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Cutaneous hypersensitivity

MedGen UID:
667534
•Concept ID:
C0585186
•
Disease or Syndrome
Synonyms: Allergic disorder of skin; Allergic skin rash; Cutaneous allergy; Skin allergy; Skin hypersensitivity
SNOMED CT: Allergic disorder of skin (422290000); Skin allergy (422290000); Cutaneous hypersensitivity (21626009); Skin hypersensitivity (21626009); Cutaneous allergy (21626009); Allergic skin rash (21626009)

Definition

state of altered reactivity in which the body reacts with an exaggerated or inappropriate immune response to a chemical substance having the properties of an antigen or hapten that is in contact with the skin, the resulting skin condition being allergic contact dermatitis. [from CRISP]

Professional guidelines

PubMed

Delayed Cutaneous Hypersensitivity Reactions to Antibiotics: Management with Desensitization.
McNulty CMG, Park MA
Immunol Allergy Clin North Am 2017 Nov;37(4):751-760. doi: 10.1016/j.iac.2017.07.002. PMID: 28965638
Current management of gout in patients unresponsive or allergic to allopurinol.
Bardin T
Joint Bone Spine 2004 Nov;71(6):481-5. doi: 10.1016/j.jbspin.2004.07.006. PMID: 15589427
Mycosis fungoides: management with topical nitrogen mustard.
Hoppe RT, Abel EA, Deneau DG, Price NM
J Clin Oncol 1987 Nov;5(11):1796-803. doi: 10.1200/JCO.1987.5.11.1796. PMID: 3681368

Recent clinical studies

Etiology

Ear-piercing complications in children and adolescents.
Kim MM, Goldman RD
Can Fam Physician 2022 Sep;68(9):661-663. doi: 10.46747/cfp.6809661. PMID: 36100383Free PMC Article
Therapeutic use of heparin beyond anticoagulation.
Ludwig RJ
Curr Drug Discov Technol 2009 Dec;6(4):281-9. doi: 10.2174/157016309789869001. PMID: 20025596
Icodextrin: a review of its use in peritoneal dialysis.
Frampton JE, Plosker GL
Drugs 2003;63(19):2079-105. doi: 10.2165/00003495-200363190-00011. PMID: 12962523
Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis.
Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G
Chest 2002 Apr;121(4):1239-44. doi: 10.1378/chest.121.4.1239. PMID: 11948059
Nutritional modulation of intestinal mucosal immunity.
Chandra RK, Wadhwa M
Immunol Invest 1989 Jan-May;18(1-4):119-26. doi: 10.3109/08820138909112232. PMID: 2659508

Diagnosis

Chemical characterization of inks in skin reactions to tattoo.
Colboc H, Bazin D, Reguer S, Lucas IT, Moguelet P, Amode R, Jouanneau C, Soria A, Chasset F, Amsler E, Pecquet C, Aractingi S, Bellot-Gurlet L, Deschamps L, Descamps V, Kluger N
J Synchrotron Radiat 2022 Nov 1;29(Pt 6):1436-1445. Epub 2022 Oct 4 doi: 10.1107/S1600577522008165. PMID: 36345752Free PMC Article
Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination.
Larson V, Seidenberg R, Caplan A, Brinster NK, Meehan SA, Kim RH
J Cutan Pathol 2022 Jan;49(1):34-41. Epub 2021 Aug 8 doi: 10.1111/cup.14104. PMID: 34292611Free PMC Article
Protein Causes of Urticaria and Dermatitis.
Ashbaugh AG, Abel MK, Murase JE
Immunol Allergy Clin North Am 2021 Aug;41(3):481-491. Epub 2021 Jun 5 doi: 10.1016/j.iac.2021.04.008. PMID: 34225902
Urticaria multiforme--a case report.
Starnes L, Patel T, Skinner RB
Pediatr Dermatol 2011 Jul-Aug;28(4):436-8. doi: 10.1111/j.1525-1470.2011.01311.x. PMID: 21793883
Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis.
Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G
Chest 2002 Apr;121(4):1239-44. doi: 10.1378/chest.121.4.1239. PMID: 11948059

Therapy

Teprotumumab-related Cutaneous Hypersensitivity Reactions.
Dallalzadeh LO, Ting M, Topilow N, Robbins SL, Liu CY, Burkat CN, Korn BS, Kikkawa DO
Ophthalmic Plast Reconstr Surg 2023 Nov-Dec 01;39(6):e208-e210. Epub 2023 Sep 1 doi: 10.1097/IOP.0000000000002482. PMID: 37656913
Chemical characterization of inks in skin reactions to tattoo.
Colboc H, Bazin D, Reguer S, Lucas IT, Moguelet P, Amode R, Jouanneau C, Soria A, Chasset F, Amsler E, Pecquet C, Aractingi S, Bellot-Gurlet L, Deschamps L, Descamps V, Kluger N
J Synchrotron Radiat 2022 Nov 1;29(Pt 6):1436-1445. Epub 2022 Oct 4 doi: 10.1107/S1600577522008165. PMID: 36345752Free PMC Article
Ear-piercing complications in children and adolescents.
Kim MM, Goldman RD
Can Fam Physician 2022 Sep;68(9):661-663. doi: 10.46747/cfp.6809661. PMID: 36100383Free PMC Article
Therapeutic use of heparin beyond anticoagulation.
Ludwig RJ
Curr Drug Discov Technol 2009 Dec;6(4):281-9. doi: 10.2174/157016309789869001. PMID: 20025596
Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests.
Naisbitt DJ
Toxicology 2004 Jan 15;194(3):179-96. doi: 10.1016/j.tox.2003.09.004. PMID: 14687965

Prognosis

Teprotumumab-related Cutaneous Hypersensitivity Reactions.
Dallalzadeh LO, Ting M, Topilow N, Robbins SL, Liu CY, Burkat CN, Korn BS, Kikkawa DO
Ophthalmic Plast Reconstr Surg 2023 Nov-Dec 01;39(6):e208-e210. Epub 2023 Sep 1 doi: 10.1097/IOP.0000000000002482. PMID: 37656913
Protein Causes of Urticaria and Dermatitis.
Ashbaugh AG, Abel MK, Murase JE
Immunol Allergy Clin North Am 2021 Aug;41(3):481-491. Epub 2021 Jun 5 doi: 10.1016/j.iac.2021.04.008. PMID: 34225902
Urticaria multiforme--a case report.
Starnes L, Patel T, Skinner RB
Pediatr Dermatol 2011 Jul-Aug;28(4):436-8. doi: 10.1111/j.1525-1470.2011.01311.x. PMID: 21793883
Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests.
Naisbitt DJ
Toxicology 2004 Jan 15;194(3):179-96. doi: 10.1016/j.tox.2003.09.004. PMID: 14687965
Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis.
Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G
Chest 2002 Apr;121(4):1239-44. doi: 10.1378/chest.121.4.1239. PMID: 11948059

Clinical prediction guides

Teprotumumab-related Cutaneous Hypersensitivity Reactions.
Dallalzadeh LO, Ting M, Topilow N, Robbins SL, Liu CY, Burkat CN, Korn BS, Kikkawa DO
Ophthalmic Plast Reconstr Surg 2023 Nov-Dec 01;39(6):e208-e210. Epub 2023 Sep 1 doi: 10.1097/IOP.0000000000002482. PMID: 37656913
Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests.
Naisbitt DJ
Toxicology 2004 Jan 15;194(3):179-96. doi: 10.1016/j.tox.2003.09.004. PMID: 14687965
Nutritional modulation of intestinal mucosal immunity.
Chandra RK, Wadhwa M
Immunol Invest 1989 Jan-May;18(1-4):119-26. doi: 10.3109/08820138909112232. PMID: 2659508
Immunological aspects of gastritis and pernicious anaemia.
Kaye MD
Baillieres Clin Gastroenterol 1987 Jul;1(3):487-506. doi: 10.1016/0950-3528(87)90044-3. PMID: 3322429
Cell-mediated immunity in nutritional deficiency.
McMurray DN
Prog Food Nutr Sci 1984;8(3-4):193-228. PMID: 6396715

Recent systematic reviews

Impact of sesquiterpene lactones on the skin and skin-related cells? A systematic review of in vitro and in vivo evidence.
da Silva LP, Borges BA, Veloso MP, Chagas-Paula DA, Gonçalves RV, Novaes RD
Life Sci 2021 Jan 15;265:118815. Epub 2020 Dec 2 doi: 10.1016/j.lfs.2020.118815. PMID: 33278385
Skin Allergy to Azole Antifungal Agents for Systemic Use: A Review of the Literature.
Calogiuri G, Garvey LH, Nettis E, Romita P, Di Leo E, Caruso R, Butani L, Foti C
Recent Pat Inflamm Allergy Drug Discov 2019;13(2):144-157. doi: 10.2174/1872213X13666190919162414. PMID: 31538908
Cutaneous Hypersensitivity-Like Reactions Associated With Breast Implants: A Review.
Labadie JG, Korta DZ, Barton N, Mesinkovska NA
Dermatol Surg 2018 Mar;44(3):323-329. doi: 10.1097/DSS.0000000000001448. PMID: 29293108
A systematic review of published literature describing factors associated with tuberculosis recurrence in people living with HIV in Africa.
Moodley Y, Govender K
Afr Health Sci 2015 Dec;15(4):1239-46. doi: 10.4314/ahs.v15i4.24. PMID: 26958026Free PMC Article

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