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Progressive spastic paraparesis

MedGen UID:
488935
•Concept ID:
C0747251
•
Sign or Symptom
HPO: HP:0007199

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Progressive spastic paraparesis

Professional guidelines

PubMed

Management of spinal dural arterio-venous fistulas. Report of 12 cases and review of literature.
Rashad S, Abdel-Bary M, Aziz W, Hassan T
Clin Neurol Neurosurg 2014 Oct;125:81-6. Epub 2014 Jul 27 doi: 10.1016/j.clineuro.2014.07.028. PMID: 25108697
Progressive spastic paraparesis: hereditary spastic paraplegia and its relation to primary and amyotrophic lateral sclerosis.
Fink JK
Semin Neurol 2001 Jun;21(2):199-207. doi: 10.1055/s-2001-15265. PMID: 11442328
Differential diagnosis of progressive spastic paraparesis.
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480

Recent clinical studies

Therapy

Adolescent/Adult-Onset Leukodystrophy with MTHFR Deficiency - A Treatable Cause.
Kumar NH, Mounika KJ, Sundarachary NV
Neurol India 2023 Mar-Apr;71(2):326-328. doi: 10.4103/0028-3886.375409. PMID: 37148062
Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Nozuma S, Kubota R, Jacobson S
J Neurovirol 2020 Oct;26(5):652-663. Epub 2020 Jul 23 doi: 10.1007/s13365-020-00881-w. PMID: 32705480Free PMC Article
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Treatment of myelopathy in Sjögren syndrome with a combination of prednisone and cyclophosphamide.
Williams CS, Butler E, Román GC
Arch Neurol 2001 May;58(5):815-9. doi: 10.1001/archneur.58.5.815. PMID: 11346378

Prognosis

Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Autosomal-dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function.
Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, de Noordhout AM, Maré R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH, Crow YJ, Van Maldergem L
Hum Mutat 2018 Aug;39(8):1076-1080. Epub 2018 Jun 4 doi: 10.1002/humu.23554. PMID: 29782060Free PMC Article
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
The neurologic manifestations of primary HIV infection.
Haist SA
J Ky Med Assoc 1989 Feb;87(2):75-7. PMID: 2656895

Clinical prediction guides

White matter abnormalities in 15 subjects with SPG76.
Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Clinical characteristics of Taiwanese patients with Hereditary spastic paraplegia type 5.
Chou CT, Soong BW, Lin KP, Tsai YS, Jih KY, Liao YC, Lee YC
Ann Clin Transl Neurol 2020 Apr;7(4):486-496. Epub 2020 Mar 22 doi: 10.1002/acn3.51019. PMID: 32202070Free PMC Article
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I).
Gessain A, Gout O
Ann Intern Med 1992 Dec 1;117(11):933-46. doi: 10.7326/0003-4819-117-11-933. PMID: 1443956

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