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Pulmonary amyloidosis

MedGen UID:
675153
Concept ID:
C0700376
Disease or Syndrome
Synonym: pulmonary amyloidosis
SNOMED CT: Pulmonary amyloidosis (196135008)
 
HPO: HP:0033247
Monarch Initiative: MONDO:0800127

Definition

Extracellular deposition in lung tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary amyloidosis

Professional guidelines

PubMed

Johnson SR, Shaw DE, Avoseh M, Soomro I, Pointon KS, Kokosi M, Nicholson AG, Desai SR, George PM
Thorax 2024 Mar 15;79(4):366-377. doi: 10.1136/thorax-2022-219738. PMID: 38182428
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Recent clinical studies

Etiology

Eggleston RH, Hartman TE, Walkoff LA, Yi ES, Ryu JH, Baqir M
Respir Med 2022 Apr;194:106761. Epub 2022 Feb 8 doi: 10.1016/j.rmed.2022.106761. PMID: 35217402
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Diagnosis

Kinoshita Y, Ikeda T, Miyamura T, Ueda Y, Yoshida Y, Ueda M, Haraoka S, Kushima H, Ishii H
Intern Med 2022 Mar 15;61(6):877-881. Epub 2021 Aug 31 doi: 10.2169/internalmedicine.8169-21. PMID: 34471033Free PMC Article
Guasch M, Ojanguren A, Gómez JR
Cir Esp (Engl Ed) 2020 Jan;98(1):50-52. Epub 2019 Jun 13 doi: 10.1016/j.ciresp.2019.03.008. PMID: 31204007
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Therapy

Bhandari BS, Rana G, Jani P
Arch Bronconeumol 2023 Jul;59(7):452. Epub 2023 May 23 doi: 10.1016/j.arbres.2023.05.008. PMID: 37277256
Higo H, Fujiwara K, Watanabe H, Makimoto G, Kameyama N, Matsushita M, Rai K, Sato K, Inomata T, Sunami K, Shibayama T
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Iwasaki T, Hamano T, Aizawa K, Kobayashi K, Kakishita E
Acta Haematol 1994;91(2):91-4. doi: 10.1159/000204262. PMID: 8023651

Prognosis

Johnson SR, Shaw DE, Avoseh M, Soomro I, Pointon KS, Kokosi M, Nicholson AG, Desai SR, George PM
Thorax 2024 Mar 15;79(4):366-377. doi: 10.1136/thorax-2022-219738. PMID: 38182428
Riehani A, Soubani AO
Respir Med 2023 Nov;218:107407. Epub 2023 Sep 9 doi: 10.1016/j.rmed.2023.107407. PMID: 37696313
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Eur Respir Rev 2017 Sep 30;26(145) Epub 2017 Sep 6 doi: 10.1183/16000617.0046-2017. PMID: 28877975Free PMC Article
Iwasaki T, Hamano T, Aizawa K, Kobayashi K, Kakishita E
Acta Haematol 1994;91(2):91-4. doi: 10.1159/000204262. PMID: 8023651
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Chest 1986 Dec;90(6):790-1. doi: 10.1378/chest.90.6.790. PMID: 3780324

Clinical prediction guides

Kawashiri SY, Tamai M, Yamasaki S, Nakamura H, Kakugawa T, Sakamoto N, Ishimatsu Y, Kawakami A
Mod Rheumatol 2011 Dec;21(6):646-50. Epub 2011 Mar 25 doi: 10.1007/s10165-011-0443-6. PMID: 21437616
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Iwasaki T, Hamano T, Aizawa K, Kobayashi K, Kakishita E
Acta Haematol 1994;91(2):91-4. doi: 10.1159/000204262. PMID: 8023651
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Recent systematic reviews

Liu Y, Jin Z, Zhang H, Zhang Y, Shi M, Meng F, Sun Q, Cai H
BMC Cancer 2018 Aug 8;18(1):802. doi: 10.1186/s12885-018-4565-5. PMID: 30089469Free PMC Article
Rajagopala S, Singh N, Gupta K, Gupta D
Respirology 2010 Jul;15(5):860-6. Epub 2010 Jun 4 doi: 10.1111/j.1440-1843.2010.01772.x. PMID: 20546191

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