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Fasciculation, Benign

MedGen UID:
155511
•Concept ID:
C0751144
•
Sign or Symptom
Synonyms: Benign Fasciculation; Benign Fasciculations; Fasciculations, Benign

Professional guidelines

PubMed

Treatment of various movement disorders with botulinum A toxin injection: an experience of 900 patients.
Poungvarin N, Devahastin V, Viriyavejakul A
J Med Assoc Thai 1995 Jun;78(6):281-8. PMID: 7561552

Recent clinical studies

Etiology

Autoimmune neuromyotonia.
Comperat L, Pegat A, Honnorat J, Joubert B
Curr Opin Neurol 2022 Oct 1;35(5):597-603. Epub 2022 Aug 19 doi: 10.1097/WCO.0000000000001104. PMID: 35989569
Fasciculations in Children.
Choi HW
Pediatr Neurol 2021 Dec;125:40-47. Epub 2021 Sep 6 doi: 10.1016/j.pediatrneurol.2021.08.008. PMID: 34628142
Transplacental lidocaine intoxication.
Demeulemeester V, Van Hautem H, Cools F, Lefevere J
J Neonatal Perinatal Med 2018;11(4):439-441. doi: 10.3233/NPM-1791. PMID: 30149475
A prospective study of benign fasciculation syndrome and anxiety.
Filippakis A, Jara J, Ventura N, Scala S, Scopa C, Ruthazer R, Karakis I, Srinivasan J, Russell JA, Ho DT
Muscle Nerve 2018 Dec;58(6):852-854. Epub 2018 Sep 11 doi: 10.1002/mus.26193. PMID: 30028521
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V
Lancet 1996 May 25;347(9013):1425-31. doi: 10.1016/s0140-6736(96)91680-3. PMID: 8676624

Diagnosis

Autoimmune neuromyotonia.
Comperat L, Pegat A, Honnorat J, Joubert B
Curr Opin Neurol 2022 Oct 1;35(5):597-603. Epub 2022 Aug 19 doi: 10.1097/WCO.0000000000001104. PMID: 35989569
Neuromuscular hyperexcitability syndromes.
De Wel B, Claeys KG
Curr Opin Neurol 2021 Oct 1;34(5):714-720. doi: 10.1097/WCO.0000000000000963. PMID: 34914668
A prospective study of benign fasciculation syndrome and anxiety.
Filippakis A, Jara J, Ventura N, Scala S, Scopa C, Ruthazer R, Karakis I, Srinivasan J, Russell JA, Ho DT
Muscle Nerve 2018 Dec;58(6):852-854. Epub 2018 Sep 11 doi: 10.1002/mus.26193. PMID: 30028521
Peripheral Nerve Hyperexcitability Syndromes.
Sawlani K, Katirji B
Continuum (Minneap Minn) 2017 Oct;23(5, Peripheral Nerve and Motor Neuron Disorders):1437-1450. doi: 10.1212/CON.0000000000000520. PMID: 28968370
Isaacs syndrome: A review.
Ahmed A, Simmons Z
Muscle Nerve 2015 Jul;52(1):5-12. Epub 2015 Mar 31 doi: 10.1002/mus.24632. PMID: 25736532

Therapy

Fasciculating toxicity.
Ranjan A, Jamshed N, Aggarwal P, Upadhyay V
Am J Emerg Med 2019 Apr;37(4):798.e1-798.e2. Epub 2019 Jan 21 doi: 10.1016/j.ajem.2019.01.033. PMID: 30686539
Transplacental lidocaine intoxication.
Demeulemeester V, Van Hautem H, Cools F, Lefevere J
J Neonatal Perinatal Med 2018;11(4):439-441. doi: 10.3233/NPM-1791. PMID: 30149475
Neuromyotonia.
Newsom-Davis J
Rev Neurol (Paris) 2004 May;160(5 Pt 2):S85-9. doi: 10.1016/s0035-3787(04)71010-3. PMID: 15269665
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V
Lancet 1996 May 25;347(9013):1425-31. doi: 10.1016/s0140-6736(96)91680-3. PMID: 8676624
Suxamethonium.
Durant NN, Katz RL
Br J Anaesth 1982 Feb;54(2):195-208. doi: 10.1093/bja/54.2.195. PMID: 7037028

Prognosis

Normal and abnormal spontaneous activity.
Rubin DI
Handb Clin Neurol 2019;160:257-279. doi: 10.1016/B978-0-444-64032-1.00017-5. PMID: 31277853
A prospective study of benign fasciculation syndrome and anxiety.
Filippakis A, Jara J, Ventura N, Scala S, Scopa C, Ruthazer R, Karakis I, Srinivasan J, Russell JA, Ho DT
Muscle Nerve 2018 Dec;58(6):852-854. Epub 2018 Sep 11 doi: 10.1002/mus.26193. PMID: 30028521
Disorders of motor neurons manifested by hyperactivity.
Grapperon AM, Attarian S
Rev Neurol (Paris) 2017 May;173(5):345-351. Epub 2017 Apr 28 doi: 10.1016/j.neurol.2017.04.002. PMID: 28457490
Skeletal muscle ultrasound.
Pillen S, van Alfen N
Neurol Res 2011 Dec;33(10):1016-24. doi: 10.1179/1743132811Y.0000000010. PMID: 22196753
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V
Lancet 1996 May 25;347(9013):1425-31. doi: 10.1016/s0140-6736(96)91680-3. PMID: 8676624

Clinical prediction guides

Fasciculations in Children.
Choi HW
Pediatr Neurol 2021 Dec;125:40-47. Epub 2021 Sep 6 doi: 10.1016/j.pediatrneurol.2021.08.008. PMID: 34628142
Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development.
Chen X, Ku L, Mei R, Liu G, Xu C, Wen Z, Zhao X, Wang F, Xiao L, Feng Y
Transl Psychiatry 2017 Dec 18;7(12):1293. doi: 10.1038/s41398-017-0028-z. PMID: 29249816Free PMC Article
Lower motor neuron dysfunction in ALS.
de Carvalho M, Swash M
Clin Neurophysiol 2016 Jul;127(7):2670-81. Epub 2016 Apr 6 doi: 10.1016/j.clinph.2016.03.024. PMID: 27117334
Skeletal muscle ultrasound.
Pillen S, van Alfen N
Neurol Res 2011 Dec;33(10):1016-24. doi: 10.1179/1743132811Y.0000000010. PMID: 22196753
Aldicarb poisoning.
Ragoucy-Sengler C, Tracqui A, Chavonnet A, Daijardin JB, Simonetti M, Kintz P, Pileire B
Hum Exp Toxicol 2000 Dec;19(12):657-62. doi: 10.1191/096032700672133218. PMID: 11291736

Recent systematic reviews

Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials.
Vélez PA, Lara-Erazo V, Caballero-Lozada AF, Botero A, Lozada G, Velásquez AF, Villegas LM, Zorrilla-Vaca A
Rev Esp Anestesiol Reanim (Engl Ed) 2024 Apr;71(4):324-331. Epub 2023 Sep 4 doi: 10.1016/j.redare.2022.12.002. PMID: 37673208
The Association Between Benign Fasciculations and Health Anxiety: A Report of Two Cases and a Systematic Review of the Literature.
Blackman G, Cherfi Y, Morrin H, Ellis CM, Bashford J, Ruths F, David AS
Psychosomatics 2019 Sep-Oct;60(5):499-507. Epub 2019 Apr 10 doi: 10.1016/j.psym.2019.04.001. PMID: 31174866

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