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Tactile Allodynia

MedGen UID:
148259
•Concept ID:
C0751213
•
Sign or Symptom
Synonyms: Allodynia, Tactile; Hyperalgesia, Tactile

Professional guidelines

PubMed

Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article
Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain.
Xu JJ, Diaz P, Astruc-Diaz F, Craig S, Munoz E, Naguib M
Anesth Analg 2010 Jul;111(1):99-109. Epub 2010 Jun 3 doi: 10.1213/ANE.0b013e3181e0cdaf. PMID: 20522703Free PMC Article
Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia.
Davies PS, Galer BS
Drugs 2004;64(9):937-47. doi: 10.2165/00003495-200464090-00002. PMID: 15101784

Recent clinical studies

Etiology

A Direct Comparison of Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interfaces to Prevent Neuroma Pain.
Senger JB, Hardy P, Thorkelsson A, Duia S, Hsiao R, Kemp SWP, Tenorio G, Rajshekar M, Kerr BJ, Chan KM, Rabey KN, Webber CA
Neurosurgery 2023 Nov 1;93(5):1180-1191. Epub 2023 Jun 2 doi: 10.1227/neu.0000000000002541. PMID: 37265342
Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS).
Murphy SF, Anker JF, Mazur DJ, Hall C, Schaeffer AJ, Thumbikat P
Prostate 2019 Feb;79(2):160-167. Epub 2018 Sep 21 doi: 10.1002/pros.23721. PMID: 30242864Free PMC Article
Tactile allodynia in patients with lumbar radicular pain (sciatica).
Defrin R, Devor M, Brill S
Pain 2014 Dec;155(12):2551-2559. Epub 2014 Sep 19 doi: 10.1016/j.pain.2014.09.015. PMID: 25242568
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article
Review of lidocaine patch 5% studies in the treatment of postherpetic neuralgia.
Davies PS, Galer BS
Drugs 2004;64(9):937-47. doi: 10.2165/00003495-200464090-00002. PMID: 15101784

Diagnosis

Molecular Mechanisms of the Sense of Touch: An Overview of Mechanical Transduction and Transmission in Merkel Discs of Whisker Hair Follicles and Some Clinical Perspectives.
Gu JG
Adv Exp Med Biol 2018;1099:1-12. doi: 10.1007/978-981-13-1756-9_1. PMID: 30306510
Tactile allodynia in patients with lumbar radicular pain (sciatica).
Defrin R, Devor M, Brill S
Pain 2014 Dec;155(12):2551-2559. Epub 2014 Sep 19 doi: 10.1016/j.pain.2014.09.015. PMID: 25242568
Central sensitization: implications for the diagnosis and treatment of pain.
Woolf CJ
Pain 2011 Mar;152(3 Suppl):S2-S15. Epub 2010 Oct 18 doi: 10.1016/j.pain.2010.09.030. PMID: 20961685Free PMC Article
Painful purinergic receptors.
Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF
J Pharmacol Exp Ther 2008 Feb;324(2):409-15. Epub 2007 Nov 27 doi: 10.1124/jpet.106.105890. PMID: 18042830
Spinal and supraspinal mechanisms of neuropathic pain.
Ossipov MH, Lai J, Malan TP Jr, Porreca F
Ann N Y Acad Sci 2000;909:12-24. doi: 10.1111/j.1749-6632.2000.tb06673.x. PMID: 10911921

Therapy

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.
Casselini CM, Parson HK, Frizzi KE, Marquez A, Smith DR, Guernsey L, Nemmani R, Tayarani A, Jolivalt CG, Weaver J, Fernyhough P, Vinik AI, Calcutt NA
Acta Neuropathol 2024 Mar 25;147(1):60. doi: 10.1007/s00401-024-02710-4. PMID: 38526612
Exploring the molecular pathways and therapeutic implications of angiogenesis in neuropathic pain.
Sharma A, Behl T, Sharma L, Shah OP, Yadav S, Sachdeva M, Rashid S, Bungau SG, Bustea C
Biomed Pharmacother 2023 Jun;162:114693. Epub 2023 Apr 14 doi: 10.1016/j.biopha.2023.114693. PMID: 37062217
PIEZO2 mediates injury-induced tactile pain in mice and humans.
Szczot M, Liljencrantz J, Ghitani N, Barik A, Lam R, Thompson JH, Bharucha-Goebel D, Saade D, Necaise A, Donkervoort S, Foley AR, Gordon T, Case L, Bushnell MC, Bönnemann CG, Chesler AT
Sci Transl Med 2018 Oct 10;10(462) doi: 10.1126/scitranslmed.aat9892. PMID: 30305456Free PMC Article
Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).
Luongo L, Starowicz K, Maione S, Di Marzo V
Pharmacol Res 2017 May;119:272-277. Epub 2017 Feb 22 doi: 10.1016/j.phrs.2017.02.019. PMID: 28237514
New therapy for neuropathic pain.
Mizoguchi H, Watanabe C, Yonezawa A, Sakurada S
Int Rev Neurobiol 2009;85:249-60. doi: 10.1016/S0074-7742(09)85019-8. PMID: 19607975

Prognosis

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies.
Furgała-Wojas A, Kowalska M, Nowaczyk A, Fijałkowski Ł, Sałat K
Curr Drug Metab 2020;21(7):548-561. doi: 10.2174/1389200221666200711155632. PMID: 32651960
Tactile allodynia in patients with lumbar radicular pain (sciatica).
Defrin R, Devor M, Brill S
Pain 2014 Dec;155(12):2551-2559. Epub 2014 Sep 19 doi: 10.1016/j.pain.2014.09.015. PMID: 25242568
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.
Liu H, Shiryaev SA, Chernov AV, Kim Y, Shubayev I, Remacle AG, Baranovskaya S, Golubkov VS, Strongin AY, Shubayev VI
J Neuroinflammation 2012 Jun 7;9:119. doi: 10.1186/1742-2094-9-119. PMID: 22676642Free PMC Article
New therapy for neuropathic pain.
Mizoguchi H, Watanabe C, Yonezawa A, Sakurada S
Int Rev Neurobiol 2009;85:249-60. doi: 10.1016/S0074-7742(09)85019-8. PMID: 19607975
Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans.
Dyck PJ, Peroutka S, Rask C, Burton E, Baker MK, Lehman KA, Gillen DA, Hokanson JL, O'Brien PC
Neurology 1997 Feb;48(2):501-5. doi: 10.1212/wnl.48.2.501. PMID: 9040746

Clinical prediction guides

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.
Casselini CM, Parson HK, Frizzi KE, Marquez A, Smith DR, Guernsey L, Nemmani R, Tayarani A, Jolivalt CG, Weaver J, Fernyhough P, Vinik AI, Calcutt NA
Acta Neuropathol 2024 Mar 25;147(1):60. doi: 10.1007/s00401-024-02710-4. PMID: 38526612
A Direct Comparison of Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interfaces to Prevent Neuroma Pain.
Senger JB, Hardy P, Thorkelsson A, Duia S, Hsiao R, Kemp SWP, Tenorio G, Rajshekar M, Kerr BJ, Chan KM, Rabey KN, Webber CA
Neurosurgery 2023 Nov 1;93(5):1180-1191. Epub 2023 Jun 2 doi: 10.1227/neu.0000000000002541. PMID: 37265342
Antineuropathic effect of 7-hydroxy-3,4-dihydrocadalin in streptozotocin-induced diabetic rodents.
Rocha-González HI, Ramírez-Aguilar M, Granados-Soto V, Reyes-García JG, Torres-López JE, Huerta-Cruz JC, Navarrete A
BMC Complement Altern Med 2014 Apr 7;14:129. doi: 10.1186/1472-6882-14-129. PMID: 24708659Free PMC Article
New therapy for neuropathic pain.
Mizoguchi H, Watanabe C, Yonezawa A, Sakurada S
Int Rev Neurobiol 2009;85:249-60. doi: 10.1016/S0074-7742(09)85019-8. PMID: 19607975
Spinal and supraspinal mechanisms of neuropathic pain.
Ossipov MH, Lai J, Malan TP Jr, Porreca F
Ann N Y Acad Sci 2000;909:12-24. doi: 10.1111/j.1749-6632.2000.tb06673.x. PMID: 10911921

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