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Serpiginous choroiditis

MedGen UID:
152674
Concept ID:
C0729842
Disease or Syndrome
Synonyms: Geographic choroiditis; Geographic helicoid peripapillary choroidopathy (GHPC); Geographic serpiginous choroiditis; Peripapillary choriopathy; Serpiginous choroidopathy
SNOMED CT: Serpiginous choroidal dystrophy (312491004); Serpiginous choroiditis (312491004); Serpiginous choroidopathy (312491004)
 
Monarch Initiative: MONDO:0018152
Orphanet: ORPHA35686

Definition

A rare non-infectious posterior uveitis characterized by usually bilateral, chronic, progressive, recurrent inflammation of the choroid, retinal pigment epithelium, and choriocapillaris. In the classic or peripapillary geographic type of the disease, infiltrates originating in the peripapillary region progress in an irregular serpentine fashion centrifugally and resolve spontaneously after several weeks, leaving atrophic scars. Multiple recurrences, often with months to years of quiescence in between, result in progressive visual loss in one or both eyes. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerpiginous choroiditis
Follow this link to review classifications for Serpiginous choroiditis in Orphanet.

Professional guidelines

PubMed

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:126-133. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.038. PMID: 33845013Free PMC Article
Bansal R, Gupta A, Gupta V
Int Ophthalmol Clin 2012 Fall;52(4):229-36. doi: 10.1097/IIO.0b013e318265d474. PMID: 22954945

Recent clinical studies

Etiology

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Brar M, Sharma M, Grewal S, Grewal D, Dogra MR
Eur J Ophthalmol 2022 May;32(3):1555-1561. Epub 2021 Jun 27 doi: 10.1177/11206721211028529. PMID: 34180265
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:126-133. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.038. PMID: 33845013Free PMC Article
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832
Quillen DA, Davis JB, Gottlieb JL, Blodi BA, Callanan DG, Chang TS, Equi RA
Am J Ophthalmol 2004 Mar;137(3):538-50. doi: 10.1016/j.ajo.2004.01.053. PMID: 15013878

Diagnosis

Saleh M
J Fr Ophtalmol 2020 Feb;43(2):e55-e66. Epub 2020 Jan 10 doi: 10.1016/j.jfo.2019.12.001. PMID: 31932062
Dutta Majumder P, Biswas J, Gupta A
Indian J Ophthalmol 2019 Mar;67(3):325-333. doi: 10.4103/ijo.IJO_822_18. PMID: 30777946Free PMC Article
Nazari Khanamiri H, Rao NA
Surv Ophthalmol 2013 May-Jun;58(3):203-32. Epub 2013 Mar 27 doi: 10.1016/j.survophthal.2012.08.008. PMID: 23541041Free PMC Article
Tabbara KF
Curr Opin Ophthalmol 2007 Nov;18(6):493-501. doi: 10.1097/ICU.0b013e3282f06d2e. PMID: 18163002
Lim WK, Buggage RR, Nussenblatt RB
Surv Ophthalmol 2005 May-Jun;50(3):231-44. doi: 10.1016/j.survophthal.2005.02.010. PMID: 15850812

Therapy

Ahmed AH, Kubaisi B, Foster CS
JAMA Ophthalmol 2017 Apr 13;135(4):e165495. doi: 10.1001/jamaophthalmol.2016.5495. PMID: 28418567
Nazari Khanamiri H, Rao NA
Surv Ophthalmol 2013 May-Jun;58(3):203-32. Epub 2013 Mar 27 doi: 10.1016/j.survophthal.2012.08.008. PMID: 23541041Free PMC Article
Lim WK, Buggage RR, Nussenblatt RB
Surv Ophthalmol 2005 May-Jun;50(3):231-44. doi: 10.1016/j.survophthal.2005.02.010. PMID: 15850812
Ciulla TA, Gragoudas ES
Int Ophthalmol Clin 1996 Winter;36(1):135-43. doi: 10.1097/00004397-199603610-00014. PMID: 8778059
Laatikainen L, Erkkilä H
Br J Ophthalmol 1974 Sep;58(9):777-83. doi: 10.1136/bjo.58.9.777. PMID: 4433491Free PMC Article

Prognosis

Saleh M
J Fr Ophtalmol 2020 Feb;43(2):e55-e66. Epub 2020 Jan 10 doi: 10.1016/j.jfo.2019.12.001. PMID: 31932062
Tabbara KF
Curr Opin Ophthalmol 2007 Nov;18(6):493-501. doi: 10.1097/ICU.0b013e3282f06d2e. PMID: 18163002
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832
Lim WK, Buggage RR, Nussenblatt RB
Surv Ophthalmol 2005 May-Jun;50(3):231-44. doi: 10.1016/j.survophthal.2005.02.010. PMID: 15850812
Quillen DA, Davis JB, Gottlieb JL, Blodi BA, Callanan DG, Chang TS, Equi RA
Am J Ophthalmol 2004 Mar;137(3):538-50. doi: 10.1016/j.ajo.2004.01.053. PMID: 15013878

Clinical prediction guides

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Brar M, Sharma M, Grewal S, Grewal D, Dogra MR
Eur J Ophthalmol 2022 May;32(3):1555-1561. Epub 2021 Jun 27 doi: 10.1177/11206721211028529. PMID: 34180265
Khan HA, Shahzad MA, Iqbal F, Awan MA, Sharjeel M, Khan QA, Rashid F, Abbas A, Khan AA, Rehman MU, Khan N, Pizzimenti J, Mehmood A
Ocul Immunol Inflamm 2022 Feb 17;30(2):417-423. Epub 2020 Aug 18 doi: 10.1080/09273948.2020.1800047. PMID: 32809905
Wang XN, You QS, Zhao HY, Peng XY
Biomed Environ Sci 2018 May;31(5):327-334. doi: 10.3967/bes2018.043. PMID: 29866214
Baarsma GS, Deutman AF
Doc Ophthalmol 1976 Mar 31;40(2):269-85. doi: 10.1007/BF00155041. PMID: 1269358

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