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Chronic post-traumatic stress disorder

MedGen UID:
149098
•Concept ID:
C0730525
•
Mental or Behavioral Dysfunction
Synonyms: Chronic Post Traumatic Stress Disorder; Chronic Post-Traumatic Stress Disorder
SNOMED CT: Chronic post-traumatic stress disorder (313182004)

Professional guidelines

PubMed

Unilateral amygdala ablation: a potential treatment option for severe chronic post-traumatic stress disorder (PTSD)?
Teye-Botchway L, Willie JT, van Rooij SJH
Expert Rev Neurother 2023 Jun;23(6):483-486. Epub 2023 May 29 doi: 10.1080/14737175.2023.2218034. PMID: 37226517Free PMC Article
Symptom profiles and treatment status of older adults with chronic post-traumatic stress disorder.
Rutherford BR, Zilcha-Mano S, Chrisanthopolous M, Salzman C, Zhu C, Cimino N, Yehuda R, Neria Y, Roose SP
Int J Geriatr Psychiatry 2021 Aug;36(8):1216-1222. Epub 2021 Feb 26 doi: 10.1002/gps.5514. PMID: 33577126
TENTS guidelines: development of post-disaster psychosocial care guidelines through a Delphi process.
Bisson JI, Tavakoly B, Witteveen AB, Ajdukovic D, Jehel L, Johansen VJ, Nordanger D, Orengo Garcia F, Punamaki RL, Schnyder U, Sezgin AU, Wittmann L, Olff M
Br J Psychiatry 2010 Jan;196(1):69-74. doi: 10.1192/bjp.bp.109.066266. PMID: 20044665

Recent clinical studies

Etiology

Abnormal rapid eye movement sleep atonia control in chronic post-traumatic stress disorder.
Feemster JC, Steele TA, Palermo KP, Ralston CL, Tao Y, Bauer DA, Edgar L, Rivera S, Walters-Smith M, Gossard TR, Teigen LN, Timm PC, Richardson JW, Auger RR, Kolla B, McCarter SJ, Boeve BF, Silber MH, St Louis EK
Sleep 2022 Mar 14;45(3) doi: 10.1093/sleep/zsab259. PMID: 34958372Free PMC Article
Symptom profiles and treatment status of older adults with chronic post-traumatic stress disorder.
Rutherford BR, Zilcha-Mano S, Chrisanthopolous M, Salzman C, Zhu C, Cimino N, Yehuda R, Neria Y, Roose SP
Int J Geriatr Psychiatry 2021 Aug;36(8):1216-1222. Epub 2021 Feb 26 doi: 10.1002/gps.5514. PMID: 33577126
Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults.
Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C
Cochrane Database Syst Rev 2013 Dec 13;2013(12):CD003388. doi: 10.1002/14651858.CD003388.pub4. PMID: 24338345Free PMC Article
A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U
J Psychopharmacol 2013 Jan;27(1):40-52. Epub 2012 Oct 31 doi: 10.1177/0269881112464827. PMID: 23118021
Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis.
Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S
Br J Psychiatry 2007 Feb;190:97-104. doi: 10.1192/bjp.bp.106.021402. PMID: 17267924

Diagnosis

Predictors of Chronic Combat-Related Post-Traumatic Stress Disorder Group Psychotherapy Favorable Outcomes; A Prospective Cohort Study in Croatia.
Cvitanušić S, Britvić D, Filipčić I, Frančišković T
Psychiatr Danub 2022 Fall;34(3):455-463. doi: 10.24869/psyd.2022.455. PMID: 36256983
Symptom profiles and treatment status of older adults with chronic post-traumatic stress disorder.
Rutherford BR, Zilcha-Mano S, Chrisanthopolous M, Salzman C, Zhu C, Cimino N, Yehuda R, Neria Y, Roose SP
Int J Geriatr Psychiatry 2021 Aug;36(8):1216-1222. Epub 2021 Feb 26 doi: 10.1002/gps.5514. PMID: 33577126
Differentiation chronic post traumatic stress disorder patients from healthy subjects using objective and subjective sleep-related parameters.
Tahmasian M, Jamalabadi H, Abedini M, Ghadami MR, Sepehry AA, Knight DC, Khazaie H
Neurosci Lett 2017 May 22;650:174-179. Epub 2017 Apr 24 doi: 10.1016/j.neulet.2017.04.042. PMID: 28450190
A longitudinal fMRI investigation in acute post-traumatic stress disorder (PTSD).
Ke J, Zhang L, Qi R, Li W, Hou C, Zhong Y, He Z, Li L, Lu G
Acta Radiol 2016 Nov;57(11):1387-1395. Epub 2016 Jul 20 doi: 10.1177/0284185115585848. PMID: 25995310
A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U
J Psychopharmacol 2013 Jan;27(1):40-52. Epub 2012 Oct 31 doi: 10.1177/0269881112464827. PMID: 23118021

Therapy

Theranostic pharmacology in PTSD: Neurobiology and timing.
Koek RJ, Luong TN
Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 2;90:245-263. Epub 2018 Dec 6 doi: 10.1016/j.pnpbp.2018.12.001. PMID: 30529001
Nonconventional interventions for chronic post-traumatic stress disorder: Ketamine, repetitive trans-cranial magnetic stimulation (rTMS), and alternative approaches.
Pradhan B, Kluewer D'Amico J, Makani R, Parikh T
J Trauma Dissociation 2016;17(1):35-54. Epub 2015 Jul 10 doi: 10.1080/15299732.2015.1046101. PMID: 26162001
Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults.
Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C
Cochrane Database Syst Rev 2013 Dec 13;2013(12):CD003388. doi: 10.1002/14651858.CD003388.pub4. PMID: 24338345Free PMC Article
A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U
J Psychopharmacol 2013 Jan;27(1):40-52. Epub 2012 Oct 31 doi: 10.1177/0269881112464827. PMID: 23118021
Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis.
Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S
Br J Psychiatry 2007 Feb;190:97-104. doi: 10.1192/bjp.bp.106.021402. PMID: 17267924

Prognosis

Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.
Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K; PTSD Systems Biology Consortium, Hood L, Doyle FJ 3rd, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett M
Brain Behav Immun 2023 Oct;113:303-316. Epub 2023 Jul 27 doi: 10.1016/j.bbi.2023.07.015. PMID: 37516387
Predictors of Chronic Combat-Related Post-Traumatic Stress Disorder Group Psychotherapy Favorable Outcomes; A Prospective Cohort Study in Croatia.
Cvitanušić S, Britvić D, Filipčić I, Frančišković T
Psychiatr Danub 2022 Fall;34(3):455-463. doi: 10.24869/psyd.2022.455. PMID: 36256983
Theranostic pharmacology in PTSD: Neurobiology and timing.
Koek RJ, Luong TN
Prog Neuropsychopharmacol Biol Psychiatry 2019 Mar 2;90:245-263. Epub 2018 Dec 6 doi: 10.1016/j.pnpbp.2018.12.001. PMID: 30529001
A longitudinal fMRI investigation in acute post-traumatic stress disorder (PTSD).
Ke J, Zhang L, Qi R, Li W, Hou C, Zhong Y, He Z, Li L, Lu G
Acta Radiol 2016 Nov;57(11):1387-1395. Epub 2016 Jul 20 doi: 10.1177/0284185115585848. PMID: 25995310
A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U
J Psychopharmacol 2013 Jan;27(1):40-52. Epub 2012 Oct 31 doi: 10.1177/0269881112464827. PMID: 23118021

Clinical prediction guides

Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder.
Muhie S, Gautam A, Misganaw B, Yang R, Mellon SH, Hoke A, Flory J, Daigle B, Swift K; PTSD Systems Biology Consortium, Hood L, Doyle FJ 3rd, Wolkowitz OM, Marmar CR, Ressler K, Yehuda R, Hammamieh R, Jett M
Brain Behav Immun 2023 Oct;113:303-316. Epub 2023 Jul 27 doi: 10.1016/j.bbi.2023.07.015. PMID: 37516387
Cognitive impairment and World Trade Centre-related exposures.
Clouston SAP, Hall CB, Kritikos M, Bennett DA, DeKosky S, Edwards J, Finch C, Kreisl WC, Mielke M, Peskind ER, Raskind M, Richards M, Sloan RP, Spiro A 3rd, Vasdev N, Brackbill R, Farfel M, Horton M, Lowe S, Lucchini RG, Prezant D, Reibman J, Rosen R, Seil K, Zeig-Owens R, Deri Y, Diminich ED, Fausto BA, Gandy S, Sano M, Bromet EJ, Luft BJ
Nat Rev Neurol 2022 Feb;18(2):103-116. Epub 2021 Nov 18 doi: 10.1038/s41582-021-00576-8. PMID: 34795448Free PMC Article
Symptom profiles and treatment status of older adults with chronic post-traumatic stress disorder.
Rutherford BR, Zilcha-Mano S, Chrisanthopolous M, Salzman C, Zhu C, Cimino N, Yehuda R, Neria Y, Roose SP
Int J Geriatr Psychiatry 2021 Aug;36(8):1216-1222. Epub 2021 Feb 26 doi: 10.1002/gps.5514. PMID: 33577126
A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U
J Psychopharmacol 2013 Jan;27(1):40-52. Epub 2012 Oct 31 doi: 10.1177/0269881112464827. PMID: 23118021
Acute versus chronic post-traumatic stress disorder.
Rahe RH
Integr Physiol Behav Sci 1993 Jan-Mar;28(1):46-56. doi: 10.1007/BF02691199. PMID: 8476741

Recent systematic reviews

Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults.
Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C
Cochrane Database Syst Rev 2013 Dec 13;2013(12):CD003388. doi: 10.1002/14651858.CD003388.pub4. PMID: 24338345Free PMC Article
Early trauma-focused cognitive-behavioural therapy to prevent chronic post-traumatic stress disorder and related symptoms: a systematic review and meta-analysis.
Kornør H, Winje D, Ekeberg Ø, Weisaeth L, Kirkehei I, Johansen K, Steiro A
BMC Psychiatry 2008 Sep 19;8:81. doi: 10.1186/1471-244X-8-81. PMID: 18801204Free PMC Article
Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis.
Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S
Br J Psychiatry 2007 Feb;190:97-104. doi: 10.1192/bjp.bp.106.021402. PMID: 17267924

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