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Lower urinary tract symptoms

MedGen UID:
452620
•Concept ID:
C0574785
•
Sign or Symptom
Synonyms: Lower Urinary Tract Symptom; Lower Urinary Tract Symptoms
SNOMED CT: Lower urinary tract symptoms (307541003); LUTS - lower urinary tract symptoms (307541003)

Definition

Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination. [from NCI]

Professional guidelines

PubMed

Long-term safety of ketamine and esketamine in treatment of depression.
Nikayin S, Murphy E, Krystal JH, Wilkinson ST
Expert Opin Drug Saf 2022 Jun;21(6):777-787. Epub 2022 Apr 19 doi: 10.1080/14740338.2022.2066651. PMID: 35416105
Management of urinary incontinence in postmenopausal women: An EMAS clinical guide.
Russo E, Caretto M, Giannini A, Bitzer J, Cano A, Ceausu I, Chedraui P, Durmusoglu F, Erkkola R, Goulis DG, Kiesel L, Lambrinoudaki I, Hirschberg AL, Lopes P, Pines A, Rees M, van Trotsenburg M, Simoncini T
Maturitas 2021 Jan;143:223-230. Epub 2020 Sep 30 doi: 10.1016/j.maturitas.2020.09.005. PMID: 33008675
Diagnosis and treatment of urinary tract infections across age groups.
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent clinical studies

Etiology

Benign Prostatic Hyperplasia: Rapid Evidence Review.
Arnold MJ, Gaillardetz A, Ohiokpehai J
Am Fam Physician 2023 Jun;107(6):613-622. PMID: 37327163
Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms: What Is the Role and Significance of Inflammation?
Lloyd GL, Marks JM, Ricke WA
Curr Urol Rep 2019 Aug 3;20(9):54. doi: 10.1007/s11934-019-0917-1. PMID: 31377881Free PMC Article
How does lower urinary tract dysfunction (LUTD) affect sexual function in men and women? ICI-RS 2015-Part 2.
Apostolidis A, Rantell A, Anding R, Kirschner-Hermanns R, Cardozo L
Neurourol Urodyn 2017 Apr;36(4):869-875. doi: 10.1002/nau.23088. PMID: 28444704
Voiding dysfunction in older men.
Chung A, Noguchi N, Chan L, Tse V
Curr Opin Urol 2016 Mar;26(2):177-83. doi: 10.1097/MOU.0000000000000265. PMID: 26765045
Do lower urinary tract symptoms predict cardiovascular diseases in older men? A systematic review and meta-analysis.
Bouwman II, Voskamp MJ, Kollen BJ, Nijman RJ, van der Heide WK, Blanker MH
World J Urol 2015 Dec;33(12):1911-20. Epub 2015 May 14 doi: 10.1007/s00345-015-1560-1. PMID: 25971203Free PMC Article

Diagnosis

Metabolic syndrome and male lower urinary tract symptoms.
Ineichen GB, Burkhard FC
Panminerva Med 2022 Sep;64(3):329-336. Epub 2021 Dec 3 doi: 10.23736/S0031-0808.21.04496-7. PMID: 34859639
Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA GUIDELINE PART I-Initial Work-up and Medical Management.
Lerner LB, McVary KT, Barry MJ, Bixler BR, Dahm P, Das AK, Gandhi MC, Kaplan SA, Kohler TS, Martin L, Parsons JK, Roehrborn CG, Stoffel JT, Welliver C, Wilt TJ
J Urol 2021 Oct;206(4):806-817. Epub 2021 Aug 13 doi: 10.1097/JU.0000000000002183. PMID: 34384237
Introduction.
Bhatia S
Tech Vasc Interv Radiol 2020 Sep;23(3):100686. Epub 2020 Oct 5 doi: 10.1016/j.tvir.2020.100686. PMID: 33308531
Benign Prostatic Hyperplasia.
Langan RC
Prim Care 2019 Jun;46(2):223-232. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.003. PMID: 31030823
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

Therapy

Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta-analysis.
He W, Zhang Y, Huang G, Tian Y, Sun Q, Liu X
Low Urin Tract Symptoms 2023 May;15(3):80-88. Epub 2023 Mar 2 doi: 10.1111/luts.12475. PMID: 36863312
Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials.
Bhanu C, Nimmons D, Petersen I, Orlu M, Davis D, Hussain H, Magammanage S, Walters K
PLoS Med 2021 Nov;18(11):e1003821. Epub 2021 Nov 9 doi: 10.1371/journal.pmed.1003821. PMID: 34752479Free PMC Article
Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.
Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.
Franco JV, Turk T, Jung JH, Xiao YT, Iakhno S, Garrote V, Vietto V
Cochrane Database Syst Rev 2018 May 12;5(5):CD012551. doi: 10.1002/14651858.CD012551.pub3. PMID: 29757454Free PMC Article
A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update.
Cornu JN, Ahyai S, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S
Eur Urol 2015 Jun;67(6):1066-1096. Epub 2014 Jun 25 doi: 10.1016/j.eururo.2014.06.017. PMID: 24972732

Prognosis

Prostate Cancer in Primary Care.
Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885Free PMC Article
The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates.
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338
Erectile dysfunction and lower urinary tract symptoms secondary to BPH.
McVary KT
Eur Urol 2005 Jun;47(6):838-45. Epub 2005 Feb 22 doi: 10.1016/j.eururo.2005.02.001. PMID: 15925081
Chronic prostatitis.
Batstone GR, Doble A
Curr Opin Urol 2003 Jan;13(1):23-9. doi: 10.1097/00042307-200301000-00005. PMID: 12490812

Clinical prediction guides

Hounsfield units: A promising non-invasive tool for diagnosing benign prostatic hyperplasia.
Yilmaz O, Hayit H, Yesildal C, Yenigurbuz S, Yilmaz F, Emre Kizilkan Y
Actas Urol Esp (Engl Ed) 2022 Sep;46(7):407-412. Epub 2022 Jun 28 doi: 10.1016/j.acuroe.2021.11.006. PMID: 35778339
Lower Urinary Tract Symptoms are Common After Artificial Urinary Sphincter Implantation.
Son HS, Kim JH
Urology 2022 Jul;165:343-350. Epub 2022 Jan 31 doi: 10.1016/j.urology.2022.01.031. PMID: 35108593
Urinary Function after Surgery for Deep Endometriosis: A Prospective Study.
Dior UP, Reddington C, Cheng C, Levin G, Healey M
J Minim Invasive Gynecol 2022 Feb;29(2):308-316.e2. Epub 2021 Aug 29 doi: 10.1016/j.jmig.2021.08.024. PMID: 34469822
Efficacy and safety of prostate artery embolization on lower urinary tract symptoms related to benign prostatic hyperplasia: a systematic review and meta-analysis.
Wang XY, Zong HT, Zhang Y
Clin Interv Aging 2016;11:1609-1622. Epub 2016 Nov 11 doi: 10.2147/CIA.S119241. PMID: 27956827Free PMC Article
Pelvic floor spasm as a cause of voiding dysfunction.
Kuo TL, Ng LG, Chapple CR
Curr Opin Urol 2015 Jul;25(4):311-6. doi: 10.1097/MOU.0000000000000174. PMID: 26049874

Recent systematic reviews

Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta-analysis.
He W, Zhang Y, Huang G, Tian Y, Sun Q, Liu X
Low Urin Tract Symptoms 2023 May;15(3):80-88. Epub 2023 Mar 2 doi: 10.1111/luts.12475. PMID: 36863312
Rezūm water vapor therapy for the treatment of patients with urinary retention and permanent catheter dependence secondary to benign prostate hyperplasia: a systematic review of the literature.
Spinos T, Katafigiotis I, Leotsakos I, Grivas N, Zabaftis C, Ermidis D, Sfoungaristos S, Karavitakis M
World J Urol 2023 Feb;41(2):413-420. Epub 2022 Dec 19 doi: 10.1007/s00345-022-04258-y. PMID: 36534152
European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence.
Nambiar AK, Arlandis S, Bø K, Cobussen-Boekhorst H, Costantini E, de Heide M, Farag F, Groen J, Karavitakis M, Lapitan MC, Manso M, Arteaga SM, Riogh ANA, O'Connor E, Omar MI, Peyronnet B, Phé V, Sakalis VI, Sihra N, Tzelves L, van Poelgeest-Pomfret ML, van den Bos TWL, van der Vaart H, Harding CK
Eur Urol 2022 Jul;82(1):49-59. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.045. PMID: 35216856
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338
A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update.
Cornu JN, Ahyai S, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S
Eur Urol 2015 Jun;67(6):1066-1096. Epub 2014 Jun 25 doi: 10.1016/j.eururo.2014.06.017. PMID: 24972732

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