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Morphine Abuse

MedGen UID:
154673
•Concept ID:
C0600272
•
Mental or Behavioral Dysfunction
Synonym: Abuse, Morphine

Professional guidelines

PubMed

Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain.
Fanelli A, Sorella MC, Ghisi D
Expert Rev Clin Pharmacol 2018 Dec;11(12):1157-1162. Epub 2018 Nov 17 doi: 10.1080/17512433.2018.1545573. PMID: 30403896

Recent clinical studies

Etiology

The α(1) adrenoceptor antagonist prazosin potentiates morphine induced conditioned place preference in rats.
Tu W, Zhang T, Li C, Jia W, Yao Z, Yi S, Chen H, Liu Y, Zhou D, Wang C, Zhang R, Shi Z, Yuan T, Zhao B, Wei L
Brain Res 2023 Dec 15;1821:148614. Epub 2023 Sep 30 doi: 10.1016/j.brainres.2023.148614. PMID: 37783262
Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains.
Soto-Montenegro ML, García-Vázquez V, Lamanna-Rama N, López-Montoya G, Desco M, Ambrosio E
Sci Rep 2022 Mar 17;12(1):4643. doi: 10.1038/s41598-022-08698-9. PMID: 35301397Free PMC Article
The effects of morphine abuse on sperm parameters, chromatin integrity and apoptosis in men.
Ghasemi-Esmailabad S, Talebi AH, Talebi AR, Amiri S, Moshrefi M, Pourentezari M
JBRA Assist Reprod 2022 Aug 4;26(3):444-449. doi: 10.5935/1518-0557.20210110. PMID: 34995046Free PMC Article
Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users.
Smith MD, Webster LR, Lawler J, Lindhardt K, Dayno JM
Pain Med 2017 May 1;18(5):898-907. doi: 10.1093/pm/pnw174. PMID: 27633773Free PMC Article
Time-dependent effect of oral morphine consumption on the development of cytotrophoblast and syncytiotrophoblast cells of the placental layers during the three different periods of pregnancy in Wistar rats.
Dehghani L, Sahraei H, Meamar R, Kazemi M
Clin Dev Immunol 2013;2013:974205. Epub 2013 Mar 3 doi: 10.1155/2013/974205. PMID: 23533457Free PMC Article

Diagnosis

Codeine influences the serum and urinary profile of endogenous androgens but does not interact with the excretion rate of administered testosterone.
Lehtihet M, Andersson A, Börjesson A, Schulze J, Rane A, Ericsson M, Ekström L
Drug Test Anal 2018 Apr;10(4):723-730. Epub 2017 Nov 13 doi: 10.1002/dta.2301. PMID: 28901724
The ALERRT(®) instrument: a quantitative measure of the effort required to compromise prescription opioid abuse-deterrent tablets.
Cone EJ, Buchhalter AR, Lindhardt K, Elhauge T, Dayno JM
Am J Drug Alcohol Abuse 2017 May;43(3):291-298. Epub 2017 Feb 13 doi: 10.1080/00952990.2016.1278006. PMID: 28448223
Hair testing in postmortem diagnosis of substance abuse: An unusual case of slow-release oral morphine abuse in an adolescent.
Baillif-Couniou V, Kintz P, Sastre C, Pok PR, Chèze M, Pépin G, Leonetti G, Pelissier-Alicot AL
J Forensic Leg Med 2015 Nov;36:172-6. Epub 2015 Sep 4 doi: 10.1016/j.jflm.2015.08.014. PMID: 26492165
Acute morphine and cocaine related death after trimethoprim-adultered cocaine abuse.
Fucci N, Pascali VL
Ann Clin Lab Sci 2014 Fall;44(4):499-501. PMID: 25361939
The determination of morphine in urine and oral fluid following ingestion of poppy seeds.
Rohrig TP, Moore C
J Anal Toxicol 2003 Oct;27(7):449-52. doi: 10.1093/jat/27.7.449. PMID: 14606998

Therapy

Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse.
Alizamini MM, Li Y, Zhang JJ, Liang J, Haghparast A
World J Biol Psychiatry 2022 Dec;23(10):743-763. Epub 2022 Mar 4 doi: 10.1080/15622975.2022.2039408. PMID: 35137652
Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain.
Fanelli A, Sorella MC, Ghisi D
Expert Rev Clin Pharmacol 2018 Dec;11(12):1157-1162. Epub 2018 Nov 17 doi: 10.1080/17512433.2018.1545573. PMID: 30403896
Human abuse potential studies of abuse-deterrent opioids: lessons from oral and intranasal studies with morphine abuse-deterrent, extended-release, injection-molded tablets.
Webster LR, Viscusi ER, Brown C, Dayno JM
Curr Med Res Opin 2018 May;34(5):893-901. Epub 2018 Feb 8 doi: 10.1080/03007995.2018.1433144. PMID: 29368961
Abuse-deterrent features of an extended-release morphine drug product developed using a novel injection-molding technology for oral drug delivery.
Skak N, Elhauge T, Dayno JM, Lindhardt K
J Opioid Manag 2017 Nov/Dec;13(6):465-472. doi: 10.5055/jom.2017.0406. PMID: 29308592
Epidemiological trends and the advances of treatments of amphetamine-type stimulants (ATS) in China.
Sun HQ, Chen HM, Yang FD, Lu L, Kosten TR
Am J Addict 2014 May-Jun;23(3):313-7. doi: 10.1111/j.1521-0391.2014.12116.x. PMID: 24724890

Clinical prediction guides

Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains.
Soto-Montenegro ML, García-Vázquez V, Lamanna-Rama N, López-Montoya G, Desco M, Ambrosio E
Sci Rep 2022 Mar 17;12(1):4643. doi: 10.1038/s41598-022-08698-9. PMID: 35301397Free PMC Article
The ALERRT(®) instrument: a quantitative measure of the effort required to compromise prescription opioid abuse-deterrent tablets.
Cone EJ, Buchhalter AR, Lindhardt K, Elhauge T, Dayno JM
Am J Drug Alcohol Abuse 2017 May;43(3):291-298. Epub 2017 Feb 13 doi: 10.1080/00952990.2016.1278006. PMID: 28448223
Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) vs Extended-Release Morphine Administered Intranasally in Nondependent Recreational Opioid Users.
Webster LR, Smith MD, Lawler J, Lindhardt K, Dayno JM
Pain Med 2017 Sep 1;18(9):1695-1705. doi: 10.1093/pm/pnw219. PMID: 27651510Free PMC Article
Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users.
Smith MD, Webster LR, Lawler J, Lindhardt K, Dayno JM
Pain Med 2017 May 1;18(5):898-907. doi: 10.1093/pm/pnw174. PMID: 27633773Free PMC Article
Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: a prospective study in methadone, heroin, codeine and morphine addicts.
Hensel M, Kox WJ
Acta Anaesthesiol Scand 2000 Mar;44(3):326-33. doi: 10.1034/j.1399-6576.2000.440319.x. PMID: 10714849

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