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Lower urinary tract symptoms

MedGen UID:
452620
•Concept ID:
C0574785
•
Sign or Symptom
Synonyms: Lower Urinary Tract Symptom; Lower Urinary Tract Symptoms
SNOMED CT: Lower urinary tract symptoms (307541003); LUTS - lower urinary tract symptoms (307541003)

Definition

Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination. [from NCI]

Professional guidelines

PubMed

Pelvic-floor function, dysfunction, and treatment.
Quaghebeur J, Petros P, Wyndaele JJ, De Wachter S
Eur J Obstet Gynecol Reprod Biol 2021 Oct;265:143-149. Epub 2021 Aug 28 doi: 10.1016/j.ejogrb.2021.08.026. PMID: 34492609
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA
J Clin Endocrinol Metab 2018 May 1;103(5):1715-1744. doi: 10.1210/jc.2018-00229. PMID: 29562364
Diagnosis and treatment of urinary tract infections across age groups.
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent clinical studies

Etiology

Bowel function, urinary tract function, and health-related quality of life in males with anorectal malformations.
Gertler J, Granström AL, Oddsberg J, Gunnarsdóttir A, Svenningsson A, Wester T, Örtqvist L
Pediatr Surg Int 2024 Jun 27;40(1):164. doi: 10.1007/s00383-024-05746-5. PMID: 38935149Free PMC Article
Effects of Sleeve Gastrectomy on Pelvic Floor Disorders in Female Patients with Severe Obesity: a Prospective Study.
Güneş Y, Fersahoğlu MM, Bulut NE, Çakmak A, Ergin A, Teke E, Karataş TC, Şahin A, Sancak S
Obes Surg 2023 Oct;33(10):3069-3076. Epub 2023 Jul 10 doi: 10.1007/s11695-023-06725-w. PMID: 37428362
Urodynamic Curve Patterns may Predict Female Bladder Outlet Obstruction and Detrusor Underactivity.
Çetinel B, Önal B, Selçuk B, Can G, Aferin U, Yıldırım Ö
Urology 2022 Jul;165:150-156. Epub 2022 Apr 10 doi: 10.1016/j.urology.2022.03.027. PMID: 35413377
Effects of different types of hysterectomies on postoperative urodynamics and lower urinary tract symptoms.
Shin JH, Gwak CH, Park MU, Choo MS
Investig Clin Urol 2022 Mar;63(2):207-213. doi: 10.4111/icu.20210393. PMID: 35244995Free PMC Article
A comparison of flow rate curve shape and video-urodynamic findings in women with lower urinary tract symptoms: can flow rate curve shape predict female bladder outflow obstruction or detrusor underactivity?
Kocadag H, Toia B, Axell R, Yasmin H, Pakzad MH, Hamid R, Greenwell TJ, Ockrim JL
World J Urol 2021 May;39(5):1591-1595. Epub 2020 Jul 11 doi: 10.1007/s00345-020-03343-4. PMID: 32653952

Diagnosis

Comparative assessment of attitudes and expectations: Iranian patients versus urologists in the management of benign prostatic hyperplasia.
Hosseini J, Alinejad Khorram A, Abedi AR, Hosseini MA, Fayaz M
BMC Urol 2024 Oct 8;24(1):219. doi: 10.1186/s12894-024-01612-7. PMID: 39379872Free PMC Article
(A)voiding misdiagnosis: prediction of detrusor underactivity vs. bladder outlet obstruction using pre-urodynamic nomogram in male patients with LUTS.
Garbas K, Zapała Ł, Ślusarczyk A, Piecha T, Gwara P, Żuk-Łapan A, Piekarczyk H, Zapała P, Radziszewski P
Int Urol Nephrol 2024 Nov;56(11):3485-3494. Epub 2024 May 31 doi: 10.1007/s11255-024-04093-7. PMID: 38819576Free PMC Article
Giant stone in a urinary bladder diverticulum in a 69-year-old male: a case report.
Syarif S, Azis A, Patimura MIF, Putra MZDA, Nusraya A, Natsir AS
Pan Afr Med J 2023;45:181. Epub 2023 Aug 25 doi: 10.11604/pamj.2023.45.181.38723. PMID: 38020350Free PMC Article
Urodynamic Curve Patterns may Predict Female Bladder Outlet Obstruction and Detrusor Underactivity.
Çetinel B, Önal B, Selçuk B, Can G, Aferin U, Yıldırım Ö
Urology 2022 Jul;165:150-156. Epub 2022 Apr 10 doi: 10.1016/j.urology.2022.03.027. PMID: 35413377
A comparison of flow rate curve shape and video-urodynamic findings in women with lower urinary tract symptoms: can flow rate curve shape predict female bladder outflow obstruction or detrusor underactivity?
Kocadag H, Toia B, Axell R, Yasmin H, Pakzad MH, Hamid R, Greenwell TJ, Ockrim JL
World J Urol 2021 May;39(5):1591-1595. Epub 2020 Jul 11 doi: 10.1007/s00345-020-03343-4. PMID: 32653952

Therapy

The PINNACLE Study: A Double-blind, Randomized, Sham-controlled Study Evaluating the Optilume BPH Catheter System for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.
Kaplan SA, Moss J, Freedman S, Coutinho K, Wu N, Efros M, Elterman D, D'Anna R, Padron O, Robertson KJ, Lawindy S, Mistry S, Shore N, Spier J, Kaminetsky J, Mazzarella B, Cahn D, Jalkut M, Te A
J Urol 2023 Sep;210(3):500-509. Epub 2023 Aug 9 doi: 10.1097/JU.0000000000003568. PMID: 37555604
Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.
Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.
Franco JV, Turk T, Jung JH, Xiao YT, Iakhno S, Garrote V, Vietto V
Cochrane Database Syst Rev 2018 May 12;5(5):CD012551. doi: 10.1002/14651858.CD012551.pub3. PMID: 29757454Free PMC Article
WATER: A Double-Blind, Randomized, Controlled Trial of Aquablation(®) vs Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia.
Gilling P, Barber N, Bidair M, Anderson P, Sutton M, Aho T, Kramolowsky E, Thomas A, Cowan B, Kaufman RP Jr, Trainer A, Arther A, Badlani G, Plante M, Desai M, Doumanian L, Te AE, DeGuenther M, Roehrborn C
J Urol 2018 May;199(5):1252-1261. Epub 2018 Jan 31 doi: 10.1016/j.juro.2017.12.065. PMID: 29360529
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM; Task Force, Endocrine Society
J Clin Endocrinol Metab 2010 Jun;95(6):2536-59. doi: 10.1210/jc.2009-2354. PMID: 20525905

Prognosis

Bladder Bowel Dysfunction.
Aguiar LM, Franco I
Urol Clin North Am 2018 Nov;45(4):633-640. Epub 2018 Sep 7 doi: 10.1016/j.ucl.2018.06.010. PMID: 30316317
Prostate Cancer in Primary Care.
Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885Free PMC Article
Frailty and Lower Urinary Tract Symptoms.
Suskind AM
Curr Urol Rep 2017 Sep;18(9):67. doi: 10.1007/s11934-017-0720-9. PMID: 28718161Free PMC Article
The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates.
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

Clinical prediction guides

The Reduction of Male Lower Urinary Tract Symptoms Is Associated With a Decreased Risk of Death.
Welk B, McClure JA
J Urol 2023 Oct;210(4):670-677. Epub 2023 Sep 8 doi: 10.1097/JU.0000000000003602. PMID: 37681541
The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer's Disease.
Chang CW, Juan YS, Yang YH, Lee HY
Am J Alzheimers Dis Other Demen 2021 Jan-Dec;36:1533317521992657. doi: 10.1177/1533317521992657. PMID: 33635087Free PMC Article
Lower urinary tract symptoms that predict microscopic pyuria.
Khasriya R, Barcella W, De Iorio M, Swamy S, Gill K, Kupelian A, Malone-Lee J
Int Urogynecol J 2018 Jul;29(7):1019-1028. Epub 2017 Oct 2 doi: 10.1007/s00192-017-3472-7. PMID: 28971220Free PMC Article
Urinary tract infections in multiple sclerosis.
Phé V, Pakzad M, Curtis C, Porter B, Haslam C, Chataway J, Panicker JN
Mult Scler 2016 Jun;22(7):855-61. Epub 2016 Feb 18 doi: 10.1177/1352458516633903. PMID: 26892318
Benign prostatic hyperplasia and lower urinary tract symptoms: research priorities.
De Nunzio C, Ahyai S, Autorino R, Bachmann A, Bialek W, Briganti A, Reich O, Sosnowski R, Thiruchelvam N, Novara G; European Association of Urology Young Academic Urologists BPH Group
Eur Urol 2011 Dec;60(6):1205-6. Epub 2011 Sep 7 doi: 10.1016/j.eururo.2011.08.055. PMID: 21930341

Recent systematic reviews

"Nocturia and obstructive sleep apnea syndrome: A systematic review".
Di Bello F, Napolitano L, Abate M, Collà Ruvolo C, Morra S, Califano G, Capece M, Creta M, Scandurra C, Muzii B, Di Nola C, Bochicchio V, Nocini R, Abbate V, Maldonato NM, Dell'Aversana Orabona G, Longo N, Cantone E
Sleep Med Rev 2023 Jun;69:101787. Epub 2023 Apr 29 doi: 10.1016/j.smrv.2023.101787. PMID: 37167825
European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence.
Nambiar AK, Arlandis S, Bø K, Cobussen-Boekhorst H, Costantini E, de Heide M, Farag F, Groen J, Karavitakis M, Lapitan MC, Manso M, Arteaga SM, Riogh ANA, O'Connor E, Omar MI, Peyronnet B, Phé V, Sakalis VI, Sihra N, Tzelves L, van Poelgeest-Pomfret ML, van den Bos TWL, van der Vaart H, Harding CK
Eur Urol 2022 Jul;82(1):49-59. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.045. PMID: 35216856
Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network meta-analysis.
Franco JV, Jung JH, Imamura M, Borofsky M, Omar MI, Escobar Liquitay CM, Young S, Golzarian J, Veroniki AA, Garegnani L, Dahm P
Cochrane Database Syst Rev 2021 Jul 15;7(7):CD013656. doi: 10.1002/14651858.CD013656.pub2. PMID: 34693990Free PMC Article
Pregnancy- and obstetric-related risk factors for urinary incontinence, fecal incontinence, or pelvic organ prolapse later in life: A systematic review and meta-analysis.
Hage-Fransen MAH, Wiezer M, Otto A, Wieffer-Platvoet MS, Slotman MH, Nijhuis-van der Sanden MWG, Pool-Goudzwaard AL
Acta Obstet Gynecol Scand 2021 Mar;100(3):373-382. Epub 2020 Nov 2 doi: 10.1111/aogs.14027. PMID: 33064839
Benign prostate hyperplasia and nutrition.
Das K, Buchholz N
Clin Nutr ESPEN 2019 Oct;33:5-11. Epub 2019 Aug 12 doi: 10.1016/j.clnesp.2019.07.015. PMID: 31451276

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