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Severe nonproliferative diabetic retinopathy

MedGen UID:
676487
•Concept ID:
C0730278
•
Disease or Syndrome
Synonyms: high risk non proliferative diabetic retinopathy; severe nonproliferative diabetic retinopathy; Severe nonproliferative retinopathy; severe nonproliferative retinopathy; Severe nonproliferative retinopathy due to diabetes mellitus; severe npdr; severe NPDR; Severe NPDR (nonproliferative diabetic retinopathy)
SNOMED CT: Severe nonproliferative diabetic retinopathy (312905005); Severe nonproliferative retinopathy (312905005); Severe NPDR (nonproliferative diabetic retinopathy) (312905005); Severe nonproliferative retinopathy due to diabetes mellitus (312905005)
 
Monarch Initiative: MONDO:0004687

Professional guidelines

PubMed

Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients.
Li Y, Ryu C, Munie M, Noorulla S, Rana S, Edwards P, Gao H, Qiao X
J Diabetes Res 2018;2018:2801450. Epub 2018 Apr 30 doi: 10.1155/2018/2801450. PMID: 29854819Free PMC Article
Management of proliferative diabetic retinopathy.
Gündüz K, Bakri SJ
Compr Ophthalmol Update 2007 Sep-Oct;8(5):245-56. PMID: 18201511
Laser treatment in diabetic retinopathy.
Neubauer AS, Ulbig MW
Ophthalmologica 2007;221(2):95-102. doi: 10.1159/000098254. PMID: 17380063

Recent clinical studies

Etiology

The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.
Fang T, Deng X, Wang J, Han F, Liu X, Liu Y, Sun B, Chen L
Front Endocrinol (Lausanne) 2023;14:1288284. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1288284. PMID: 38116309Free PMC Article
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.
Brown DM, Wykoff CC, Boyer D, Heier JS, Clark WL, Emanuelli A, Higgins PM, Singer M, Weinreich DM, Yancopoulos GD, Berliner AJ, Chu K, Reed K, Cheng Y, Vitti R
JAMA Ophthalmol 2021 Sep 1;139(9):946-955. doi: 10.1001/jamaophthalmol.2021.2809. PMID: 34351414Free PMC Article
Correlational Study of Diabetic Retinopathy and Hearing Loss.
Ooley C, Jun W, Le K, Kim A, Rock N, Cardenal M, Kline R, Aldrich D, Hayes J
Optom Vis Sci 2017 Mar;94(3):339-344. doi: 10.1097/OPX.0000000000001025. PMID: 27906862
Management of proliferative diabetic retinopathy.
Gündüz K, Bakri SJ
Compr Ophthalmol Update 2007 Sep-Oct;8(5):245-56. PMID: 18201511
Screening for and managing diabetic retinopathy: current approaches.
Bloomgarden ZT
Am J Health Syst Pharm 2007 Sep 1;64(17 Suppl 12):S8-14. doi: 10.2146/ajhp070331. PMID: 17720893

Diagnosis

The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.
Fang T, Deng X, Wang J, Han F, Liu X, Liu Y, Sun B, Chen L
Front Endocrinol (Lausanne) 2023;14:1288284. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1288284. PMID: 38116309Free PMC Article
Risk Factors and Outcomes of Delayed Presentation of Diabetic Retinopathy Patients to a County Hospital.
Lu VI, Patnaik JL, Scott RA, Lynch AM, Smith JM, Mandava N, Manoharan N
Transl Vis Sci Technol 2023 Sep 1;12(9):8. doi: 10.1167/tvst.12.9.8. PMID: 37676677Free PMC Article
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.
Brown DM, Wykoff CC, Boyer D, Heier JS, Clark WL, Emanuelli A, Higgins PM, Singer M, Weinreich DM, Yancopoulos GD, Berliner AJ, Chu K, Reed K, Cheng Y, Vitti R
JAMA Ophthalmol 2021 Sep 1;139(9):946-955. doi: 10.1001/jamaophthalmol.2021.2809. PMID: 34351414Free PMC Article
Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes.
Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux EL, Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY
JAMA 2017 Dec 12;318(22):2211-2223. doi: 10.1001/jama.2017.18152. PMID: 29234807Free PMC Article
Screening for and managing diabetic retinopathy: current approaches.
Bloomgarden ZT
Am J Health Syst Pharm 2007 Sep 1;64(17 Suppl 12):S8-14. doi: 10.2146/ajhp070331. PMID: 17720893

Therapy

Intraretinal Hyper-Reflective Foci Are Almost Universally Present and Co-Localize With Intraretinal Fluid in Diabetic Macular Edema.
von Schulthess EL, Maunz A, Chakravarthy U, Holekamp N, Pauleikhoff D, Patel K, Bachmeier I, Yu S, Cohen Y, Scherb MP, Jones IL, Gibson K, Willis JR, Glittenberg C, Singh RP, Fauser S
Invest Ophthalmol Vis Sci 2024 May 1;65(5):26. doi: 10.1167/iovs.65.5.26. PMID: 38758639Free PMC Article
The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.
Fang T, Deng X, Wang J, Han F, Liu X, Liu Y, Sun B, Chen L
Front Endocrinol (Lausanne) 2023;14:1288284. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1288284. PMID: 38116309Free PMC Article
Evaluating the Effect of Hypoglycemic Agents on Diabetic Retinopathy Progression.
Wai KM, Saroj N, Boucher N, Aggarwal N, Ho AC, Rahimy E
Ophthalmic Surg Lasers Imaging Retina 2023 Mar;54(3):158-165. Epub 2023 Mar 1 doi: 10.3928/23258160-20230217-02. PMID: 36944068
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.
Brown DM, Wykoff CC, Boyer D, Heier JS, Clark WL, Emanuelli A, Higgins PM, Singer M, Weinreich DM, Yancopoulos GD, Berliner AJ, Chu K, Reed K, Cheng Y, Vitti R
JAMA Ophthalmol 2021 Sep 1;139(9):946-955. doi: 10.1001/jamaophthalmol.2021.2809. PMID: 34351414Free PMC Article
Association of Plasma Semaphorin 3A With Phenotypes of Diabetic Retinopathy and Nephropathy.
Kwon SH, Shin JP, Kim IT, Park DH
Invest Ophthalmol Vis Sci 2016 Jun 1;57(7):2983-9. doi: 10.1167/iovs.16-19468. PMID: 27273597

Prognosis

Four-Year Screening Interval and Vision-Threatening Retinopathy in Type 2 Diabetes Patients With Good Glycemic Control.
Tsujimoto T, Kajio H
Mayo Clin Proc 2021 Feb;96(2):322-331. doi: 10.1016/j.mayocp.2020.07.031. PMID: 33549254
Peripapillary Retinal Nerve Fiber Layer Changes in Patients with Diabetes Mellitus: A Case-control Study.
Chatziralli I, Karamaounas A, Dimitriou E, Kazantzis D, Theodossiadis G, Kozobolis V, Theodossiadis P
Semin Ophthalmol 2020 May 18;35(4):257-260. Epub 2020 Aug 22 doi: 10.1080/08820538.2020.1810289. PMID: 32835571
Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes.
DCCT/EDIC Research Group, Nathan DM, Bebu I, Hainsworth D, Klein R, Tamborlane W, Lorenzi G, Gubitosi-Klug R, Lachin JM
N Engl J Med 2017 Apr 20;376(16):1507-1516. doi: 10.1056/NEJMoa1612836. PMID: 28423305Free PMC Article
Pentosidine and N-carboxymethyl-lysine: biomarkers for type 2 diabetic retinopathy.
Ghanem AA, Elewa A, Arafa LF
Eur J Ophthalmol 2011 Jan-Feb;21(1):48-54. doi: 10.5301/ejo.2010.4447. PMID: 20544678
Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis.
Nguyen TT, Alibrahim E, Islam FM, Klein R, Klein BE, Cotch MF, Shea S, Wong TY
Diabetes Care 2009 Sep;32(9):1704-9. Epub 2009 Jun 23 doi: 10.2337/dc09-0102. PMID: 19549733Free PMC Article

Clinical prediction guides

Intraretinal Hyper-Reflective Foci Are Almost Universally Present and Co-Localize With Intraretinal Fluid in Diabetic Macular Edema.
von Schulthess EL, Maunz A, Chakravarthy U, Holekamp N, Pauleikhoff D, Patel K, Bachmeier I, Yu S, Cohen Y, Scherb MP, Jones IL, Gibson K, Willis JR, Glittenberg C, Singh RP, Fauser S
Invest Ophthalmol Vis Sci 2024 May 1;65(5):26. doi: 10.1167/iovs.65.5.26. PMID: 38758639Free PMC Article
The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.
Fang T, Deng X, Wang J, Han F, Liu X, Liu Y, Sun B, Chen L
Front Endocrinol (Lausanne) 2023;14:1288284. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1288284. PMID: 38116309Free PMC Article
Four-Year Screening Interval and Vision-Threatening Retinopathy in Type 2 Diabetes Patients With Good Glycemic Control.
Tsujimoto T, Kajio H
Mayo Clin Proc 2021 Feb;96(2):322-331. doi: 10.1016/j.mayocp.2020.07.031. PMID: 33549254
Erectile dysfunction is associated with severe retinopathy in diabetic men.
Henis O, Shahar Y, Steinvil A, Finn T, Heruti R, Loewenstein A, Justo D
Urology 2011 May;77(5):1133-6. doi: 10.1016/j.urology.2011.01.009. PMID: 21539963
Pentosidine and N-carboxymethyl-lysine: biomarkers for type 2 diabetic retinopathy.
Ghanem AA, Elewa A, Arafa LF
Eur J Ophthalmol 2011 Jan-Feb;21(1):48-54. doi: 10.5301/ejo.2010.4447. PMID: 20544678

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