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Subclinical Seizure

MedGen UID:
148240
•Concept ID:
C0751112
•
Disease or Syndrome
Synonyms: Seizure, Subclinical; Seizures, Subclinical; Subclinical Seizures

Definition

A seizure with no apparent symptoms. [from NCI]

Professional guidelines

PubMed

Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations.
Schmitz B, Lattanzi S, Vonck K, Kälviäinen R, Nashef L, Ben-Menachem E
Epilepsia Open 2023 Dec;8(4):1241-1255. Epub 2023 Oct 3 doi: 10.1002/epi4.12830. PMID: 37743544Free PMC Article
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options.
Löscher W, Potschka H, Sisodiya SM, Vezzani A
Pharmacol Rev 2020 Jul;72(3):606-638. doi: 10.1124/pr.120.019539. PMID: 32540959Free PMC Article
Seizure classification, etiology, and management.
Shellhaas RA
Handb Clin Neurol 2019;162:347-361. doi: 10.1016/B978-0-444-64029-1.00017-5. PMID: 31324320

Recent clinical studies

Etiology

Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study.
Mehta N, Shellhaas RA, McCulloch CE, Chang T, Wusthoff CJ, Abend NS, Lemmon ME, Chu CJ, Massey SL, Franck LS, Thomas C, Soul JS, Rogers E, Numis A, Glass HC
Pediatr Neurol 2022 Dec;137:54-61. Epub 2022 Sep 19 doi: 10.1016/j.pediatrneurol.2022.09.001. PMID: 36270133
Subclinical seizures on stereotactic EEG: characteristics and prognostic value.
Cox BC, Khattak JF, Starnes K, Brinkmann BH, Tatum WO, Noe KH, Van Gompel JJ, Miller KJ, Marsh WR, Grewal SS, Zimmerman RS, So EL, Wong-Kisiel LC, Burkholder DB
Seizure 2022 Oct;101:96-102. Epub 2022 Jul 29 doi: 10.1016/j.seizure.2022.07.015. PMID: 35939857
Non-neurophysiologist Physicians and Nurses Can Detect Subclinical Seizures in Children Using a Panel of Quantitative EEG Trends and a Seizure Detection Algorithm.
Swarnalingam ES, RamachandranNair R, Choong KLM, Jones KC
J Clin Neurophysiol 2022 Sep 1;39(6):453-458. Epub 2020 Dec 29 doi: 10.1097/WNP.0000000000000812. PMID: 33417383
Detecting silent seizures by their sound.
Parvizi J, Gururangan K, Razavi B, Chafe C
Epilepsia 2018 Apr;59(4):877-884. Epub 2018 Mar 20 doi: 10.1111/epi.14043. PMID: 29558565
Prevalence and predictors of subclinical seizures during scalp video-EEG monitoring in patients with epilepsy.
Jin B, Wang S, Yang L, Shen C, Ding Y, Guo Y, Wang Z, Zhu J, Wang S, Ding M
Int J Neurosci 2017 Aug;127(8):651-658. Epub 2016 Aug 28 doi: 10.1080/00207454.2016.1220946. PMID: 27569054

Diagnosis

Subclinical seizures on stereotactic EEG: characteristics and prognostic value.
Cox BC, Khattak JF, Starnes K, Brinkmann BH, Tatum WO, Noe KH, Van Gompel JJ, Miller KJ, Marsh WR, Grewal SS, Zimmerman RS, So EL, Wong-Kisiel LC, Burkholder DB
Seizure 2022 Oct;101:96-102. Epub 2022 Jul 29 doi: 10.1016/j.seizure.2022.07.015. PMID: 35939857
Response characteristics of objective perimetry in persons living with epilepsy.
Ali EN, Lueck CJ, Carle CF, Martin KL, Borbelj A, Maddess T
J Neurol Sci 2022 May 15;436:120237. Epub 2022 Mar 25 doi: 10.1016/j.jns.2022.120237. PMID: 35358854
Non-neurophysiologist Physicians and Nurses Can Detect Subclinical Seizures in Children Using a Panel of Quantitative EEG Trends and a Seizure Detection Algorithm.
Swarnalingam ES, RamachandranNair R, Choong KLM, Jones KC
J Clin Neurophysiol 2022 Sep 1;39(6):453-458. Epub 2020 Dec 29 doi: 10.1097/WNP.0000000000000812. PMID: 33417383
Detecting silent seizures by their sound.
Parvizi J, Gururangan K, Razavi B, Chafe C
Epilepsia 2018 Apr;59(4):877-884. Epub 2018 Mar 20 doi: 10.1111/epi.14043. PMID: 29558565
Does the kindling model of epilepsy contribute to our understanding of multiple chemical sensitivity?
Gilbert ME
Ann N Y Acad Sci 2001 Mar;933:68-91. doi: 10.1111/j.1749-6632.2001.tb05815.x. PMID: 12000037

Therapy

Breach Rhythm May Be Suppressed as a Form of Todd's Paralysis.
Lyudmilov C, Petersone D, Schmidt C, Bösel J, Rösche J
J Clin Neurophysiol 2020 May;37(3):271-273. doi: 10.1097/WNP.0000000000000683. PMID: 31977570
Continuous electroencephalography in pediatric traumatic brain injury: Seizure characteristics and outcomes.
Vaewpanich J, Reuter-Rice K
Epilepsy Behav 2016 Sep;62:225-30. Epub 2016 Aug 5 doi: 10.1016/j.yebeh.2016.07.012. PMID: 27500827Free PMC Article
Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial.
van Rooij LG, Toet MC, van Huffelen AC, Groenendaal F, Laan W, Zecic A, de Haan TR, van Straaten IL, Vrancken S, van Wezel G, van der Sluijs J, Ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS
Pediatrics 2010 Feb;125(2):e358-66. Epub 2010 Jan 25 doi: 10.1542/peds.2009-0136. PMID: 20100767
Keeping cool in acute liver failure: rationale for the use of mild hypothermia.
Vaquero J, Rose C, Butterworth RF
J Hepatol 2005 Dec;43(6):1067-77. Epub 2005 Oct 10 doi: 10.1016/j.jhep.2005.05.039. PMID: 16246452
Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: a controlled clinical trial.
Ellis AJ, Wendon JA, Williams R
Hepatology 2000 Sep;32(3):536-41. doi: 10.1053/jhep.2000.9775. PMID: 10960446

Prognosis

Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study.
Mehta N, Shellhaas RA, McCulloch CE, Chang T, Wusthoff CJ, Abend NS, Lemmon ME, Chu CJ, Massey SL, Franck LS, Thomas C, Soul JS, Rogers E, Numis A, Glass HC
Pediatr Neurol 2022 Dec;137:54-61. Epub 2022 Sep 19 doi: 10.1016/j.pediatrneurol.2022.09.001. PMID: 36270133
Subclinical seizures on stereotactic EEG: characteristics and prognostic value.
Cox BC, Khattak JF, Starnes K, Brinkmann BH, Tatum WO, Noe KH, Van Gompel JJ, Miller KJ, Marsh WR, Grewal SS, Zimmerman RS, So EL, Wong-Kisiel LC, Burkholder DB
Seizure 2022 Oct;101:96-102. Epub 2022 Jul 29 doi: 10.1016/j.seizure.2022.07.015. PMID: 35939857
Prevalence and predictors of subclinical seizures during scalp video-EEG monitoring in patients with epilepsy.
Jin B, Wang S, Yang L, Shen C, Ding Y, Guo Y, Wang Z, Zhu J, Wang S, Ding M
Int J Neurosci 2017 Aug;127(8):651-658. Epub 2016 Aug 28 doi: 10.1080/00207454.2016.1220946. PMID: 27569054
Continuous electroencephalography in pediatric traumatic brain injury: Seizure characteristics and outcomes.
Vaewpanich J, Reuter-Rice K
Epilepsy Behav 2016 Sep;62:225-30. Epub 2016 Aug 5 doi: 10.1016/j.yebeh.2016.07.012. PMID: 27500827Free PMC Article
Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure: a controlled clinical trial.
Ellis AJ, Wendon JA, Williams R
Hepatology 2000 Sep;32(3):536-41. doi: 10.1053/jhep.2000.9775. PMID: 10960446

Clinical prediction guides

Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study.
Mehta N, Shellhaas RA, McCulloch CE, Chang T, Wusthoff CJ, Abend NS, Lemmon ME, Chu CJ, Massey SL, Franck LS, Thomas C, Soul JS, Rogers E, Numis A, Glass HC
Pediatr Neurol 2022 Dec;137:54-61. Epub 2022 Sep 19 doi: 10.1016/j.pediatrneurol.2022.09.001. PMID: 36270133
Subclinical seizures on stereotactic EEG: characteristics and prognostic value.
Cox BC, Khattak JF, Starnes K, Brinkmann BH, Tatum WO, Noe KH, Van Gompel JJ, Miller KJ, Marsh WR, Grewal SS, Zimmerman RS, So EL, Wong-Kisiel LC, Burkholder DB
Seizure 2022 Oct;101:96-102. Epub 2022 Jul 29 doi: 10.1016/j.seizure.2022.07.015. PMID: 35939857
Response characteristics of objective perimetry in persons living with epilepsy.
Ali EN, Lueck CJ, Carle CF, Martin KL, Borbelj A, Maddess T
J Neurol Sci 2022 May 15;436:120237. Epub 2022 Mar 25 doi: 10.1016/j.jns.2022.120237. PMID: 35358854
Clinical value and predictors of subclinical seizures in patients with temporal lobe epilepsy undergoing scalp video-EEG monitoring.
Wang S, Jin B, Yang L, Chen C, Ding Y, Guo Y, Wang Z, Ming W, Tang Y, Wang S, Ding M
J Clin Neurosci 2017 Oct;44:214-217. Epub 2017 Jul 12 doi: 10.1016/j.jocn.2017.06.071. PMID: 28711291
Prevalence and predictors of subclinical seizures during scalp video-EEG monitoring in patients with epilepsy.
Jin B, Wang S, Yang L, Shen C, Ding Y, Guo Y, Wang Z, Zhu J, Wang S, Ding M
Int J Neurosci 2017 Aug;127(8):651-658. Epub 2016 Aug 28 doi: 10.1080/00207454.2016.1220946. PMID: 27569054

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