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Diabetic macular edema

MedGen UID:
676494
•Concept ID:
C0730285
•
Disease or Syndrome
Synonyms: diabetic macular edema; Macular edema due to diabetes mellitus
SNOMED CT: Macular edema due to diabetes mellitus (312912001); Diabetic macular edema (312912001)
 
Monarch Initiative: MONDO:0004728

Professional guidelines

PubMed

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy.
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Diabetic macular edema: Evidence-based management.
Browning DJ, Stewart MW, Lee C
Indian J Ophthalmol 2018 Dec;66(12):1736-1750. doi: 10.4103/ijo.IJO_1240_18. PMID: 30451174Free PMC Article
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Faricimab for Diabetic Macular Edema in Patients Refractory to Ranibizumab or Aflibercept.
Ohara H, Harada Y, Hiyama T, Sadahide A, Minamoto A, Kiuchi Y
Medicina (Kaunas) 2023 Jun 11;59(6) doi: 10.3390/medicina59061125. PMID: 37374329Free PMC Article
Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy.
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Diabetic Macular Edema.
Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052
Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861
Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group.
Arch Ophthalmol 1985 Dec;103(12):1796-806. PMID: 2866759

Diagnosis

Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods.
Sorour OA, Levine ES, Baumal CR, Elnahry AG, Braun P, Girgis J, Waheed NK
Surv Ophthalmol 2023 Mar-Apr;68(2):147-174. Epub 2022 Nov 24 doi: 10.1016/j.survophthal.2022.11.008. PMID: 36436614
Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy.
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Diabetic Macular Edema.
Jonas JB
Asia Pac J Ophthalmol (Phila) 2020 Sep-Oct;9(5):377-378. doi: 10.1097/APO.0000000000000324. PMID: 32932292
Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA).
Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, Berg K, Chakravarthy U, Gerendas BS, Jonas J, Larsen M, Tadayoni R, Loewenstein A
Ophthalmologica 2017;237(4):185-222. Epub 2017 Apr 20 doi: 10.1159/000458539. PMID: 28423385
Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales.
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861

Therapy

Optical coherence tomography angiography in diabetic retinopathy.
Waheed NK, Rosen RB, Jia Y, Munk MR, Huang D, Fawzi A, Chong V, Nguyen QD, Sepah Y, Pearce E
Prog Retin Eye Res 2023 Nov;97:101206. Epub 2023 Jul 26 doi: 10.1016/j.preteyeres.2023.101206. PMID: 37499857Free PMC Article
Diabetic Macular Edema and Diode Subthreshold Micropulse Laser: A Randomized Double-Masked Noninferiority Clinical Trial.
Lois N, Campbell C, Waugh N, Azuara-Blanco A, Maredza M, Mistry H, McAuley D, Acharya N, Aslam TM, Bailey C, Chong V, Downey L, Eleftheriadis H, Fatum S, George S, Ghanchi F, Groppe M, Hamilton R, Menon G, Saad A, Sivaprasad S, Shiew M, Steel DH, Talks JS, Doherty P, McDowell C, Clarke M; DIAMONDS Study Group
Ophthalmology 2023 Jan;130(1):14-27. Epub 2022 Aug 13 doi: 10.1016/j.ophtha.2022.08.012. PMID: 35973593
Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema.
Jhaveri CD, Glassman AR, Ferris FL 3rd, Liu D, Maguire MG, Allen JB, Baker CW, Browning D, Cunningham MA, Friedman SM, Jampol LM, Marcus DM, Martin DF, Preston CM, Stockdale CR, Sun JK; DRCR Retina Network
N Engl J Med 2022 Aug 25;387(8):692-703. Epub 2022 Jul 14 doi: 10.1056/NEJMoa2204225. PMID: 35833805Free PMC Article
Laser Therapy in the Treatment of Diabetic Retinopathy and Diabetic Macular Edema.
Everett LA, Paulus YM
Curr Diab Rep 2021 Sep 6;21(9):35. doi: 10.1007/s11892-021-01403-6. PMID: 34487257Free PMC Article
Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema: Two-Year Results from a Comparative Effectiveness Randomized Clinical Trial.
Wells JA, Glassman AR, Ayala AR, Jampol LM, Bressler NM, Bressler SB, Brucker AJ, Ferris FL, Hampton GR, Jhaveri C, Melia M, Beck RW; Diabetic Retinopathy Clinical Research Network
Ophthalmology 2016 Jun;123(6):1351-9. Epub 2016 Feb 27 doi: 10.1016/j.ophtha.2016.02.022. PMID: 26935357Free PMC Article

Prognosis

Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods.
Sorour OA, Levine ES, Baumal CR, Elnahry AG, Braun P, Girgis J, Waheed NK
Surv Ophthalmol 2023 Mar-Apr;68(2):147-174. Epub 2022 Nov 24 doi: 10.1016/j.survophthal.2022.11.008. PMID: 36436614
Five-Year Outcomes after Initial Aflibercept, Bevacizumab, or Ranibizumab Treatment for Diabetic Macular Edema (Protocol T Extension Study).
Glassman AR, Wells JA 3rd, Josic K, Maguire MG, Antoszyk AN, Baker C, Beaulieu WT, Elman MJ, Jampol LM, Sun JK
Ophthalmology 2020 Sep;127(9):1201-1210. Epub 2020 Mar 29 doi: 10.1016/j.ophtha.2020.03.021. PMID: 32402554Free PMC Article
Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.
Gross JG, Glassman AR, Liu D, Sun JK, Antoszyk AN, Baker CW, Bressler NM, Elman MJ, Ferris FL 3rd, Gardner TW, Jampol LM, Martin DF, Melia M, Stockdale CR, Beck RW; Diabetic Retinopathy Clinical Research Network
JAMA Ophthalmol 2018 Oct 1;136(10):1138-1148. doi: 10.1001/jamaophthalmol.2018.3255. PMID: 30043039Free PMC Article
Guidelines on Diabetic Eye Care: The International Council of Ophthalmology Recommendations for Screening, Follow-up, Referral, and Treatment Based on Resource Settings.
Wong TY, Sun J, Kawasaki R, Ruamviboonsuk P, Gupta N, Lansingh VC, Maia M, Mathenge W, Moreker S, Muqit MMK, Resnikoff S, Verdaguer J, Zhao P, Ferris F, Aiello LP, Taylor HR
Ophthalmology 2018 Oct;125(10):1608-1622. Epub 2018 May 24 doi: 10.1016/j.ophtha.2018.04.007. PMID: 29776671
Diabetic Macular Edema.
Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052

Clinical prediction guides

Optical coherence tomography angiography in diabetic retinopathy.
Waheed NK, Rosen RB, Jia Y, Munk MR, Huang D, Fawzi A, Chong V, Nguyen QD, Sepah Y, Pearce E
Prog Retin Eye Res 2023 Nov;97:101206. Epub 2023 Jul 26 doi: 10.1016/j.preteyeres.2023.101206. PMID: 37499857Free PMC Article
Faricimab for Diabetic Macular Edema in Patients Refractory to Ranibizumab or Aflibercept.
Ohara H, Harada Y, Hiyama T, Sadahide A, Minamoto A, Kiuchi Y
Medicina (Kaunas) 2023 Jun 11;59(6) doi: 10.3390/medicina59061125. PMID: 37374329Free PMC Article
Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods.
Sorour OA, Levine ES, Baumal CR, Elnahry AG, Braun P, Girgis J, Waheed NK
Surv Ophthalmol 2023 Mar-Apr;68(2):147-174. Epub 2022 Nov 24 doi: 10.1016/j.survophthal.2022.11.008. PMID: 36436614
Aflibercept versus Faricimab in the Treatment of Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Review.
Liberski S, Wichrowska M, Kocięcki J
Int J Mol Sci 2022 Aug 20;23(16) doi: 10.3390/ijms23169424. PMID: 36012690Free PMC Article
Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR
JAMA 2016 Dec 13;316(22):2402-2410. doi: 10.1001/jama.2016.17216. PMID: 27898976

Recent systematic reviews

Comparative efficacy and safety of Faricimab and other anti-VEGF therapy for age-related macular degeneration and diabetic macular edema: A systematic review and meta-analysis of randomized clinical trials.
Li G, Zhu N, Ji A
Medicine (Baltimore) 2023 Dec 15;102(50):e36370. doi: 10.1097/MD.0000000000036370. PMID: 38115358Free PMC Article
Comparative Efficacy, Durability and Safety of Faricimab in the Treatment of Diabetic Macular Edema: A Systematic Literature Review and Network Meta-Analysis.
Watkins C, Paulo T, Bührer C, Holekamp NM, Bagijn M
Adv Ther 2023 Dec;40(12):5204-5221. Epub 2023 Sep 26 doi: 10.1007/s12325-023-02675-y. PMID: 37751021Free PMC Article
Dyslipidemia and Diabetic Macular Edema: A Systematic Review and Meta-Analysis.
Das R, Kerr R, Chakravarthy U, Hogg RE
Ophthalmology 2015 Sep;122(9):1820-7. Epub 2015 Jul 3 doi: 10.1016/j.ophtha.2015.05.011. PMID: 26150053
Vitrectomy for diabetic macular edema: a systematic review and meta-analysis.
Simunovic MP, Hunyor AP, Ho IV
Can J Ophthalmol 2014 Apr;49(2):188-95. doi: 10.1016/j.jcjo.2013.11.012. PMID: 24767227
Global prevalence and major risk factors of diabetic retinopathy.
Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY; Meta-Analysis for Eye Disease (META-EYE) Study Group
Diabetes Care 2012 Mar;35(3):556-64. Epub 2012 Feb 1 doi: 10.2337/dc11-1909. PMID: 22301125Free PMC Article

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