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Smokeless tobacco keratosis

MedGen UID:
672839
•Concept ID:
C0685919
•
Disease or Syndrome
Synonym: Smokeless tobacco hyperkeratosis
SNOMED CT: Smokeless tobacco keratosis (95269005); Smokeless tobacco hyperkeratosis (95269005)

Definition

A white mucosal lesion in the area of the mouth where there has been tobacco contact. The lesion develops as a result of habitual chewing of tobacco or use of snuff tobacco. The lesion is premalignant. [from SNOMEDCT_US]

Professional guidelines

PubMed

White lesions in the oral cavity: clinical presentation, diagnosis, and treatment.
Jones KB, Jordan R
Semin Cutan Med Surg 2015 Dec;34(4):161-70. doi: 10.12788/j.sder.2015.0180. PMID: 26650693

Recent clinical studies

Etiology

Smokeless tobacco keratosis in oral mucosa with epithelial dysplasia: A case report.
Kaabi HH
Medicine (Baltimore) 2024 Apr 12;103(15):e37771. doi: 10.1097/MD.0000000000037771. PMID: 38608125Free PMC Article
Is p16(INK4a) protein expression in oral ST lesions a reliable precancerous marker?
Greer RO Jr, Meyers A, Said SM, Shroyer KR
Int J Oral Maxillofac Surg 2008 Sep;37(9):840-6. Epub 2008 Jul 7 doi: 10.1016/j.ijom.2008.05.015. PMID: 18606525
Oral changes associated with tobacco use.
Taybos G
Am J Med Sci 2003 Oct;326(4):179-82. doi: 10.1097/00000441-200310000-00005. PMID: 14557730
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882

Diagnosis

Smokeless tobacco keratosis in oral mucosa with epithelial dysplasia: A case report.
Kaabi HH
Medicine (Baltimore) 2024 Apr 12;103(15):e37771. doi: 10.1097/MD.0000000000037771. PMID: 38608125Free PMC Article
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.
Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762Free PMC Article
White lesions in the oral cavity: clinical presentation, diagnosis, and treatment.
Jones KB, Jordan R
Semin Cutan Med Surg 2015 Dec;34(4):161-70. doi: 10.12788/j.sder.2015.0180. PMID: 26650693
Is p16(INK4a) protein expression in oral ST lesions a reliable precancerous marker?
Greer RO Jr, Meyers A, Said SM, Shroyer KR
Int J Oral Maxillofac Surg 2008 Sep;37(9):840-6. Epub 2008 Jul 7 doi: 10.1016/j.ijom.2008.05.015. PMID: 18606525
Case #6. Smokeless tobacco keratosis.
Haring JI
RDH 1993 Jun;13(6):10, 12. PMID: 8234877

Therapy

Smokeless tobacco keratosis in oral mucosa with epithelial dysplasia: A case report.
Kaabi HH
Medicine (Baltimore) 2024 Apr 12;103(15):e37771. doi: 10.1097/MD.0000000000037771. PMID: 38608125Free PMC Article
Smokeless tobacco keratosis.
Petruzzelli CJ, Varano A, Desrosiers A, Hossler EW, Mowad CM
Dermatol Online J 2023 Jun 15;29(3) doi: 10.5070/D329361430. PMID: 37591270
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.
Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762Free PMC Article
Oral changes associated with tobacco use.
Taybos G
Am J Med Sci 2003 Oct;326(4):179-82. doi: 10.1097/00000441-200310000-00005. PMID: 14557730
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882

Prognosis

Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882
Oral leukoplakia and erythroplakia: a review and update.
Bouquot JE
Pract Periodontics Aesthet Dent 1994 Aug;6(6):9-17; quiz 19. PMID: 7833463

Clinical prediction guides

Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882
Oral leukoplakia and erythroplakia: a review and update.
Bouquot JE
Pract Periodontics Aesthet Dent 1994 Aug;6(6):9-17; quiz 19. PMID: 7833463

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