Hakami OA, Ahmed S, Karavitaki N
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101521. Epub 2021 Mar 15 doi: 10.1016/j.beem.2021.101521. PMID: 33766428
Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review.
Perlman JE, Johnston PC, Hui F, Mulligan G, Weil RJ, Recinos PF, Yogi-Morren D, Salvatori R, Mukherjee D, Gallia G, Kennedy L, Hamrahian AH
J Clin Endocrinol Metab 2021 Apr 23;106(5):e1953-e1967. doi: 10.1210/clinem/dgab012. PMID: 33421066Free PMC Article
Nelson's Syndrome: An Update.
Fountas A, Karavitaki N
Endocrinol Metab Clin North Am 2020 Sep;49(3):413-432. doi: 10.1016/j.ecl.2020.05.004. PMID: 32741480
Cushing's disease: pathobiology, diagnosis, and management.
Lonser RR, Nieman L, Oldfield EH
J Neurosurg 2017 Feb;126(2):404-417. Epub 2016 Apr 22 doi: 10.3171/2016.1.JNS152119. PMID: 27104844

Clinical prediction guides

Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review.
Perlman JE, Johnston PC, Hui F, Mulligan G, Weil RJ, Recinos PF, Yogi-Morren D, Salvatori R, Mukherjee D, Gallia G, Kennedy L, Hamrahian AH
J Clin Endocrinol Metab 2021 Apr 23;106(5):e1953-e1967. doi: 10.1210/clinem/dgab012. PMID: 33421066Free PMC Article
Editorial: Current Clinical and Pre-Clinical Progress in Cushing's Disease.
Stalla GK, Arzt E, Losa M, Renner U
Front Endocrinol (Lausanne) 2020;11:612321. Epub 2020 Nov 19 doi: 10.3389/fendo.2020.612321. PMID: 33329407Free PMC Article
Nelson's Syndrome: An Update.
Fountas A, Karavitaki N
Endocrinol Metab Clin North Am 2020 Sep;49(3):413-432. doi: 10.1016/j.ecl.2020.05.004. PMID: 32741480
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Diagnosis of Cushing's disease.
Daniel E, Newell-Price JD
Pituitary 2015 Apr;18(2):206-10. doi: 10.1007/s11102-015-0649-2. PMID: 25786387

Recent systematic reviews

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review.
Abufaraj M, Ramadan R, Alkhatib A
Curr Oncol 2024 Mar 21;31(3):1618-1632. doi: 10.3390/curroncol31030123. PMID: 38534956Free PMC Article
Crooke Cell Adenoma Confers Poorer Endocrinological Outcomes Compared with Corticotroph Adenoma: Results of a Multicenter, International Analysis.
Findlay MC, Drexler R, Azab M, Karbe A, Rotermund R, Ricklefs FL, Flitsch J, Smith TR, Kilgallon JL, Honegger J, Nasi-Kordhishti I, Gardner PA, Gersey ZC, Abdallah HM, Jane JA Jr, Marino AC, Knappe UJ, Uksul N, Rzaev JA, Bervitskiy AV, Schroeder HWS, Eördögh M, Losa M, Mortini P, Gerlach R, Antunes ACM, Couldwell WT, Budohoski KP, Rennert RC, Karsy M
World Neurosurg 2023 Dec;180:e376-e391. Epub 2023 Sep 25 doi: 10.1016/j.wneu.2023.09.076. PMID: 37757948
Thrombosis in Cushing's disease; raising the flag of concern.
Rabiei H, Shahbandi A, Sabahi M, Mandel M, Adada B, Borghei-Razavi H
Neurosurg Rev 2023 Jan 6;46(1):32. doi: 10.1007/s10143-022-01941-x. PMID: 36604392
Dynamic Testing for Differential Diagnosis of ACTH-Dependent Cushing Syndrome: A Systematic Review and Meta-analysis.
Ceccato F, Barbot M, Mondin A, Boscaro M, Fleseriu M, Scaroni C
J Clin Endocrinol Metab 2023 Apr 13;108(5):e178-e188. doi: 10.1210/clinem/dgac686. PMID: 36453141
MRI-Negative Cushing's Disease: A Review on Therapeutic Management.
Sabahi M, Shahbazi T, Maroufi SF, Vidal K, Recinos PF, Kshettry VR, Roser F, Adada B, Borghei-Razavi H
World Neurosurg 2022 Jun;162:126-137.e1. Epub 2022 Mar 22 doi: 10.1016/j.wneu.2022.03.076. PMID: 35338018

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